CTLA4

Summary Top Help

Gene Description:

cytotoxic T-lymphocyte-associated protein 4

Synonyms:

ICOS, CELIAC3, CTLA4, Ctla-4, sCTLA4, Cd152, IDDM12, GRD4, CTLA-4, GSE, Ly-56, CD, CD152, Ctla4

Orthologs:

Human CTLA4 (protein-coding), Mouse Ctla4 (protein-coding), Rat Ctla4 (protein-coding)

Sources

Study Associations from T1DBase Top Help

Genome Wide Association Studies: 1 Available

Study	Region	Marker	P-value	Gene(s) of Interest	Publication	Notes	Details
Whole Genome Association Study:T1D:Barrett JC:Nat Genet:2009:19430480	2q33.2	rs3087243	1.2e-15	CTLA4	19430480

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Human: 1 Mouse: 2 Rat: 1

Associated Regions: 1 Available

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
2q33.2	Human	chr2:204672809..204820058	0.15	2	rs3087243

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd5.1	Mouse	chr1:60883084..62840206	1.96	4	3 no lod score

Other Regions: 2 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 2q33.2 Orthologous Region	Mouse	chr1:60913616..61051726	0.14	2
Human 2q33.2 Orthologous Region	Rat	chr9:59449044..59556611	0.11	1

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr2:204732504..204743422 (10.92 kb) View in Genome Browser

(Mouse) NCBIM37 - chr1:60943844..60972676 (28.83 kb) View in Genome Browser

(Rat) RGSC3.4 - chr9:59495773..59501300 (5.53 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CTLA4:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
			no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CTLA4:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 4

Biocarta: 1

Reactome: 2

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 15

Publications from PubMed Top Help

Type 1 Diabetes Publications: 137

Low CTLA-4 expression in CD4+ helper T-cells in patients with fulminant type 1 diabetes.
Haseda F, Imagawa A, Murase-Mishiba Y, Sano H, Hirano-Kuwata S, Ueda H, Terasaki J, Hanafusa T
Immunol Lett. 2011
PubMed ID: 21620894
A cluster of coregulated genes determines TGF-{beta}-induced regulatory T-cell (Treg) dysfunction in NOD mice.
D'Alise AM, Ergun A, Hill JA, Mathis D, Benoist C
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21543717
The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function.
Gerold KD, Zheng P, Rainbow DB, Zernecke A, Wicker LS, Kissler S
Diabetes. 2011
PubMed ID: 21602513
Association of HLA class II alleles and CTLA-4 polymorphism with type 1 diabetes.
Ei Wafai RJ, Chmaisse HN, Makki RF, Fakhoury H
Saudi J Kidney Dis Transpl. 2011
PubMed ID: 21422625
A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.
Budarf ML, Goyette P, Boucher G, Lian J, Graham RR, Claudio JO, Hudson T, Gladman D, Clarke AE, Pope JE, Peschken C, Smith CD, Hanly J, Rich E, Boire G, Barr SG, Zummer M, GenES Investigators, Fortin PR, Wither J, Rioux JD
Genes Immun. 2010
PubMed ID: 20962850
Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity.
Moriguchi M, Noso S, Kawabata Y, Yamauchi T, Harada T, Komaki K, Babaya N, Hiromine Y, Ito H, Yamagata S, Murata K, Higashimoto T, Park C, Yamamoto A, Ohno Y, Ikegami H
Metabolism. 2010
PubMed ID: 20825955
Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years.
Andersen MK, Lundgren V, Turunen JA, Forsblom C, Isomaa B, Groop PH, Groop L, Tuomi T
Diabetes Care. 2010
PubMed ID: 20805278
CTLA-4 -318C/T, +49A/G, and CT60A/G Polymorphisms and Susceptibility to Autoimmune Type 1 Diabetes in Tunisians.
Benmansour J, Stayoussef M, Al-Jenaidi FA, Rajab MH, Rayana CB, Said HB, Mahjoub T, Almawi WY
Clin Vaccine Immunol. 2010
PubMed ID: 20610662
Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1 diabetes.
Karumuthil-Melethil S, Perez N, Li R, Prabhakar BS, Holterman MJ, Vasu C
J Immunol. 2010
PubMed ID: 20483724
In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium.
Qu HQ, Bradfield JP, Li Q, Kim C, Frackelton E, Grant SF, Hakonarson H, Polychronakos C
Hum Mol Genet. 2010
PubMed ID: 20378605
Changes in frequency of IDDM-associated HLA DQB, CTLA4 and INS alleles.
Witas HW, Jędrychowska-Dańska K, Zawicki P
Int J Immunogenet. 2010
PubMed ID: 20345871
Remapping the type I diabetes association of the CTLA4 locus.
Qu HQ, Bradfield JP, Grant SF, Hakonarson H, Polychronakos C, Type I Diabetes Genetics Consortium
Genes Immun. 2009
PubMed ID: 19956097
Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms and HLA class II alleles with the development of type 1 diabetes in Korean children and adolescents.
Jung MH, Yu J, Shin CH, Suh BK, Yang SW, Lee BC
J Korean Med Sci. 2009
PubMed ID: 19949652
An inverse association between history of childhood eczema and subsequent risk of type 1 diabetes that is not likely to be explained by HLA-DQ, PTPN22, or CTLA4 polymorphisms.
Stene LC, Rønningen KS, Bjørnvold M, Undlien DE, Joner G
Pediatr Diabetes. 2009
PubMed ID: 19895409
CTLA-4 promoter polymorphisms are associated with latent autoimmune diabetes in adults.
Douroudis K, Prans E, Uibo R
Hum Immunol. 2009
PubMed ID: 19735686
Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with type 1 diabetes in Croatians.
Korolija M, Renar IP, Hadžija M, Medvidović EP, Pavković P, Jokić M, Hadžija MP
Diabetes Res Clin Pract. 2009
PubMed ID: 19815302
Genetic Evidence That the Differential Expression of the Ligand-Independent Isoform of CTLA-4 Is the Molecular Basis of the Idd5.1 Type 1 Diabetes Region in Nonobese Diabetic Mice.
Araki M, Chung D, Liu S, Rainbow DB, Chamberlain G, Garner V, Hunter KM, Vijayakrishnan L, Peterson LB, Oukka M, Sharpe AH, Sobel R, Kuchroo VK, Wicker LS
J Immunol. 2009
PubMed ID: 19783679
Associations of the CTLA-4 polymorphisms with type 1 diabetes in a Chilean population: case-parent design.
Angel B, Balic I, Santos JL, Codner E, Carrasco E, Pérez-Bravo F
Diabetes Res Clin Pract. 2009
PubMed ID: 19592124
Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes.
Lempainen J, Vaarala O, Mäkelä M, Veijola R, Simell O, Knip M, Hermann R, Ilonen J
J Autoimmun. 2009
PubMed ID: 19473815
Polymorphisms in the CD28/CTLA4/ICOS genes: role in malignant melanoma susceptibility and prognosis?
Bouwhuis MG, Gast A, Figl A, Eggermont AM, Hemminki K, Schadendorf D, Kumar R
Cancer Immunol Immunother. 2009
PubMed ID: 19672595
CTLA-4 CT60 polymorphism in thyroid and polyglandular autoimmunity.
Dultz G, Matheis N, Dittmar M, Bender K, Kahaly GJ
Horm Metab Res. 2009
PubMed ID: 19530270
The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 diabetes mellitus in the Portuguese population.
Lemos MC, Coutinho E, Gomes L, Bastos M, Fagulha A, Barros L, Carrilho F, Geraldes E, Regateiro FJ, Carvalheiro M
Int J Immunogenet. 2009
PubMed ID: 19490216
[Association of CTLA-4 + 49A/G and CT60 gene polymorphism with type 1 diabetes and thyroid autoimmunity]
Jin P, Xiang B, Lin J, Huang G, Zhou WD, Zheng C, Chao C, Zhou ZG
Zhonghua Yi Xue Za Zhi. 2009
PubMed ID: 19595177
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, The Type 1 Diabetes Genetics Consortium
Nat Genet. 2009
PubMed ID: 19430480
Cytotoxic T-lymphocyte antigen 4 gene polymorphisms are associated with latent autoimmune diabetes in adults.
Douroudis K, Prans E, Kisand K, Nemvalts V, Uibo R
Clin Chim Acta. 2009
PubMed ID: 19332045
Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates.
Douroudis K, Laine AP, Heinonen M, Hermann R, Lipponen K, Veijola R, Simell O, Knip M, Uibo R, Ilonen J, Kisand K
Hum Immunol. 2009
PubMed ID: 19376178
Type 1 diabetes susceptibility determined by HLA alleles and CTLA-4 and insulin genes polymorphisms in Brazilians.
Ferreira AC, Gomes KB, Sampaio IB, de Oliveira VC, Pardini VC, Godard AL
Arq Bras Endocrinol Metabol. 2009
PubMed ID: 19578600
[+49 A/G genetic polymorphism of cytotoxic T lymphocyte associated antigen 4 (CTLA-4) in type 7 diabetes: association with autoantibodies and cytokines]
Pérez B F, Codner D E, Angel B B, Balic N I, Carrasco P E
Rev Med Chil. 2009
PubMed ID: 19621172
Interactions between programmed death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) gene polymorphisms in type 1 diabetes.
Momin S, Flores S, Angel B B, Codner D E, Carrasco P E, Perez-Bravo F
Diabetes Res Clin Pract. 2009
PubMed ID: 19147248
Do non-HLA Genes Influence Development of Persistent Islet Autoimmunity and Type 1 Diabetes in Children with High-Risk HLA-DR,DQ Genotypes?
Steck AK, Zhang W, Bugawan TL, Barriga KJ, Blair A, Erlich HA, Eisenbarth GS, Norris JM, Rewers MJ
Diabetes. 2009
PubMed ID: 19188433
MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth.
Badenhoop K, Kahles H, Seidl C, Kordonouri O, Lopez ER, Walter M, Rosinger S, Ziegler A, Böhm BO, Diabetes Genetics Consortium
Diabetes Obes Metab. 2009
PubMed ID: 19143820
Association of CTLA-4 polymorphisms and clinical-immunologic characteristics at onset of type 1 diabetes mellitus in children.
Balic I, Angel B, Codner E, Carrasco E, Pérez-Bravo F
Hum Immunol. 2009
PubMed ID: 19136037
AUTOIMMUNE THYROIDITIS AND DIABETES: DISSECTING THE JOINT GENETIC SUSCEPTIBILITY IN A LARGE COHORT OF MULTIPLEX FAMILIES.
Villano MJ, Huber AK, Greenberg DA, Golden BK, Concepcion E, Tomer Y
J Clin Endocrinol Metab. 2009
PubMed ID: 19141582
Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.
Carr EJ, Niederer HA, Williams J, Harper L, Watts RA, Lyons PA, Smith KG
BMC Med Genet. 2009
PubMed ID: 19951419
Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes.
Luczyński W, Wawrusiewicz-Kurylonek N, Stasiak-Barmuta A, Urban R, Iłendo E, Urban M, Hryszko M, Kretowski A, Górska M
Acta Biochim Pol. 2009
PubMed ID: 19547759
Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity.
Schmidt EM, Wang CJ, Ryan GA, Clough LE, Qureshi OS, Goodall M, Abbas AK, Sharpe AH, Sansom DM, Walker LS
J Immunol. 2009
PubMed ID: 19109158
Shared and distinct genetic variants in type 1 diabetes and celiac disease.
Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA
N Engl J Med. 2008
PubMed ID: 19073967
CD40 on NOD CD4 T cells contributes to their activation and pathogenicity.
Baker RL, Wagner DH, Haskins K
J Autoimmun. 2008
PubMed ID: 18951762
Association of Type 1 Diabetes with Two Loci on 12q13 and 16p13 and the Influence Coexisting Thyroid Autoimmunity in Japanese.
Awata T, Kawasaki E, Tanaka S, Ikegami H, Maruyama T, Shimada A, Nakanishi K, Kobayashi T, Iizuka H, Uga M, Kawabata Y, Kanazawa Y, Kurihara S, Osaki M, Katayama S, on behalf of the Japanese Study Group on Type 1 Diabetes Genetics
J Clin Endocrinol Metab. 2008
PubMed ID: 18940880
Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children.
Walldén J, Ilonen J, Roivainen M, Ludvigsson J, Vaarala O, ABIS Study Group
Scand J Immunol. 2008
PubMed ID: 18782261
Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the DPT1 trial.
Butty V, Campbell C, Mathis D, Benoist C, the Diabetes Prevention Trial-Type 1 Study Group
Diabetes. 2008
PubMed ID: 18556337
CTLA-4 gene polymorphisms predispose to autoimmune endocrinopathies but not to celiac disease.
Dallos T, Avbelj M, Barák L, Zapletalová J, Pribilincová Z, Krajcírová M, Kostálová L, Battelino T, Kovács L
Neuro Endocrinol Lett. 2008
PubMed ID: 18580850
Differences in the Contribution of CTLA4 Gene to Susceptibility to Fulminant and Type 1A Diabetes in Japanese Patients.
Kawasaki E, Imagawa A, Makino H, Uga M, Abiru N, Hanafusa T, Uchigata Y, Eguchi K
Diabetes Care. 2008
PubMed ID: 18443194
Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes.
Bjørnvold M, Undlien DE, Joner G, Dahl-Jørgensen K, Njølstad PR, Akselsen HE, Gervin K, Rønningen KS, Stene LC
Diabetologia. 2008
PubMed ID: 18292987
Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes.
Hunter K, Rainbow D, Plagnol V, Todd JA, Peterson LB, Wicker LS
J Immunol. 2007
PubMed ID: 18056379
Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study.
Eising S, Svensson J, Skogstrand K, Nilsson A, Lynch K, Andersen PS, Lernmark A, Hougaard DM, Pociot F, Nørgaard-Pedersen B, Nerup J
Paediatr Perinat Epidemiol. 2007
PubMed ID: 17937736
The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children.
Jonson CO, Lernmark A, Ludvigsson J, Rutledge EA, Hinkkanen A, Faresjö M
Pediatr Diabetes. 2007
PubMed ID: 17659059
A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.
Howson JM, Dunger DB, Nutland S, Stevens H, Wicker LS, Todd JA
Diabetologia. 2007
PubMed ID: 17334650
Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes.
Payne F, Cooper JD, Walker NM, Lam AC, Smink LJ, Nutland S, Stevens HE, Hutchings J, Todd JA
J Leukoc Biol. 2007
PubMed ID: 17209142
Insulin gene VNTR, CTLA-4 +49A/G and HLA-DQB1 alleles distinguish latent autoimmune diabetes in adults from type 1 diabetes and from type 2 diabetes group.
Haller K, Kisand K, Pisarev H, Salur L, Laisk T, Nemvalts V, Uibo R
Tissue Antigens. 2007
PubMed ID: 17257313
No evidence of association of CTLA-4 -318 C/T, 159 C/T, 3' STR and SUMO4 163 AG polymorphism with autoimmune diabetes.
Caputo M, Cerrone GE, Mazza C, Cédola N, Targovnik HM, Gustavo DF
Immunol Invest. 2007
PubMed ID: 17558709
CT60 genotype does not affect CTLA-4 isoform expression despite association to T1D and AITD in northern Sweden.
Mayans S, Lackovic K, Nyholm C, Lindgren P, Ruikka K, Eliasson M, Cilio CM, Holmberg D
BMC Med Genet. 2007
PubMed ID: 17280620
Modeling CTLA4-linked autoimmunity with RNA interference in mice.
Chen Z, Stockton J, Mathis D, Benoist C
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17060611
Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the Japanese.
Kanazawa Y, Motohashi Y, Yamada S, Oikawa Y, Shigihara T, Okubo Y, Maruyama T, Shimada A
Ann N Y Acad Sci. 2006
PubMed ID: 17130562
Genetics of type 1 diabetes: similarities and differences between Asian and Caucasian populations.
Ikegami H, Fujisawa T, Kawabata Y, Noso S, Ogihara T
Ann N Y Acad Sci. 2006
PubMed ID: 17130532
Functional evaluation of the autoimmunity-associated CTLA4 gene: the effect of the (AT) repeat in the 3'untranslated region (UTR).
Anjos SM, Polychronakos C
J Autoimmun. 2006
PubMed ID: 16891094
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA
J Clin Invest. 2006
PubMed ID: 16886063
The association of CTLA-4 and HLA class II autoimmune risk genotype with regulatory T cell marker expression in 5-year-old children.
Jonson CO, Hedman M, Karlsson Faresjö M, Casas R, Ilonen J, Ludvigsson J, Vaarala O, ABIS Study Group
Clin Exp Immunol. 2006
PubMed ID: 16792673
Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes.
Maier LM, Howson JM, Walker N, Spickett GP, Jones RW, Ring SM, McArdle WL, Lowe CE, Bailey R, Payne F, Todd JA, Strachan DP
J Allergy Clin Immunol. 2006
PubMed ID: 16750991
Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.
Hermann R, Lipponen K, Kiviniemi M, Kakko T, Veijola R, Simell O, Knip M, Ilonen J
Diabetologia. 2006
PubMed ID: 16614815
Promoter region -318 C/ T and -1661 A/G CTLA-4 single nucleotide polymorphisms and type 1 diabetes in North Indians.
Baniasadi V, Narain N, Goswami R, Das SN
Tissue Antigens. 2006
PubMed ID: 16671945
Genetic association of type 1 diabetes in an Azerbaijanian population: the HLA-DQ, -DRB1*04, the insulin gene, and CTLA4.
Ahmedov G, Ahmedova L, Sedlakova P, Cinek O
Pediatr Diabetes. 2006
PubMed ID: 16629714
Risk of celiac disease in children with type 1 diabetes is modified by positivity for HLA-DQB1*02-DQA1*05 and TNF -308A.
Sumnik Z, Cinek O, Bratanic N, Kordonouri O, Kulich M, Roszai B, Arato A, Lebl J, Soltesz G, Danne T, Battelino T, Schober E
Diabetes Care. 2006
PubMed ID: 16567828
The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan.
Ikegami H, Awata T, Kawasaki E, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Amemiya S, Kawabata Y, Kurihara S, Tanaka S, Kanazawa Y, Mochizuki M, Ogihara T
J Clin Endocrinol Metab. 2006
PubMed ID: 16352685
Antigen exposure during enhanced CTLA-4 expression promotes allograft tolerance in vivo.
Salvalaggio PR, Camirand G, Ariyan CE, Deng S, Rogozinski L, Basadonna GP, Rothstein DM
J Immunol. 2006
PubMed ID: 16455985
Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1.
Lundholm M, Motta V, Löfgren-Burström A, Duarte N, Bergman ML, Mayans S, Holmberg D
Diabetes. 2006
PubMed ID: 16443792
No evidence of a significant role for CTLA-4 in multiple sclerosis.
Roxburgh RH, Sawcer S, Maranian M, Seaman S, Hensiek A, Yeo T, Deans J, Compston A
J Neuroimmunol. 2006
PubMed ID: 16325273
Genetic interaction among three genomic regions creates distinct contributions to early- and late-onset type 1 diabetes mellitus.
Felner EI, Klitz W, Ham M, Lazaro AM, Stastny P, Dupont B, White PC
Pediatr Diabetes. 2005
PubMed ID: 16390390
Polymorphisms at +49A/G and CT60 sites in the 3' UTR of the CTLA-4 gene and APECED-related AIRE gene mutations analysis in sporadic idiopathic hypoparathyroidism.
Goswami R, Gupta N, Ray D, Rani R, Tomar N, Sarin R, Vupputuri MR
Int J Immunogenet. 2005
PubMed ID: 16313305
Haplotype tagging efficiency in worldwide populations in CTLA4 gene.
Ramírez-Soriano A, Lao O, Soldevila M, Calafell F, Bertranpetit J, Comas D
Genes Immun. 2005
PubMed ID: 16034471
Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes.
Purohit S, Podolsky R, Collins C, Zheng W, Schatz D, Muir A, Hopkins D, Huang YH, She JX
J Autoimmune Dis. 2005
PubMed ID: 16259622
CTLA4 is differentially associated with autoimmune diseases in the Dutch population.
Zhernakova A, Eerligh P, Barrera P, Wesoly JZ, Weseloy JZ, Huizinga TW, Roep BO, Wijmenga C, Koeleman BP
Hum Genet. 2005
PubMed ID: 16025348
The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity.
Hermann R, Laine AP, Veijola R, Vahlberg T, Simell S, Lähde J, Simell O, Knip M, Ilonen J
Diabetologia. 2005
PubMed ID: 16025255
Association of non-HLA genes with type 1 diabetes autoimmunity.
Steck AK, Bugawan TL, Valdes AM, Emery LM, Blair A, Norris JM, Redondo MJ, Babu SR, Erlich HA, Eisenbarth GS, Rewers MJ
Diabetes. 2005
PubMed ID: 16046318
Genetic analysis of families with autoimmune diabetes and thyroiditis: evidence for common and unique genes.
Golden B, Levin L, Ban Y, Concepcion E, Greenberg DA, Tomer Y
J Clin Endocrinol Metab. 2005
PubMed ID: 15928253
CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE Review and meta-analysis.
Kavvoura FK, Ioannidis JP
Am J Epidemiol. 2005
PubMed ID: 15961581
Cytotoxic T lymphocyte antigen 4 heterozygous codon 49 A/G dimorphism is associated to latent autoimmune diabetes in adults (LADA).
Caputo M, Cerrone GE, López AP, Villalba A, Krochik GA, Cédola FN, Targovnik HM, Frechtel GD
Autoimmunity. 2005
PubMed ID: 16206510
CTLA-4 +49 A/G polymorphism is associated with predisposition to type 1 diabetes in Iranians.
Mojtahedi Z, Omrani GR, Doroudchi M, Ghaderi A
Diabetes Res Clin Pract. 2005
PubMed ID: 15860238
CBLB variants in type 1 diabetes and their genetic interaction with CTLA4.
Bergholdt R, Taxvig C, Eising S, Nerup J, Pociot F
J Leukoc Biol. 2005
PubMed ID: 15629882
Detection and frequency estimation of rare variants in pools of genomic DNA from large populations using mutational spectrometry.
Li-Sucholeiki XC, Tomita-Mitchell A, Arnold K, Glassner BJ, Thompson T, Murthy JV, Berk L, Lange C, Leong-Morgenthaler PM, MacDougall D, Munro J, Cannon D, Mistry T, Miller A, Deka C, Karger B, Gillespie KM, Ekstrøm PO, Todd JA, Thilly WG
Mutat Res. 2005
PubMed ID: 15708585
IL-10 diminishes CTLA-4 expression on islet-resident T cells and sustains their activation rather than tolerance.
Gregg RK, Bell JJ, Lee HH, Jain R, Schoenleber SJ, Divekar R, Zaghouani H
J Immunol. 2005
PubMed ID: 15634884
Estimation of diabetes risk in Brazilian population by typing for polymorphisms in HLA-DR-DQ, INS and CTLA-4 genes.
Hauache OM, Reis AF, Oliveira CS, Vieira JG, Sjöroos M, Ilonen J
Dis Markers. 2005
PubMed ID: 16276008
Association of the cytotoxic T lymphocyte-associated antigen 4 gene with type 1 diabetes: evidence for independent effects of two polymorphisms on the same haplotype block.
Anjos SM, Tessier MC, Polychronakos C
J Clin Endocrinol Metab. 2004
PubMed ID: 15579786
Association between CTLA-4 +49 A/G polymorphism and type 1B diabetes in Japanese population.
Liang H, Yagi K, Asano A, Kobayashi J, Mabuchi H
Endocrine. 2004
PubMed ID: 15711022
Type 1 diabetes is insulin -2221 MspI and CTLA-4 +49 A/G polymorphism dependent.
Haller K, Kisand K, Nemvalts V, Laine AP, Ilonen J, Uibo R
Eur J Clin Invest. 2004
PubMed ID: 15305888
Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene.
Zalloua PA, Abchee A, Shbaklo H, Zreik TG, Terwedow H, Halaby G, Azar ST
Hum Immunol. 2004
PubMed ID: 15301861
Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease.
Blomhoff A, Lie BA, Myhre AG, Kemp EH, Weetman AP, Akselsen HE, Huseby ES, Undlien DE
J Clin Endocrinol Metab. 2004
PubMed ID: 15240634
Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.
Wicker LS, Chamberlain G, Hunter K, Rainbow D, Howlett S, Tiffen P, Clark J, Gonzalez-Munoz A, Cumiskey AM, Rosa RL, Howson JM, Smink LJ, Kingsnorth A, Lyons PA, Gregory S, Rogers J, Todd JA, Peterson LB
J Immunol. 2004
PubMed ID: 15210771
Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen.
Eggena MP, Walker LS, Nagabhushanam V, Barron L, Chodos A, Abbas AK
J Exp Med. 2004
PubMed ID: 15210748
Analysis of cytotoxic T lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism in patients with type 1 diabetes mellitus in a Turkish population.
Genc S, Genc K, Sercan O, Kizildag S, Gulay Z, Atay T, Dundar B, Sakizli M, Büyükgebiz A
J Pediatr Endocrinol Metab. 2004
PubMed ID: 15237707
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.
Vijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK
Immunity. 2004
PubMed ID: 15142525
The emerging role of the CTLA-4 gene in autoimmune endocrinopathies.
Vaidya B, Pearce S
Eur J Endocrinol. 2004
PubMed ID: 15132716
Haplotype analysis in simplex families and novel analytic approaches in a case-control cohort reveal no evidence of association of the CTLA-4 gene with rheumatoid arthritis.
Barton A, Jury F, Eyre S, Bowes J, Hinks A, Ward D, Worthington J
Arthritis Rheum. 2004
PubMed ID: 15022315
Association between IL-18 gene promoter polymorphisms and CTLA-4 gene 49A/G polymorphism in Japanese patients with type 1 diabetes.
Ide A, Kawasaki E, Abiru N, Sun F, Kobayashi M, Fukushima T, Takahashi R, Kuwahara H, Kita A, Oshima K, Uotani S, Yamasaki H, Yamaguchi Y, Eguchi K
J Autoimmun. 2004
PubMed ID: 14709415
Coeliac disease: investigation of proposed causal variants in the CTLA4 gene region.
King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ciclitira PJ
Eur J Immunogenet. 2003
PubMed ID: 14675397
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC
Nature. 2003
PubMed ID: 12724780
Association of the CTLA4 promoter region (-1661G allele) with type 1 diabetes in the South Moroccan population.
Bouqbis L, Izaabel H, Akhayat O, Pérez-Lezaun A, Calafell F, Bertranpetit J, Comas D
Genes Immun. 2003
PubMed ID: 12618861
Association of the CTLA-4 gene 49 A/G polymorphism with type 1 diabetes and autoimmune thyroid disease in Japanese children.
Mochizuki M, Amemiya S, Kobayashi K, Kobayashi K, Shimura Y, Ishihara T, Nakagomi Y, Onigata K, Tamai S, Kasuga A, Nanazawa S
Diabetes Care. 2003
PubMed ID: 12610047
CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen.
Walker LS, Ausubel LJ, Chodos A, Bekarian N, Abbas AK
J Immunol. 2002
PubMed ID: 12444125
CTLA-4-Ig regulates tryptophan catabolism in vivo.
Grohmann U, Orabona C, Fallarino F, Vacca C, Calcinaro F, Falorni A, Candeloro P, Belladonna ML, Bianchi R, Fioretti MC, Puccetti P
Nat Immunol. 2002
PubMed ID: 12368911
CTLA-4 gene A/G polymorphism associated with diabetes mellitus in Han Chinese.
Ma Y, Tang X, Chang W, Gao L, Li M, Yan W
Chin Med J (Engl). 2002
PubMed ID: 12515273
Association of CTLA-4 variation with type I diabetes in Filipinos.
Klitz W, Bugawan TL, Panelo A, Solfelix CM, Buzzetti R, Pozzilli P, Steiner L, Alejandrino M, Erlich HA
Immunogenetics. 2002
PubMed ID: 12185534
A recently described polymorphism in the CD28 gene on chromosome 2q33 is not associated with susceptibility to type 1 diabetes.
Wood JP, Pani MA, Bieda K, Meyer G, Usadel KH, Badenhoop K
Eur J Immunogenet. 2002
PubMed ID: 12121283
Locally expressed CTLA4-Ig in a pancreatic beta-cell line suppresses accelerated graft rejection response induced by donor-specific transfusion.
Kimura F, Gotoh M, Tanaka T, Luo Z, Miyazaki J, Uede T, Monden M, Miyasaka M
Diabetologia. 2002
PubMed ID: 12107727
CTLA-4 49 A/G dimorphism and type 1 diabetes susceptibility: a French case-control study and segregation analysis. Evidence of a maternal effect.
Fajardy I, Vambergue A, Stuckens C, Weill J, Danze PM, Fontaine P
Eur J Immunogenet. 2002
PubMed ID: 12047362
The CTLA4 +49 A/G dimorphism is not associated with type 1 diabetes in Czech children.
Cinek O, Drevínek P, Sumník Z, Bendlová B, Kolousková S, Snajderová M, Vavrinec J
Eur J Immunogenet. 2002
PubMed ID: 12047357
Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.
Graham J, Hagopian WA, Kockum I, Li LS, Sanjeevi CB, Lowe RM, Schaefer JB, Zarghami M, Day HL, Landin-Olsson M, Palmer JP, Janer-Villanueva M, Hood L, Sundkvist G, Lernmark A, Breslow N, Dahlquist G, Blohmé G, Diabetes Incidence in Sweden Study Group, Swedish Childhood Diabetes Study Group
Diabetes. 2002
PubMed ID: 11978629
CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults.
Cosentino A, Gambelunghe G, Tortoioli C, Falorni A
Ann N Y Acad Sci. 2002
PubMed ID: 12021137
An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies.
Vaidya B, Pearce SH, Charlton S, Marshall N, Rowan AD, Griffiths ID, Kendall-Taylor P, Cawston TE, Young-Min S
Rheumatology (Oxford). 2002
PubMed ID: 11886967
IDD3 and IDD5 alleles from nod mice mediate Sjögren's syndrome-like autoimmunity.
Cha S, Nagashima H, Peck AB, Humphreys-Beher MG
Adv Exp Med Biol. 2002
PubMed ID: 12614028
The study of CTLA-4 and vitamin D receptor polymorphisms in the Romanian type 1 diabetes population.
Guja C, Marshall S, Welsh K, Merriman M, Smith A, Todd JA, Ionescu-Tîrgoviste C
J Cell Mol Med. 2002
PubMed ID: 12003670
Markers for risk of type 1 diabetes in relatives of Alsacian patients with type 1 diabetes.
Ongagna JC, Sapin R, Pinget M, Belcourt A
Int J Exp Diabetes Res. 2002
PubMed ID: 11900275
Role of the B7-CD28/CTLA-4 pathway in autoimmune disease.
Chang TT, Kuchroo VK, Sharpe AH
Curr Dir Autoimmun. 2002
PubMed ID: 11826754
[Association between type 1 diabetes and polymorphism of the CTLA-4 gene in a Tunisian population]
Kamoun Abid H, Hmida S, Smaoui N, Kaabi H, Abid A, Chaabouni H, Boukef K, Nagati K
Pathol Biol (Paris). 2001
PubMed ID: 11776689
Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice.
Lamhamedi-Cherradi SE, Boulard O, Gonzalez C, Kassis N, Damotte D, Eloy L, Fluteau G, Lévi-Strauss M, Garchon HJ
Diabetes. 2001
PubMed ID: 11723074
CTLA4 gene polymorphism contributes to the mode of onset of diabetes with antiglutamic acid decarboxylase antibody in Japanese patients: genetic analysis of diabetic patients with antiglutamic acid decarboxylase antibody.
Abe T, Yamaguchi Y, Takino H, Fujita N, Yamauchi-Degawa M, Ozaki M, Yamakawa K, Sera Y, Sakamaki H, Uotani S, Kawasaki E, Awata T, Yamasaki H, Eguchi K
Diabet Med. 2001
PubMed ID: 11606170
Association of a novel point mutation (C159G) of the CTLA4 gene with type 1 diabetes in West Africans but not in Chinese.
Osei-Hyiaman D, Hou L, Zhiyin R, Zhiming Z, Yu H, Amankwah AA, Harada S
Diabetes. 2001
PubMed ID: 11522687
Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with type 1 diabetes in the Japanese population.
Ihara K, Ahmed S, Nakao F, Kinukawa N, Kuromaru R, Matsuura N, Iwata I, Nagafuchi S, Kohno H, Miyako K, Hara T
Immunogenetics. 2001
PubMed ID: 11685455
Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population.
McCormack RM, Maxwell AP, Carson D, Patterson CC, Bingham A, Savage DA
Genes Immun. 2001
PubMed ID: 11477480
The promoter region of the CTLA4 gene is associated with type 1 diabetes mellitus.
Lee YJ, Lo FS, Shu SG, Wang CH, Huang CY, Liu HF, Wu CC, Yang TY, Chang JG
J Pediatr Endocrinol Metab. 2001
PubMed ID: 11327371
CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice.
Bergman ML, Cilio CM, Penha-Gonçalves C, Lamhamedi-Cherradi SE, Löfgren A, Colucci F, Lejon K, Garchon HJ, Holmberg D
J Autoimmun. 2001
PubMed ID: 11247636
The codon 17 polymorphism of the CTLA4 gene in type 2 diabetes mellitus.
Rau H, Braun J, Donner H, Seissler J, Siegmund T, Usadel KH, Badenhoop K
J Clin Endocrinol Metab. 2001
PubMed ID: 11158025
Prevalence of CTLA-4 polymorphism A49G in Ashkenazi Jews.
Mack R, Chowdary D, Samaan P, Podolak I, Dermody J
Genet Test. 2001
PubMed ID: 11788096
No association of type 1 diabetes with a microsatellite marker for CTLA-4 in a Japanese population.
Ban Y, Taniyama M, Tozaki T, Yanagawa T, Yamada S, Maruyama T, Kasuga A, Tomita M, Ban Y
Autoimmunity. 2001
PubMed ID: 11681491
CTLA4 gene polymorphisms are associated with, and linked to, insulin-dependent diabetes mellitus in a Russian population.
Chistiakov DA, Savost'anov KV, Nosikov VV
BMC Genet. 2001
PubMed ID: 11286636
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells.
Luhder F, Chambers C, Allison JP, Benoist C, Mathis D
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11035773
The CTLA4/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders.
Naluai AT, Nilsson S, Samuelsson L, Gudjónsdóttir AH, Ascher H, Ek J, Hallberg B, Kristiansson B, Martinsson T, Nerman O, Sollid LM, Wahlström J
Tissue Antigens. 2000
PubMed ID: 11098935
The length of the CTLA-4 microsatellite (AT)N-repeat affects the risk for type 1 diabetes. Diabetes Incidence in Sweden Study Group.
Lowe RM, Graham J, Sund G, Kockum I, Landin-Olsson M, Schaefer JB, Törn C, Lernmark A, Dahlquist G
Autoimmunity. 2000
PubMed ID: 11092697
NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.
Hill NJ, Lyons PA, Armitage N, Todd JA, Wicker LS, Peterson LB
Diabetes. 2000
PubMed ID: 11016460
Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathy.
Brayer J, Lowry J, Cha S, Robinson CP, Yamachika S, Peck AB, Humphreys-Beher MG
J Rheumatol. 2000
PubMed ID: 10955330
CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis.
Agarwal K, Jones DE, Daly AK, James OF, Vaidya B, Pearce S, Bassendine MF
J Hepatol. 2000
PubMed ID: 10782900
Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation.
Dahlén E, Hedlund G, Dawe K
J Immunol. 2000
PubMed ID: 10679081
Genetics of autoimmune diabetes in animal models.
McDuffie M
Curr Opin Immunol. 1998
PubMed ID: 9914220
No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies.
Heward JM, Allahabadia A, Carr-Smith J, Daykin J, Cockram CS, Gordon C, Barnett AH, Franklyn JA, Gough SC
Clin Endocrinol (Oxf). 1998
PubMed ID: 9861324
CTLA-4 promoter variants in patients with Graves' disease and Hashimoto's thyroiditis.
Braun J, Donner H, Siegmund T, Walfish PG, Usadel KH, Badenhoop K
Tissue Antigens. 1998
PubMed ID: 9672157
Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups.
Marron MP, Raffel LJ, Garchon HJ, Jacob CO, Serrano-Rios M, Martinez Larrad MT, Teng WP, Park Y, Zhang ZX, Goldstein DR, Tao YW, Beaurain G, Bach JF, Huang HS, Luo DF, Zeidler A, Rotter JI, Yang MC, Modilevsky T, Maclaren NK, She JX
Hum Mol Genet. 1997
PubMed ID: 9259273
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry.
Nisticò L, Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C, Bosi E, Larrad MT, Rios MS, Chow CC, Cockram CS, Jacobs K, Mijovic C, Bain SC, Barnett AH, Vandewalle CL, Schuit F, Gorus FK, Tosi R, Pozzilli P, Todd JA
Hum Mol Genet. 1996
PubMed ID: 8817351

Publications: 826

Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity.
Liu SM, Sutherland AP, Zhang Z, Rainbow DB, Quintana FJ, Paterson AM, Sharpe AH, Oukka M, Wicker LS, Kuchroo VK
J Immunol. 2012
PubMed ID: 22124121
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.
Walker LS, Sansom DM
Nat Rev Immunol. 2011
PubMed ID: 22116087
Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in infants.
Rabe H, Lundell AC, Andersson K, Adlerberth I, Wold AE, Rudin A
J Leukoc Biol. 2011
PubMed ID: 21934066
Cytotoxic T-lymphocyte antigen-4 polymorphisms and susceptibility to osteosarcoma.
Liu Y, He Z, Feng D, Shi G, Gao R, Wu X, Song W, Yuan W
DNA Cell Biol. 2011
PubMed ID: 21612409
Th3 immune responses in the progression of leprosy via molecular cross-talks of TGF-β, CTLA-4 and Cbl-b.
Kumar S, Naqvi RA, Khanna N, Pathak P, Rao DN
Clin Immunol. 2011
PubMed ID: 21807564
CTLA-4 exon 1 +49 polymorphism alone and in a haplotype with -318 promoter polymorphism may confer susceptibility to chronic HBV infection in Chinese Han patients.
Duan S, Zhang G, Han Q, Li Z, Liu Z, Chen J, Lv Y, Li N, Wang Y, Li M, Lou S, Yang M, Zhu Q, Xing F
Mol Biol Rep. 2011
PubMed ID: 21161390
[The role of co-inhibitory signals driven by CTLA-4 in immune system].
Olive D, le Thi S, Xerri L, Hirsch I, Nunès JA
Med Sci (Paris). 2011
PubMed ID: 22027421
CTLA-4 +49 A/G gene polymorphism in Croatian and Slovenian multiple sclerosis patients.
Cizmarević NS, Gašparović I, Peterlin B, Sepčić J, Rudolf G, Kapović M, Lavtar P, Ristić S
Int J Immunogenet. 2011
PubMed ID: 21797987
Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese population.
Danoy P, Wei M, Johanna H, Jiang L, He D, Sun L, Zeng X, Visscher PM, Brown MA, Xu H
Ann Rheum Dis. 2011
PubMed ID: 21784728
CTLA-4, CD28, and ICOS gene polymorphism associations with non-small-cell lung cancer.
Karabon L, Pawlak E, Tomkiewicz A, Jedynak A, Passowicz-Muszynska E, Zajda K, Jonkisz A, Jankowska R, Krzakowski M, Frydecka I
Hum Immunol. 2011
PubMed ID: 21669243
Genetic polymorphisms in CTLA4 and SLC4A2 are differentially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients.
Aiba Y, Nakamura M, Joshita S, Inamine T, Komori A, Yoshizawa K, Umemura T, Horie H, Migita K, Yatsuhashi H, Nakamuta M, Fukushima N, Saoshiro T, Hayashi S, Kouno H, Ota H, Muro T, Watanabe Y, Nakamura Y, Komeda T, Shimada M, Masaki N, Komatsu T, Yagura M, Sugi K, Koga M, Tsukamoto K, Tanaka E, Ishibashi H, PBC Study Group in NHOSLJ
J Gastroenterol. 2011
PubMed ID: 21594562
CTLA4 exon1 A49G polymorphism in Slovak patients with rheumatoid arthritis and Hashimoto thyroiditis-results and the review of the literature.
Benhatchi K, Jochmanová I, Habalová V, Wagnerová H, Lazúrová I
Clin Rheumatol. 2011
PubMed ID: 21503616
Polymorphisms in the cytotoxic T-lymphocyte antigen 4 gene and cancer risk: a meta-analysis.
Zhang Y, Zhang J, Deng Y, Tian C, Li X, Huang J, Fan H
Cancer. 2011
PubMed ID: 21387262
Association between CTLA-4 polymorphisms and the susceptibility to systemic lupus erythematosus and Graves' disease in Thai population.
Kimkong I, Nakkuntod J, Sae-Ngow S, Snabboon T, Avihingsanon Y, Hirankarn N
Asian Pac J Allergy Immunol. 2011
PubMed ID: 22053592
Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation.
Wing K, Yamaguchi T, Sakaguchi S
Trends Immunol. 2011
PubMed ID: 21723783
Interaction between CTLA4 gene and IBD5 locus in Hungarian Crohn's disease patients.
Csöngei V, Járomi L, Sáfrány E, Sipeky C, Magyari L, Polgár N, Bene J, Sarlós P, Lakner L, Baricza E, Szabó M, Rappai G, Melegh B
Int J Colorectal Dis. 2011
PubMed ID: 21519805
Prostate cancer immunotherapy.
May KF, Gulley JL, Drake CG, Dranoff G, Kantoff PW
Clin Cancer Res. 2011
PubMed ID: 21700764
Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population.
Idris ZM, Miswan N, Muhi J, Mohd TA, Kun JF, Noordin R
Hum Immunol. 2011
PubMed ID: 21513760
Cytotoxic T-lymphocyte antigen-4 +49G/A polymorphism is associated with increased risk of osteosarcoma.
Wang W, Wang J, Song H, Liu J, Song B, Cao X
Genet Test Mol Biomarkers. 2011
PubMed ID: 21453059
Roles of CD28, CTLA4, and inducible costimulator in acute graft-versus-host disease in mice.
Li J, Semple K, Suh WK, Liu C, Chen F, Blazar BR, Yu XZ
Biol Blood Marrow Transplant. 2011
PubMed ID: 21447398
[Single nucleotide polymorphisms of CTLA4 gene and their association with human cervical cancer].
Jiang L, Luo RY, Zhang W, Wang LR, Wang F, Cheng YX
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011
PubMed ID: 21644231
Analysis of CTLA4 gene variant in infertile Brazilian women with and without endometriosis.
Lerner TG, Bianco B, Teles JS, Vilarino FL, Christofolini DM, Barbosa CP
Int J Immunogenet. 2011
PubMed ID: 21599853
Blockade of CTLA-4 decreases the generation of multifunctional memory CD4+ T cells in vivo.
Rudolph M, Hebel K, Miyamura Y, Maverakis E, Brunner-Weinzierl MC
J Immunol. 2011
PubMed ID: 21478403
Ex vivo transfer of adenovirus-mediated CTLA4Ig gene combined with a short course of rapamycin therapy prolongs free flap allograft survival.
Xiao B, Xia W, Zhao K, Yang Y, Fu S, Li Y, Liu B, Guo S
Plast Reconstr Surg. 2011
PubMed ID: 21532411
Genetic variants in CTLA4 are strongly associated with alopecia areata.
John KK, Brockschmidt FF, Redler S, Herold C, Hanneken S, Eigelshoven S, Giehl KA, De Weert J, Lutz G, Kruse R, Wolff H, Blaumeiser B, Böhm M, Becker T, Nöthen MM, Betz RC
J Invest Dermatol. 2011
PubMed ID: 21346773
Association of cytotoxic T lymphocyte associated antigen-4 gene (rs60872763) polymorphism with Crohn's disease and high levels of serum sCTLA-4 in Crohn's disease.
Chen Z, Zhou F, Huang S, Jiang T, Chen L, Ge L, Xia B
J Gastroenterol Hepatol. 2011
PubMed ID: 21251066
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, Baker J, Jeffery LE, Kaur S, Briggs Z, Hou TZ, Futter CE, Anderson G, Walker LS, Sansom DM
Science. 2011
PubMed ID: 21474713
Association between CTLA-4 exon-1 +49A>G polymorphism and primary biliary cirrhosis risk: a meta-analysis.
Huang Q, Shao F, Wang C, Qiu LJ, Hu YG, Yu JH
Arch Med Res. 2011
PubMed ID: 21722820
Association of CTLA4, CD28 and ICOS gene polymorphisms with clinicopathologic characteristics of childhood IgA nephropathy in Korean population.
Kim HJ, Chung JH, Kang S, Kim SK, Cho BS, Kim SD, Hahn WH
J Genet. 2011
PubMed ID: 21677403
Association between T-lymphocyte regulatory gene CTLA4 single nucleotide polymorphism at position 49 in exon 1 and HLA-DRB1*08 in Japanese patients with psoriasis vulgaris.
Muto M, Deguchi H, Tanaka A, Inoue T, Ichimiya M
J Dermatol Sci. 2011
PubMed ID: 21316924
CTLA4 A49G polymorphism shows significant association with glioma risk in a Chinese population.
Wu Q, Zhan X, Dou T, Chen H, Fan W, Zhou K, Zhang H, Zheng H, Cai Y, Zhao Y, Huang F, Zhou L, Mao Y, Lu D
Biochem Genet. 2011
PubMed ID: 21165767
Haplotype analysis of CTLA4 gene and risk of esophageal squamous cell carcinoma in Anyang area of China.
Cheng XL, Ning T, Xu CQ, Li Y, Zhu BS, Hou FT, Zhang SY, Chen ZP
Hepatogastroenterology. 2011
PubMed ID: 21661409
Polymorphism analysis of the CTLA-4 gene in paracoccidioidomycosis patients.
Lozano VF, Lins TC, Teixeira MM, Vieira RG, Blotta MH, Goes AM, Silva IC, Pereira RW, Bocca AL, Felipe MS
Mem Inst Oswaldo Cruz. 2011
PubMed ID: 21537684
CTLA-4 (CD152) blockade does not cause a pro-inflammatory cytokine profile in regulatory T cells.
Kolar P, Hoff H, Maschmeyer P, Burmester GR, Brunner-Weinzierl MC
Clin Exp Rheumatol. 2011
PubMed ID: 21418778
Immunoregulatory gene polymorphisms in women with preeclampsia.
Pendeloski KP, Sass N, Torloni MR, Mattar R, Moron AF, Franchim CS, Daher S
Hypertens Res. 2011
PubMed ID: 21160481
Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering.
Yu C, Sonnen AF, George R, Dessailly BH, Stagg LJ, Evans EJ, Orengo CA, Stuart DI, Ladbury JE, Ikemizu S, Gilbert RJ, Davis SJ
J Biol Chem. 2011
PubMed ID: 21156796
Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance.
Pedicord VA, Montalvo W, Leiner IM, Allison JP
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21173239
CTLA-4 gene polymorphism and the risk of systemic lupus erythematosus in the Chinese population.
Taha Khalaf A, Song JQ, Gao TT, Yu XP, Lei TC
J Biomed Biotechnol. 2011
PubMed ID: 21915163
Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production.
Curran MA, Kim M, Montalvo W, Al-Shamkhani A, Allison JP
PLoS One. 2011
PubMed ID: 21559358
CTLA4 is expressed on mature dendritic cells derived from human monocytes and influences their maturation and antigen presentation.
Wang XB, Fan ZZ, Anton D, Vollenhoven AV, Ni ZH, Chen XF, Lefvert AK
BMC Immunol. 2011
PubMed ID: 21414236
Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4.
Botturi K, Lacoeuille Y, Cavaillès A, Vervloet D, Magnan A
Respir Res. 2011
PubMed ID: 21356099
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
(AT) repeat in the 3' untranslated region of the CTLA-4 gene and susceptibility to acute allograft rejection in Tunisian renal transplantation.
Krichen H, Sfar I, Hadj Kacem H, Bardi R, Jendoubi-Ayed S, Makhlouf M, Ben Romdhane T, Besseghair F, Aouadi H, Ben Abdallah T, Ayadi H, Ayed K, Gorgi Y
Transplant Proc. 2010
PubMed ID: 21168689
[CTLA-4 gene polymorphism regulates CTLA-4 mRNA stability and protein level in patients with ulcerative colitis].
Chen ZT, Xia B, Jiang T, Zhou F, Zou KF, Ge LQ
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010
PubMed ID: 21154316
CTLA-4 gene polymorphisms (-318C/T, +49A/G, +6230A/G) in Iranian patients with multiple sclerosis.
Heidari A, Noori Daloii MR, Keramatipour M, Rashikinezhad A, Sahmani AA, Amirzargar AA
Iran J Allergy Asthma Immunol. 2010
PubMed ID: 21131701
Effect of cytotoxic T lymphocyte-associated molecule 4 1661 gene polymorphism on its expression and transcription in ulcerative colitis.
Jiang T, Ge LQ, Chen ZT, Li C, Zhou F, Luo Y, Xia B
J Dig Dis. 2010
PubMed ID: 21091900
Association of genetic polymorphisms and risk of late post-transplantation infection in pediatric heart recipients.
Ohmann EL, Brooks MM, Webber SA, Girnita DM, Ferrell RE, Burckart GJ, Chinnock R, Canter C, Addonizio L, Bernstein D, Kirklin JK, Naftel DC, Zeevi A
J Heart Lung Transplant. 2010
PubMed ID: 20869265
Genetically determined amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus.
Sanchez E, Webb RD, Rasmussen A, Kelly JA, Riba L, Kaufman KM, Garcia-de la Torre I, Moctezuma JF, Maradiaga-Ceceña MA, Cardiel-Rios MH, Acevedo E, Cucho-Venegas M, Garcia MA, Gamron S, Pons-Estel BA, Vasconcelos C, Martin J, Tusié-Luna T, Harley JB, Richardson B, Sawalha AH, Alarcón-Riquelme ME
Arthritis Rheum. 2010
PubMed ID: 20848568
Increased CTLA-4 and FOXP3 transcripts in peripheral blood mononuclear cells of patients with breast cancer.
Jaberipour M, Habibagahi M, Hosseini A, Habibabad SR, Talei A, Ghaderi A
Pathol Oncol Res. 2010
PubMed ID: 20306312
Comprehensive Association Analysis of Candidate Genes for Generalized Vitiligo Supports XBP1, FOXP3, and TSLP.
Birlea SA, Jin Y, Bennett DC, Herbstman DM, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Fain PR, Spritz RA
J Invest Dermatol. 2010
PubMed ID: 21085187
CTLA-4, Position 49 A/G Polymorphism Associated with Coronary Artery Lesions in Kawasaki Disease.
Kuo HC, Liang CD, Yu HR, Wang CL, Lin IC, Liu CA, Chang JC, Lee CP, Chang WC, Yang KD
J Clin Immunol. 2010
PubMed ID: 21082224
Effect of donor CTLA-4 alleles and haplotypes on graft-versus-host disease occurrence in Tunisian patients receiving a human leukocyte antigen-identical sibling hematopoietic stem cell transplant.
Sellami MH, Bani M, Torjemane L, Kaabi H, Ladeb S, Othmane TB, Hmida S
Hum Immunol. 2010
PubMed ID: 21081144
Analysis of Immune Regulatory Genes' Copy Number Variants in Graves' Disease.
Huber AK, Concepcion ES, Gandhi A, Menconi F, Smith EP, Keddache M, Tomer Y
Thyroid. 2010
PubMed ID: 21054240
ICOS gene polymorphism may be associated with pemphigus.
Narbutt J, Lesiak A, Klich I, Torzecka JD, Sysa-Jedrzejowska A, Młynarski W
J Cutan Med Surg. 2010
PubMed ID: 21084022
IL1/IL1 Ra, CTLA-4 and Apo1/Fas genes polymorphisms and susceptibility to IgA nephropathy in Tunisian patients.
Gorgi Y, Sfar I, Goucha R, Aouadi H, Amri M, Makhlouf M, Ben Romdhane T, Cherif M, Jendoubi-Ayed S, Ben Abdallah T, Ayed K
Tunis Med. 2010
PubMed ID: 21049406
CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease.
Liu Y, Liang WB, Gao LB, Pan XM, Chen TY, Wang YY, Xue H, Zhang LS, Zhang L
Hum Immunol. 2010
PubMed ID: 20732370
New insights of CTLA-4 into its biological function in breast cancer.
Mao H, Zhang L, Yang Y, Zuo W, Bi Y, Gao W, Deng B, Sun J, Shao Q, Qu X
Curr Cancer Drug Targets. 2010
PubMed ID: 20578982
CTLA-4 confers a risk of recurrent schizophrenia, major depressive disorder and bipolar disorder in the Chinese Han population.
Liu J, Li J, Li T, Wang T, Li Y, Zeng Z, Li Z, Chen P, Hu Z, Zheng L, Ji J, Feng G, Shi Y
Brain Behav Immun. 2010
PubMed ID: 21040781
Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with idiopathic thrombocytopenic purpura in a Chinese population.
Li H, Ge J, Zhao H, Du W, Xu J, Sui T, Ma L, Zhou Z, Qi A, Yang R
Platelets. 2010
PubMed ID: 21034161
Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans.
Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL
Arthritis Rheum. 2010
PubMed ID: 20973039
Polymorphisms of the CTLA4 gene and kidney transplant rejection in Korean patients.
Kim HJ, Jeong KH, Lee SH, Moon JY, Lee TW, Kang SW, Park SJ, Kim YH, Chung JH
Transpl Immunol. 2010
PubMed ID: 20940051
CTLA-4 is expressed by human monocyte-derived dendritic cells and regulates their functions.
Laurent S, Carrega P, Saverino D, Piccioli P, Camoriano M, Morabito A, Dozin B, Fontana V, Simone R, Mortara L, Mingari MC, Ferlazzo G, Pistillo MP
Hum Immunol. 2010
PubMed ID: 20650297
Elevated mRNA levels of CTLA-4, FoxP3, and granzyme B in BAL, but not in blood, during acute rejection of lung allografts.
Madsen CB, Nørgaard A, Iversen M, Ryder LP
Transpl Immunol. 2010
PubMed ID: 20633650
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
ctla-4 gene variations may influence cervical cancer susceptibility.
Rahimifar S, Erfani N, Sarraf Z, Ghaderi A
Gynecol Oncol. 2010
PubMed ID: 20615526
Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
Ucisik-Akkaya E, Davis CF, Do TN, Morrison BA, Stemmer SM, Amadio WJ, Tevfik Dorak M
Mol Hum Reprod. 2010
PubMed ID: 20587610
Circulating soluble CTLA4 (sCTLA4) is elevated in patients with breast cancer.
Erfani N, Razmkhah M, Ghaderi A
Cancer Invest. 2010
PubMed ID: 20482250
Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.
Webb R, Kelly JA, Somers EC, Hughes T, Kaufman KM, Sanchez E, Nath SK, Bruner G, Alarcón-Riquelme ME, Gilkeson GS, Kamen DL, Richardson BC, Harley JB, Sawalha AH
Ann Rheum Dis. 2010
PubMed ID: 20881011
Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation.
Yokosuka T, Kobayashi W, Takamatsu M, Sakata-Sogawa K, Zeng H, Hashimoto-Tane A, Yagita H, Tokunaga M, Saito T
Immunity. 2010
PubMed ID: 20870175
Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
Chang JS, Wiemels JL, Chokkalingam AP, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Green J, May SL, Kiley VA, Wiencke JK, Buffler PA
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20716621
CTLA4 CT60 A/G gene polymorphism in liver transplant recipients.
Azarpira N, Malekhosseini SA, Aghdaie MH, Daraie M
Exp Clin Transplant. 2010
PubMed ID: 20716038
Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients.
Joshita S, Umemura T, Yoshizawa K, Katsuyama Y, Tanaka E, Nakamura M, Ishibashi H, Ota M, Shinshu PBC Study Group
J Hepatol. 2010
PubMed ID: 20557968
Genetic variants in the prediction of rheumatoid arthritis.
van der Helm-van Mil AH, Toes RE, Huizinga TW
Ann Rheum Dis. 2010
PubMed ID: 20439292
The cytotoxic lymphocyte antigen 4 polymorphisms affect response to hepatitis C virus-specific therapy in HIV(+) patients with acute and chronic hepatitis C virus co-infection.
Nischalke HD, Vogel M, Mauss S, Baumgarten A, Lutz T, Danta M, Naumann U, Coenen M, Sauerbruch T, Rockstroh JK, Spengler U, Nattermann J
AIDS. 2010
PubMed ID: 20588168
[Expression and significance of gp96 and immune-related gene CTLA-4, CD8 in lung cancer tissues].
Zheng H, Li Y, Wang X, Zhang X, Wang X
Zhongguo Fei Ai Za Zhi. 2010
PubMed ID: 20704820
[Association of CTLA4 gene +49G/A polymorphism with HBV infection and HBV-related hepatocellular carcinoma in Hunan Han population].
Liu G, Lu GX
Nan Fang Yi Ke Da Xue Xue Bao. 2010
PubMed ID: 20813679
Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism.
Beckers MM, Ruven HJ, Haas FJ, Doevendans PA, ten Cate H, Prins MH, Biesma DH
Eur J Intern Med. 2010
PubMed ID: 20603037
Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.
Ying H, Yang L, Qiao G, Li Z, Zhang L, Yin F, Xie D, Zhang J
J Immunol. 2010
PubMed ID: 20601598
Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.
Plant D, Flynn E, Mbarek H, Dieudé P, Cornelis F, Arlestig L, Dahlqvist SR, Goulielmos G, Boumpas DT, Sidiropoulos P, Johansen JS, Ørnbjerg LM, Hetland ML, Klareskog L, Filer A, Buckley CD, Raza K, Witte T, Schmidt RE, Worthington J
Ann Rheum Dis. 2010
PubMed ID: 20498205
Genetic polymorphisms of the T-cell coreceptors CD28 and CTLA-4 in Afro- and Euro-Brazilians.
Pincerati MR, Dalla-Costa R, Pavoni DP, Petzl-Erler ML
Int J Immunogenet. 2010
PubMed ID: 20477885
Polymorphisms in the 2q33 and 3q21 chromosome regions including T-cell coreceptor and ligand genes may influence susceptibility to pemphigus foliaceus.
Dalla-Costa R, Pincerati MR, Beltrame MH, Malheiros D, Petzl-Erler ML
Hum Immunol. 2010
PubMed ID: 20433886
Cytotoxic T lymphocyte antigen-4 (CTLA-4) polymorphism in patients with Behçet's disease.
Düzgün N, Duman T, Keskin O, Morris Y, Tutkak H
Clin Exp Rheumatol. 2010
PubMed ID: 20868585
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM
Nature. 2010
PubMed ID: 20596022
Carriage of a tumor necrosis factor polymorphism amplifies the cytotoxic T-lymphocyte antigen 4 attributed risk of primary biliary cirrhosis: evidence for a gene-gene interaction.
Juran BD, Atkinson EJ, Larson JJ, Schlicht EM, Liu X, Heathcote EJ, Hirschfield GM, Siminovitch KA, Lazaridis KN
Hepatology. 2010
PubMed ID: 20578265
The influence of CTLA-4 gene polymorphism on long-term kidney allograft function in Caucasian recipients.
Kusztal M, Kościelska-Kasprzak K, Drulis-Fajdasz D, Magott-Procelewska M, Patrzałek D, Janczak D, Chudoba P, Klinger M
Transpl Immunol. 2010
PubMed ID: 20470888
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
Association of T-cell regulatory gene polymorphisms with oral squamous cell carcinoma.
Kämmerer PW, Toyoshima T, Schöder F, Kämmerer P, Kuhr K, Brieger J, Al-Nawas B
Oral Oncol. 2010
PubMed ID: 20435510
Association of CT60 cytotoxic T lymphocyte antigen-4 gene polymorphism with thyroid autoantibody production in patients with Hashimoto's and postpartum thyroiditis.
Zaletel K, Krhin B, Gaberscek S, Bicek A, Pajic T, Hojker S
Clin Exp Immunol. 2010
PubMed ID: 20408864
Circulating soluble CTLA-4 is related to inflammatory markers in the 70 year old population.
Sakthivel P, Wermeling F, Elmgren A, Hulthe J, Kakoulidou M, Lefvert AK, Lind L
Scand J Clin Lab Invest. 2010
PubMed ID: 20331384
CTLA-4 gene polymorphism +49 A/G contributes to genetic susceptibility to two infection-related cancers-hepatocellular carcinoma and cervical cancer.
Hu L, Liu J, Chen X, Zhang Y, Liu L, Zhu J, Chen J, Shen H, Qiang F, Hu Z
Hum Immunol. 2010
PubMed ID: 20538028
Domain metastability: a molecular basis for immunoglobulin deposition?
Sonnen AF, Yu C, Evans EJ, Stuart DI, Davis SJ, Gilbert RJ
J Mol Biol. 2010
PubMed ID: 20394753
Investigation of CTLA-4 and CD28 gene polymorphisms in patients with diabetes mellitus type 2 using PCR-RFLP in a Turkish population.
Uzer E, Dilmec F, Akkafa F, Boduroglu O, van Kuilenburg AB
West Indian Med J. 2010
PubMed ID: 21291098
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
Pediatr Pulmonol. 2010
PubMed ID: 20503287
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, YEAR Consortium, Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM
Nat Genet. 2010
PubMed ID: 20453842
Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.
Tan RJ, Gibbons LJ, Potter C, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, BRAGGSS, Barton A
Ann Rheum Dis. 2010
PubMed ID: 20444755
Surfactant protein D-mediated decrease of allergen-induced inflammation is dependent upon CTLA4.
Lin KW, Jen KY, Suarez CJ, Crouch EC, Perkins DL, Finn PW
J Immunol. 2010
PubMed ID: 20435925
CTLA-4 (CD152) inhibits T cell function by activating the ubiquitin ligase Itch.
Hoff H, Kolar P, Ambach A, Radbruch A, Brunner-Weinzierl MC
Mol Immunol. 2010
PubMed ID: 20417562
Replication of genetic association studies in asthma and related phenotypes.
Undarmaa S, Mashimo Y, Hattori S, Shimojo N, Fujita K, Miyatake A, Doi S, Kohno Y, Okamoto Y, Hirota T, Tamari M, Hata A, Suzuki Y
J Hum Genet. 2010
PubMed ID: 20395963
Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.
Sombekke MH, Arteta D, van de Wiel MA, Crusius JB, Tejedor D, Killestein J, Martínez A, Peña AS, Polman CH, Uitdehaag BM
Mult Scler. 2010
PubMed ID: 20378664
A screen for endocytic motifs.
Kozik P, Francis RW, Seaman MN, Robinson MS
Traffic. 2010
PubMed ID: 20214754
CTLA-4 +49A>G polymorphism of recipients of HLA-matched sibling allogeneic stem cell transplantation is associated with survival and relapse incidence.
Piccioli P, Balbi G, Serra M, Morabito A, Lamparelli T, Gobbi M, Laurent S, Dozin B, Bruzzi P, Ferraris AM, Bacigalupo A, Notaro R, Pistillo MP
Ann Hematol. 2010
PubMed ID: 20020126
CTLA4 CT60 Single-Nucleotide Polymorphism Is Associated with Slovenian Inflammatory Bowel Disease Patients and Regulates Expression of CTLA4 Isoforms.
Repnik K, Potočnik U
DNA Cell Biol. 2010
PubMed ID: 20491567
T cell pathways involving CTLA4 contribute to a model of acute lung injury.
Nakajima T, Suarez CJ, Lin KW, Jen KY, Schnitzer JE, Makani SS, Parker N, Perkins DL, Finn PW
J Immunol. 2010
PubMed ID: 20385880
CTLA4 -1661A/G and 3'UTR long repeat polymorphisms are associated with ulcerative colitis and influence CTLA4 mRNA and protein expression.
Chen Z, Brant SR, Li C, Shrestha UK, Jiang T, Zhou F, Jiang Y, Shi X, Zhao Y, Li J, Xia B
Genes Immun. 2010
PubMed ID: 20445568
The +49A>G CTLA-4 polymorphism is associated with rheumatoid arthritis in Mexican population.
Muñoz-Valle JF, Valle Y, Padilla-Gutiérrez JR, Parra-Rojas I, Rangel-Villalobos H, Vázquez del Mercado M, Ledezma-Lozano IY, Villafan-Bernal JR, Armendáriz-Borunda J, Pereira-Suárez AL
Clin Chim Acta. 2010
PubMed ID: 20138855
[The analysis of 49A/G CTLA4 gene polymorphism association with development of allergic rhinitis].
Alieva VSh, Karimov KhIa, Nazarov AA, Arifov SS, Boboev KT
Tsitol Genet. 2010
PubMed ID: 20608155
Genetic markers in acquired haemophilia.
Oldenburg J, Zeitler H, Pavlova A
Haemophilia. 2010
PubMed ID: 20586801
CD4+CD25+Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia.
Winstead CJ, Reilly CS, Moon JJ, Jenkins MK, Hamilton SE, Jameson SC, Way SS, Khoruts A
J Immunol. 2010
PubMed ID: 20357265
Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL
J Infect Dis. 2010
PubMed ID: 20331378
Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients.
Wang Y, Luk AO, Ma RC, So WY, Tam CH, Ng MC, Yang X, Baum L, Lam V, Tong PC, Chan JC
Diabet Med. 2010
PubMed ID: 20536507
Association Between Serum IgE Levels and the CTLA4 +49A/G and FCER1B -654C/T Polymorphisms in Korean Children With Asthma.
Oh KY, Kang MJ, Choi WA, Kwon JW, Kim BJ, Yu J, Hong SJ
Allergy Asthma Immunol Res. 2010
PubMed ID: 20358027
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
Multiple common variants for celiac disease influencing immune gene expression.
Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA
Nat Genet. 2010
PubMed ID: 20190752
HLA-DRB1*11: a strong risk factor for acquired severe ADAMTS13 deficiency-related idiopathic thrombotic thrombocytopenic purpura in Caucasians.
Coppo P, Busson M, Veyradier A, Wynckel A, Poullin P, Azoulay E, Galicier L, Loiseau P, French Reference Centre For Thrombotic Microangiopathies
J Thromb Haemost. 2010
PubMed ID: 20141578
Study of the CTLA-4 gene polymorphisms in systemic lupus erythematosus (SLE) samples from Malaysia.
Chua KH, Puah SM, Chew CH, Tan SY, Lian LH
Ann Hum Biol. 2010
PubMed ID: 19951233
HLA and CTLA4 polymorphisms may confer a synergistic risk in the susceptibility to Graves' disease.
Takahashi M, Kimura A
J Hum Genet. 2010
PubMed ID: 20300120
Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.
Karlson EW, Chibnik LB, Kraft P, Cui J, Keenan BT, Ding B, Raychaudhuri S, Klareskog L, Alfredsson L, Plenge RM
Ann Rheum Dis. 2010
PubMed ID: 20233754
The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register.
Plant D, Thomson W, Lunt M, Flynn E, Martin P, Eyre S, Farragher T, Bunn D, Worthington J, Symmons D, Barton A
Rheumatology (Oxford). 2010
PubMed ID: 20219786
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors.
Curran MA, Montalvo W, Yagita H, Allison JP
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20160101
Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis.
Kim YO, Kim HJ, Kim SK, Chung JH, Hong SJ
Clin Chem Lab Med. 2010
PubMed ID: 20113255
Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population.
Chen DQ, Zeng Y, Zhou J, Yang L, Jiang S, Huang JD, Lu L, Zheng BJ
J Med Virol. 2010
PubMed ID: 20087947
Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis.
Hinks A, Eyre S, Ke X, Barton A, Martin P, Flynn E, Packham J, Worthington J, Childhood Arthritis Prospective Study, UKRAG Consortium, BSPAR Study Group, Thomson W
Genes Immun. 2010
PubMed ID: 20072139
Association of CTLA4 gene polymorphism in Iranian patients with ankylosing spondylitis.
Azizi E, Massoud A, Amirzargar AA, Mahmoudi M, Soleimanifar N, Rezaei N, Jamshidi AR, Nikbin B, Nicknam MH
J Clin Immunol. 2010
PubMed ID: 20012554
Interaction of immunological genes on chromosome 2q33 and IFNG in susceptibility to cervical cancer.
Ivansson EL, Juko-Pecirep I, Gyllensten UB
Gynecol Oncol. 2010
PubMed ID: 19959217
Functional polymorphism in CTLA4 gene influences the response to therapy with inhaled corticosteroids in Slovenian children with atopic asthma.
Berce V, Potocnik U
Biomarkers. 2010
PubMed ID: 19895365
Evidence for CTLA4 as a susceptibility gene for dilated cardiomyopathy.
Ruppert V, Meyer T, Struwe C, Petersen J, Perrot A, Posch MG, Ozcelik C, Richter A, Maisch B, Pankuweit S
Eur J Hum Genet. 2010
PubMed ID: 20145677
Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation.
Poirier N, Azimzadeh AM, Zhang T, Dilek N, Mary C, Nguyen B, Tillou X, Wu G, Reneaudin K, Hervouet J, Martinet B, Coulon F, Allain-Launay E, Karam G, Soulillou JP, Pierson RN, Blancho G, Vanhove B
Sci Transl Med. 2010
PubMed ID: 20371478
[Interactions between susceptible genes and risk environmental factors in Chinese females with systemic lupus erythematosus]
Peng CL, Jiang F, Wang BT, Yang XH, Qin WZ, Xu AE, Meng W
Zhonghua Yu Fang Yi Xue Za Zhi. 2010
PubMed ID: 20388336
CTLA4 polymorphisms and COPD.
Wood AM, Newby PR, Gough SC, Stockley RA
Eur Respir J. 2010
PubMed ID: 20123855
CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.
Ise W, Kohyama M, Nutsch KM, Lee HM, Suri A, Unanue ER, Murphy TL, Murphy KM
Nat Immunol. 2010
PubMed ID: 20037585
Polymorphisms of cytotoxic T lymphocyte-associated antigen-4 and cytokine genes in Taiwanese patients with ankylosing spondylitis.
Lee WY, Chang YH, Lo MK, Chang CP, Yang SC, Yang TP, Ho KT, Juan CW, Shiau MY
Tissue Antigens. 2010
PubMed ID: 20030788
Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus.
Jury EC, Flores-Borja F, Kalsi HS, Lazarus M, Isenberg DA, Mauri C, Ehrenstein MR
Eur J Immunol. 2010
PubMed ID: 19950182
Functional polymorphism of cytotoxic T-lymphocyte antigen 4 and nasopharyngeal carcinoma susceptibility in a Chinese population.
Xiao M, Qi F, Chen X, Luo Z, Zhang L, Zheng C, Hu S, Jiang X, Zhou M, Tang J
Int J Immunogenet. 2010
PubMed ID: 19922464
Influence of CTLA-4/CD28/ICOS gene polymorphisms on the susceptibility to cervical squamous cell carcinoma and stage of differentiation in the Polish population.
Pawlak E, Karabon L, Wlodarska-Polinska I, Jedynak A, Jonkisz A, Tomkiewicz A, Kornafel J, Stepien M, Ignatowicz A, Lebioda A, Dobosz T, Frydecka I
Hum Immunol. 2010
PubMed ID: 19913589
Cytotoxic T lymphocyte antigen-4 Ala17 polymorphism is a genetic marker of autoimmune adrenal insufficiency: Italian association study and meta-analysis of European studies.
Brozzetti A, Marzotti S, Tortoioli C, Bini V, Giordano R, Dotta F, Betterle C, De Bellis A, Arnaldi G, Toscano V, Arvat E, Bellastella A, Mantero F, Falorni A, Italian Addison Network
Eur J Endocrinol. 2010
PubMed ID: 19884265
Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus.
Järvinen TM, Hellquist A, Koskenmies S, Einarsdottir E, Koskinen LL, Jeskanen L, Berglind L, Panelius J, Hasan T, Ranki A, Kere J, Saarialho-Kere U
Exp Dermatol. 2010
PubMed ID: 19758313
Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease.
Gu LQ, Zhu W, Zhao SX, Zhao L, Zhang MJ, Cui B, Song HD, Ning G, Zhao YJ
Clin Endocrinol (Oxf). 2010
PubMed ID: 19438904
Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity.
Jain N, Nguyen H, Chambers C, Kang J
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20080649
CTLA4 gene variations and haplotypes in patients with lung cancer.
Khaghanzadeh N, Erfani N, Ghayumi MA, Ghaderi A
Cancer Genet Cytogenet. 2010
PubMed ID: 20082854
PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis.
Ishizaki Y, Yukaya N, Kusuhara K, Kira R, Torisu H, Ihara K, Sakai Y, Sanefuji M, Pipo-Deveza JR, Silao CL, Sanchez BC, Lukban MB, Salonga AM, Hara T
Hum Genet. 2010
PubMed ID: 20066438
FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells.
Schildknecht A, Brauer S, Brenner C, Lahl K, Schild H, Sparwasser T, Probst HC, van den Broek M
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20018763
CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo.
Haque A, Best SE, Amante FH, Mustafah S, Desbarrieres L, de Labastida F, Sparwasser T, Hill GR, Engwerda CR
PLoS Pathog. 2010
PubMed ID: 21170302
CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice.
Liu F, Liu J, Weng D, Chen Y, Song L, He Q, Chen J
PLoS One. 2010
PubMed ID: 21072213
Evaluation of six CTLA-4 polymorphisms in high-risk melanoma patients receiving adjuvant interferon therapy in the He13A/98 multicenter trial.
Gogas H, Dafni U, Koon H, Spyropoulou-Vlachou M, Metaxas Y, Buchbinder E, Pectasides E, Tsoutsos D, Polyzos A, Stratigos A, Markopoulos C, Panagiotou P, Fountzilas G, Castana O, Skarlos P, Atkins MB, Kirkwood JM
J Transl Med. 2010
PubMed ID: 21044351
Association between the Cytotoxic T-lymphocyte antigen 4 +49G > A polymorphism and cancer risk: a meta-analysis.
Zheng J, Yu X, Jiang L, Xiao M, Bai B, Lu J, Zhou Y
BMC Cancer. 2010
PubMed ID: 20920330
Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
Cross DS, Ivacic LC, Stefanski EL, McCarty CA
BMC Genet. 2010
PubMed ID: 20565774
The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease.
Hradsky O, Dusatkova P, Lenicek M, Bronsky J, Nevoral J, Vitek L, Lukas M, Zeniskova I, Cinek O
BMC Med Genet. 2010
PubMed ID: 20537165
CTLA-4 A49G gene polymorphism is not associated with vitiligo in South Indian population.
Deeba F, Syed R, Quareen J, Waheed MA, Jamil K, Rao H
Indian J Dermatol. 2010
PubMed ID: 20418973
Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
Ban HJ, Heo JY, Oh KS, Park KJ
BMC Genet. 2010
PubMed ID: 20416077
Association of the CTLA4 gene with Graves' disease in the Chinese Han population.
Zhao SX, Pan CM, Cao HM, Han B, Shi JY, Liang J, Gao GQ, Peng YD, Su Q, Chen JL, Zhao JJ, Song HD
PLoS One. 2010
PubMed ID: 20352109
Cytotoxic T-lymphocyte-associated antigen 4 gene polymorphisms in Japanese children with infection-associated hemophagocytic lymphohistiocytosis.
Yoshiyama M, Kounami S, Nakayama K, Okutani T, Aoyagi N, Yoshikawa N
Acta Haematol. 2010
PubMed ID: 20224272
Association of plasma soluble CTLA-4 with lung function and gene polymorphism in Chinese asthmatic children.
Chan IH, Tang NL, Leung TF, Lam YY, Wong GW, Wong CK, Lam CW
Int Arch Allergy Immunol. 2010
PubMed ID: 20016193
CTLA-4 +49A>G polymorphism is associated with the risk but not with the progression of colorectal cancer in Chinese.
Qi P, Ruan CP, Wang H, Zhou FG, Xu XY, Gu X, Zhao YP, Dou TH, Gao CF
Int J Colorectal Dis. 2010
PubMed ID: 19787358
Association of a functional polymorphism of PTPN22 encoding a lymphoid protein phosphatase in bilateral Meniere's disease.
Lopez-Escamez JA, Saenz-Lopez P, Acosta L, Moreno A, Gazquez I, Perez-Garrigues H, Lopez-Nevot A, Lopez-Nevot MA
Laryngoscope. 2010
PubMed ID: 19780033
+49G > A polymorphism in the cytotoxic T-lymphocyte antigen-4 gene increases susceptibility to hepatitis B-related hepatocellular carcinoma in a male Chinese population.
Gu X, Qi P, Zhou F, Ji Q, Wang H, Dou T, Zhao Y, Gao C
Hum Immunol. 2010
PubMed ID: 19778566
Polymorphisms in genes involved in autoimmune disease and the risk of FVIII inhibitor development in Italian patients with haemophilia A.
Bafunno V, Santacroce R, Chetta M, D'Andrea G, Pisanelli D, Sessa F, Trotta T, Tagariello G, Peyvandi F, Margaglione M
Haemophilia. 2009
PubMed ID: 20015215
Impact of polymorphisms of the major histocompatibility complex class II, interleukin-10, tumor necrosis factor-alpha and cytotoxic T-lymphocyte antigen-4 genes on inhibitor development in severe hemophilia A.
Pavlova A, Delev D, Lacroix-Desmazes S, Schwaab R, Mende M, Fimmers R, Astermark J, Oldenburg J
J Thromb Haemost. 2009
PubMed ID: 19817985
CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis.
Kamesh L, Heward JM, Williams JM, Gough SC, Chavele KM, Salama A, Pusey C, Savage CO, Harper L
Rheumatology (Oxford). 2009
PubMed ID: 19815671
The CD4+CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage.
Jin LP, Chen QY, Zhang T, Guo PF, Li DJ
Clin Immunol. 2009
PubMed ID: 19766059
Expression of CD152 (CTLA-4) in children with autoimmune thyroiditis and +49 A/G polymorphism of exon 1 of the CTLA-4 gene.
Kucharska AM, Gorska E, Wasik M, Pyrzak B, Demkow U
J Physiol Pharmacol. 2009
PubMed ID: 20134044
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Long-term follow-up of autoimmune pancreatitis: characteristics of chronic disease and recurrence.
Kawa S, Hamano H, Ozaki Y, Ito T, Kodama R, Chou Y, Takayama M, Arakura N
Clin Gastroenterol Hepatol. 2009
PubMed ID: 19896092
Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions.
Onodera T, Jang MH, Guo Z, Yamasaki M, Hirata T, Bai Z, Tsuji NM, Nagakubo D, Yoshie O, Sakaguchi S, Takikawa O, Miyasaka M
J Immunol. 2009
PubMed ID: 19843945
Association and interaction analyses of eight genes under asthma linkage peaks.
Ferreira MA, Zhao ZZ, Thomsen SF, James M, Evans DM, Postmus PE, Kyvik KO, Backer V, Boomsma DI, Martin NG, Montgomery GW, Duffy DL
Allergy. 2009
PubMed ID: 19824886
PD-1 but not CTLA-4 blockage abrogates the protective effect of regulatory T cells in a pregnancy murine model.
Wafula PO, Teles A, Schumacher A, Pohl K, Yagita H, Volk HD, Zenclussen AC
Am J Reprod Immunol. 2009
PubMed ID: 19811462
Soluble CTLA-4 receptor an immunological marker of Graves' disease and severity of ophthalmopathy is associated with CTLA-4 Jo31 and CT60 gene polymorphisms.
Daroszewski J, Pawlak E, Karabon L, Frydecka I, Jonkisz A, Slowik M, Bolanowski M
Eur J Endocrinol. 2009
PubMed ID: 19734241
Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP.
Iijima M, Tomita M, Morozumi S, Kawagashira Y, Nakamura T, Koike H, Katsuno M, Hattori N, Tanaka F, Yamamoto M, Sobue G
Neurology. 2009
PubMed ID: 19776380
Genetic polymorphisms of immunoregulatory proteins in acute renal allograft rejection.
Krichen H, Sfar I, Jendoubi-Ayed S, Makhlouf M, Ben Rhomdhane T, Bardi R, Aouadi H, Ben Abdallah T, Ayed K, Gorgi Y
Transplant Proc. 2009
PubMed ID: 19857736
No association of CTLA-4 polymorphisms with susceptibility to Behçet disease.
Du L, Yang P, Hou S, Zhou H, Kijlstra A
Br J Ophthalmol. 2009
PubMed ID: 19570770
49A/G and CT60 polymorphisms of the cytotoxic T-lymphocyte-associated antigen 4 gene associated with autoimmune thyroid disease.
Bicek A, Zaletel K, Gaberscek S, Pirnat E, Krhin B, Stopar TG, Hojker S
Hum Immunol. 2009
PubMed ID: 19559744
Pretibial myxedema is associated with polymorphism in exon 1 of CTLA-4 gene in patients with Graves' ophthalmopathy.
Khalilzadeh O, Mojazi Amiri H, Tahvildari M, Anvari M, Esteghamati A, Mobarra Z, Tehranchinia Z, Rashidi A, Amirzargar A
Arch Dermatol Res. 2009
PubMed ID: 19037649
Cytotoxic T lymphocyte-associated antigen-4 polymorphism in patients with rheumatic heart disease.
Düzgün N, Duman T, Haydardedeoğlu FE, Tutkak H
Tissue Antigens. 2009
PubMed ID: 19737369
CTLA4 exon 1 and promoter polymorphisms in patients with multiple sclerosis.
Yousefipour G, Erfani N, Momtahan M, Moghaddasi H, Ghaderi A
Acta Neurol Scand. 2009
PubMed ID: 19737153
Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions.
Kim SH, Lee JE, Kim SH, Jee YK, Kim YK, Park HS, Min KU, Park HW, The Adverse Drug Reaction Research Group in Korea
Clin Exp Allergy. 2009
PubMed ID: 19735272
The CTLA-4 gene polymorphisms are associated with CTLA-4 protein expression levels in multiple sclerosis patients and with susceptibility to disease.
Karabon L, Kosmaczewska A, Bilinska M, Pawlak E, Ciszak L, Jedynak A, Jonkisz A, Noga L, Pokryszko-Dragan A, Koszewicz M, Frydecka I
Immunology. 2009
PubMed ID: 19740340
Association of polymorphism at position 49 in exon 1 of the cytotoxic T-lymphocyte-associated factor 4 gene with Graves' disease refractory to medical treatment, but not with amiodarone-associated thyroid dysfunction.
Kimura H, Kato Y, Shimizu S, Takano K, Sato K
Thyroid. 2009
PubMed ID: 19731979
A functional soluble form of CTLA-4 is present in the serum of celiac patients and correlates with mucosal injury.
Simone R, Brizzolara R, Chiappori A, Milintenda-Floriani F, Natale C, Greco L, Schiavo M, Bagnasco M, Pesce G, Saverino D
Int Immunol. 2009
PubMed ID: 19625381
CTLA4 gene polymorphisms and soluble CTLA4 protein in Behcet's disease.
Park KS, Baek JA, Do JE, Bang D, Lee ES
Tissue Antigens. 2009
PubMed ID: 19563524
Cytotoxic T-lymphocyte antigen 4 blockade augments the T-cell response primed by attenuated Listeria monocytogenes resulting in more rapid clearance of virulent bacterial challenge.
Rowe JH, Johanns TM, Ertelt JM, Lai JC, Way SS
Immunology. 2009
PubMed ID: 19191906
Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer.
Hou R, Cao B, Chen Z, Li Y, Ning T, Li C, Xu C, Chen Z
Mol Biol Rep. 2009
PubMed ID: 19688278
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies.
Peggs KS, Quezada SA, Chambers CA, Korman AJ, Allison JP
J Exp Med. 2009
PubMed ID: 19581407
[Association of cytotoxic T lymphocyte antigen-4 promoter C-658T polymorphism with ulcerative colitis in Chinese]
Luo Y, Xia B, Li C, Chen ZT, Ge LQ, Jiang T
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009
PubMed ID: 20017310
Genetic polymorphisms in cytotoxic T-lymphocyte antigen 4 and cancer: the dialectical nature of subtle human immune dysregulation.
Sun T, Hu Z, Shen H, Lin D
Cancer Res. 2009
PubMed ID: 19638588
CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer.
Welsh MM, Applebaum KM, Spencer SK, Perry AE, Karagas MR, Nelson HH
Cancer Res. 2009
PubMed ID: 19622768
CTLA-4 gene polymorphism of exon 1(+49 A/G) in Turkish systemic lupus erythematosus patients.
Ulker M, Yazisiz V, Sallakci N, Avci AB, Sanlioglu S, Yegin O, Terzioglu E
Int J Immunogenet. 2009
PubMed ID: 19602000
Association between genotypes and phenotypes in coeliac disease.
Gudjónsdóttir AH, Nilsson S, Naluai AT, Ek J, Amundsen SS, Wahlström J, Ascher H
J Pediatr Gastroenterol Nutr. 2009
PubMed ID: 19543113
Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling.
Song XY, Lee SY, Ma RC, So WY, Cai JH, Tam C, Lam V, Ying W, Ng MC, Chan JC
Diabetologia. 2009
PubMed ID: 19479237
Variation in the lymphotoxin-alpha/tumor necrosis factor locus modifies risk of erythema nodosum in sarcoidosis.
McDougal KE, Fallin MD, Moller DR, Song Z, Cutler DJ, Steiner LL, Cutting GR, ACCESS Research Group
J Invest Dermatol. 2009
PubMed ID: 19225544
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1.
Babu S, Bhat SQ, Kumar NP, Jayantasri S, Rukmani S, Kumaran P, Gopi PG, Kolappan C, Kumaraswami V, Nutman TB
J Infect Dis. 2009
PubMed ID: 19505258
A candidate gene association study of 77 polymorphisms in migraine.
Schürks M, Kurth T, Buring JE, Zee RY
J Pain. 2009
PubMed ID: 19559392
Association of CTLA-4 gene polymorphism with Graves' disease and ophthalmopathy in Iranian patients.
Esteghamati A, Khalilzadeh O, Mobarra Z, Anvari M, Tahvildari M, Amiri HM, Rashidi A, Solgi G, Parivar K, Nikbin B, Amirzargar A
Eur J Intern Med. 2009
PubMed ID: 19524188
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
Gregersen PK, Amos CI, Lee AT, Lu Y, Remmers EF, Kastner DL, Seldin MF, Criswell LA, Plenge RM, Holers VM, Mikuls TR, Sokka T, Moreland LW, Bridges SL, Xie G, Begovich AB, Siminovitch KA
Nat Genet. 2009
PubMed ID: 19503088
Influence of CTLA-4 gene polymorphism in autoimmune and infectious diseases.
Fernández-Mestre M, Sánchez K, Balbás O, Gendzekhzadze K, Ogando V, Cabrera M, Layrisse Z
Hum Immunol. 2009
PubMed ID: 19345707
Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.
Rogers AJ, Raby BA, Lasky-Su JA, Murphy A, Lazarus R, Klanderman BJ, Sylvia JS, Ziniti JP, Lange C, Celedón JC, Silverman EK, Weiss ST
Am J Respir Crit Care Med. 2009
PubMed ID: 19264973
Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal.
Hara S, Nakaseko C, Yamasaki S, Hattori M, Bos JL, Saito Y, Minato N, Saito T
Hematology. 2009
PubMed ID: 19490760
CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation.
Sojka DK, Hughson A, Fowell DJ
Eur J Immunol. 2009
PubMed ID: 19462377
Combination of CTLA-4 and TGFbeta1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak.
Chen RF, Wang L, Cheng JT, Chuang H, Chang JC, Liu JW, Lin IC, Yang KD
Clin Immunol. 2009
PubMed ID: 19269255
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Lentiviral gene transfer of CTLA4 generates B cells with reduced costimulatory properties.
Vogt B, Warncke M, Micheel B, Sheriff A
Autoimmunity. 2009
PubMed ID: 19811307
[Polymorphisms in inflammatory response genes in metastatic renal cancer]
Sáenz López P, Vázquez Alonso F, Romero JM, Carretero R, Tallada Buñuel M, Ruiz Cabello F, Cózar Olmo JM
Actas Urol Esp. 2009
PubMed ID: 19658300
The clinical utility of inhibiting CD28-mediated costimulation.
Linsley PS, Nadler SG
Immunol Rev. 2009
PubMed ID: 19426230
Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis.
Daha NA, Kurreeman FA, Marques RB, Stoeken-Rijsbergen G, Verduijn W, Huizinga TW, Toes RE
Arthritis Rheum. 2009
PubMed ID: 19404967
Surface CD152 (CTLA-4) expression and signaling dictates longevity of CD28null T cells.
Hoff H, Knieke K, Cabail Z, Hirseland H, Vratsanos G, Burmester GR, Jorch G, Nadler SG, Bröker B, Hebel K, Brunner-Weinzierl MC
J Immunol. 2009
PubMed ID: 19380781
Functional polymorphism of CTLA-4 and ICOS genes in allogeneic hematopoietic stem cell transplantation.
Wu J, Tang JL, Wu SJ, Lio HY, Yang YC
Clin Chim Acta. 2009
PubMed ID: 19332044
Analyses of associations with asthma in four asthma population samples from Canada and Australia.
Daley D, Lemire M, Akhabir L, Chan-Yeung M, He JQ, McDonald T, Sandford A, Stefanowicz D, Tripp B, Zamar D, Bosse Y, Ferretti V, Montpetit A, Tessier MC, Becker A, Kozyrskyj AL, Beilby J, McCaskie PA, Musk B, Warrington N, James A, Laprise C, Palmer LJ, Paré PD, Hudson TJ
Hum Genet. 2009
PubMed ID: 19247692
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells.
Liu Y, Yu Y, Yang S, Zeng B, Zhang Z, Jiao G, Zhang Y, Cai L, Yang R
Cancer Immunol Immunother. 2009
PubMed ID: 18828017
CTLA4 gene polymorphisms are associated with chronic bronchitis.
Zhu G, Agusti A, Gulsvik A, Bakke P, ICGN investigators, Coxson H, Lomas DA, Silverman EK, Pillai SG
Eur Respir J. 2009
PubMed ID: 19386687
Synergistic inhibition of T-cell activation by a cell-permeable ZAP-70 mutant and ctCTLA-4.
Kim KD, Choi JM, Chae WJ, Lee SK
Biochem Biophys Res Commun. 2009
PubMed ID: 19230824
CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.
Kurtz J, Raval F, Vallot C, Der J, Sykes M
Blood. 2009
PubMed ID: 19179471
CTLA4 silencing with siRNA promotes deviation of Th1/Th2 in chronic hepatitis B patients.
Yu Y, Wu H, Tang Z, Zang G
Cell Mol Immunol. 2009
PubMed ID: 19403062
CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population.
Walker EJ, Hirschfield GM, Xu C, Lu Y, Liu X, Lu Y, Coltescu C, Wang K, Newman WG, Bykerk V, Keystone EC, Mosher D, Amos CI, Heathcote EJ, Siminovitch KA
Arthritis Rheum. 2009
PubMed ID: 19333938
The association of CTLA-4 and CD28 gene polymorphisms with idiopathic ischemic stroke in the paediatric population.
Wang JJ, Jiang LQ, He B, Shi KL, Li JW, Zou LP
Int J Immunogenet. 2009
PubMed ID: 19284445
Cytotoxic T lymphocyte-associated molecule-4 polymorphism in Turkish patients with Hashimoto thyroiditis.
Sahin M, Gursoy A, Erdogan MF
Int J Immunogenet. 2009
PubMed ID: 19284444
Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
Zee RY, Bubes V, Shrivastava S, Ridker PM, Glynn RJ
Clin Chim Acta. 2009
PubMed ID: 19263529
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
Pediatr Infect Dis J. 2009
PubMed ID: 19258923
Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.
Verhagen J, Gabrysová L, Minaee S, Sabatos CA, Anderson G, Sharpe AH, Wraith DC
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19218450
CTLA-4 +49A/G polymorphism is associated with Behçet's disease in a Tunisian population.
Ben Dhifallah I, Chelbi H, Braham A, Hamzaoui K, Houman MH
Tissue Antigens. 2009
PubMed ID: 19254250
CD152 (CTLA-4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin.
Hegel JK, Knieke K, Kolar P, Reiner SL, Brunner-Weinzierl MC
Eur J Immunol. 2009
PubMed ID: 19224637
A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
Wang X, Cheng S, Brophy VH, Erlich HA, Mannhalter C, Berger K, Lalouschek W, Browner WS, Shi Y, Ringelstein EB, Kessler C, Luedemann J, Lindpaintner K, Liu L, Ridker PM, Zee RY, Cook NR, RMS Stroke SNP Consortium
Stroke. 2009
PubMed ID: 19131662
Association between IL4 (-590), ACE (I)/(D), CCR5 (Delta32), CTLA4 (+49) and IL1-RN (VNTR in intron 2) gene polymorphisms and vitiligo.
Pehlivan S, Ozkinay F, Alper S, Onay H, Yuksel E, Pehlivan M, Ozkinay C
Eur J Dermatol. 2009
PubMed ID: 19129082
CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in first complete remission after induction chemotherapy.
Pérez-García A, Brunet S, Berlanga JJ, Tormo M, Nomdedeu J, Guardia R, Ribera JM, Heras I, Llorente A, Hoyos M, Esteve J, Besalduch J, Bueno J, Sierra J, Gallardo D, Grupo cooperativo para el estudio y tratamiento de las leucemias agudas
Leukemia. 2009
PubMed ID: 19092854
The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency.
Haimila K, Einarsdottir E, de Kauwe A, Koskinen LL, Pan-Hammarström Q, Kaartinen T, Kurppa K, Ziberna F, Not T, Vatta S, Ventura A, Korponay-Szabo IR, Adány R, Pocsai Z, Széles G, Dukes E, Kaukinen K, Mäki M, Koskinen S, Partanen J, Hammarström L, Saavalainen P
Genes Immun. 2009
PubMed ID: 19020530
The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats.
Huang LF, Yao YM, Zhang LT, Dong N, Yu Y, Sheng ZY
Shock. 2009
PubMed ID: 18665051
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.
Friedline RH, Brown DS, Nguyen H, Kornfeld H, Lee J, Zhang Y, Appleby M, Der SD, Kang J, Chambers CA
J Exp Med. 2009
PubMed ID: 19188497
Association of genetic variation in inducible costimulator gene with outcome of kidney transplantation.
Haimila K, Turpeinen H, Alakulppi NS, Kyllönen LE, Salmela KT, Partanen J
Transplantation. 2009
PubMed ID: 19202444
A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis.
Benson M, Mobini R, Barrenäs F, Halldén C, Naluai AT, Säll T, Cardell LO
Allergy. 2009
PubMed ID: 19222422
Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.
Velez DR, Fortunato S, Thorsen P, Lombardi SJ, Williams SM, Menon R
Am J Obstet Gynecol. 2009
PubMed ID: 19019335
Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGF beta gene variants.
Barreto M, Ferreira RC, Lourenco L, Moraes-Fontes MF, Santos E, Alves M, Carvalho C, Martins B, Andreia R, Viana JF, Vasconcelos C, Mota-Vieira L, Ferreira C, Demengeot J, Vicente AM
BMC Immunol. 2009
PubMed ID: 19173720
CTLA4 and Generalized Vitiligo: Two Genetic Association Studies and a Meta-Analysis of Published Data.
Birlea SA, Laberge GS, Procopciuc LM, Fain PR, Spritz RA
Pigment Cell Melanoma Res. 2009
PubMed ID: 19175525
[Susceptibility genetic variants in Hungarian morbus Crohn and ulcerative colitis patients]
Magyari L, Melegh B
Orv Hetil. 2009
PubMed ID: 19103559
TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells.
Elrefaei M, Burke CM, Baker CA, Jones NG, Bousheri S, Bangsberg DR, Cao H
PLoS One. 2009
PubMed ID: 20016783
[Genetic predisposition to multiple sclerosis as a polygenic autoimmune disease]
Favorova OO, Favorov AV, Boĭko AN, Sudomoina MA, Andreevskiĭ TV, Alekseenkov AD, Kulakova OG, Gusev EI, Parmigiani G, Ochs MF
Zh Nevrol Psikhiatr Im S S Korsakova. 2009
PubMed ID: 19894308
CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population.
Thye T, Scarisbrick G, Browne EN, Chinbuah MA, Gyapong J, Osei I, Owusu-Dabo E, Niemann S, Rüsch-Gerdes S, Meyer CG, Horstmann RD
PLoS One. 2009
PubMed ID: 19609446
Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity.
Toussirot E, Saas P, Deschamps M, Pouthier F, Perrot L, Perruche S, Chabod J, Tiberghien P, Wendling D
Arthritis Res Ther. 2009
PubMed ID: 19570209
If Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.
Menon R, Pearce B, Velez DR, Merialdi M, Williams SM, Fortunato SJ, Thorsen P
Reprod Biol Endocrinol. 2009
PubMed ID: 19527514
CD152 (CTLA-4) determines CD4 T cell migration in vitro and in vivo.
Knieke K, Hoff H, Maszyna F, Kolar P, Schrage A, Hamann A, Debes GF, Brunner-Weinzierl MC
PLoS One. 2009
PubMed ID: 19479036
PDCD1, CTLA-4 and p53 gene polymorphism and susceptibility to gestational trophoblastic diseases.
Dehaghani AS, Kashef MA, Ghaemenia M, Sarraf Z, Khaghanzadeh N, Fattahi MJ, Ghaderi A
J Reprod Med. 2009
PubMed ID: 19263877
Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort.
Martin TM, Bye L, Modi N, Stanford MR, Vaughan R, Smith JR, Wade NK, Mackensen F, Suhler EB, Rosenbaum JT, Wallace GR
Mol Vis. 2009
PubMed ID: 19180256
CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice.
Kolar P, Knieke K, Hegel JK, Quandt D, Burmester GR, Hoff H, Brunner-Weinzierl MC
Arthritis Rheum. 2009
PubMed ID: 19116935
Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay.
Greisenegger S, Zehetmayer S, Bauer P, Endler G, Ferrari J, Lang W, Janisiw M, Steiner L, Cheng S, Lalouschek W, Mannhalter C
Clin Chem. 2009
PubMed ID: 19028820
Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer.
Wang SS, Bratti MC, Rodríguez AC, Herrero R, Burk RD, Porras C, González P, Sherman ME, Wacholder S, Lan ZE, Schiffman M, Chanock SJ, Hildesheim A
J Infect Dis. 2009
PubMed ID: 19012493
CTLA4 targeting strategy in DNA vaccination against periodontitis.
Yu F, Xu QA, Sun G, Chen W
Med Hypotheses. 2009
PubMed ID: 18783892
Cytotoxic T lymphocyte antigen-4 promoter -658CT gene polymorphism is associated with ulcerative colitis in Chinese patients.
Luo Y, Xia B, Li C, Chen Z, Ge L, Jiang T, Zhou F, Zhao Y
Int J Colorectal Dis. 2008
PubMed ID: 19089435
Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis.
Choi JM, Kim SH, Shin JH, Gibson T, Yoon BS, Lee DH, Lee SK, Bothwell AL, Lim JS, Lee SK
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19066215
Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis.
Flores-Borja F, Jury EC, Mauri C, Ehrenstein MR
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19036923
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
Cooper JD, Smyth DJ, Smiles AM, Plagnol V, Walker NM, Allen JE, Downes K, Barrett JC, Healy BC, Mychaleckyj JC, Warram JH, Todd JA
Nat Genet. 2008
PubMed ID: 18978792
Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis.
Watanabe K, Rao VP, Poutahidis T, Rickman BH, Ohtani M, Xu S, Rogers AB, Ge Z, Horwitz BH, Fujioka T, Erdman SE, Fox JG
Infect Immun. 2008
PubMed ID: 18824539
CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors.
Shah KV, Chien AJ, Yee C, Moon RT
J Invest Dermatol. 2008
PubMed ID: 18563180
Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cells.
Jarvis LB, Goodall JC, Gaston JS
Hum Immunol. 2008
PubMed ID: 18817831
Effects of inhaled fluticasone propionate on CTLA-4-positive CD4+CD25+ cells in induced sputum in mild asthmatics.
Kawayama T, Kinoshita T, Imaoka H, Gauvreau GM, O'Byrne PM, Aizawa H
Respirology. 2008
PubMed ID: 18699801
Influence of the TSH Receptor Gene on Susceptibility to Graves' Disease and Graves' Ophthalmopathy.
Yin X, Latif R, Bahn R, Tomer Y, Davies TF
Thyroid. 2008
PubMed ID: 18925838
A common CTLA4 polymorphism confers susceptibility to Autoimmune Thyroid Disease in celiac children.
Tolone C, Cirillo G, Papparella A, Tolone S, Santoro N, Grandone A, Perrone L, Del Giudice EM
Dig Liver Dis. 2008
PubMed ID: 18929517
CTLA-4 control over Foxp3+ regulatory T cell function.
Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S
Science. 2008
PubMed ID: 18845758
[Expressions of Fas, CTLA-4 and RhoBTB2 genes in breast carcinoma and their relationship with clinicopathological factors]
Bi Y, Wei L, Mao HT, Zhang L, Zuo WS
Zhonghua Zhong Liu Za Zhi. 2008
PubMed ID: 19173804
Genetic factors of susceptibility and of severity in primary biliary cirrhosis.
Poupon R, Ping C, Chrétien Y, Corpechot C, Chazouillères O, Simon T, Heath SC, Matsuda F, Poupon RE, Housset C, Barbu V
J Hepatol. 2008
PubMed ID: 18930330
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
Habermann TM, Wang SS, Maurer MJ, Morton LM, Lynch CF, Ansell SM, Hartge P, Severson RK, Rothman N, Davis S, Geyer SM, Cozen W, Chanock SJ, Cerhan JR
Blood. 2008
PubMed ID: 18633131
CTLA-4 single-nucleotide polymorphisms in a Caucasian population with schizophrenia.
Jones AL, Holliday EG, Mowry BJ, McLean DE, McGrath JJ, Pender MP, Greer JM
Brain Behav Immun. 2008
PubMed ID: 18848621
Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer.
Sun T, Zhou Y, Yang M, Hu Z, Tan W, Han X, Shi Y, Yao J, Guo Y, Yu D, Tian T, Zhou X, Shen H, Lin D
Cancer Res. 2008
PubMed ID: 18757416
CTLA4 gene polymorphisms in children and adolescents with autoimmune thyroid diseases.
Yeşilkaya E, Koç A, Bideci A, Camurdan O, Boyraz M, Erkal O, Ergun MA, Cinaz P
Genet Test. 2008
PubMed ID: 18752454
Anergy in memory CD4+ T cells is induced by B cells.
Dalai SK, Mirshahidi S, Morrot A, Zavala F, Sadegh-Nasseri S
J Immunol. 2008
PubMed ID: 18713993
CTLA-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNS.
Hodi FS, Oble DA, Drappatz J, Velazquez EF, Ramaiya N, Ramakrishna N, Day AL, Kruse A, Mac Rae S, Hoos A, Mihm M
Nat Clin Pract Oncol. 2008
PubMed ID: 18665147
Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis.
Gu M, Kakoulidou M, Giscombe R, Pirskanen R, Lefvert AK, Klareskog L, Wang X
Clin Immunol. 2008
PubMed ID: 18595775
TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells.
Catalfamo M, Tai X, Karpova T, McNally J, Henkart PA
Immunology. 2008
PubMed ID: 18397268
CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion.
Kavanagh B, O'Brien S, Lee D, Hou Y, Weinberg V, Rini B, Allison JP, Small EJ, Fong L
Blood. 2008
PubMed ID: 18523152
Genomic regulation of CTLA4 and Multiple Sclerosis.
Palacios R, Comas D, Elorza J, Villoslada P
J Neuroimmunol. 2008
PubMed ID: 18691768
Cytotoxic T lymphocyte associated antigen-4 exon 1 A/G polymorphism in Iranian patients with multiple sclerosis.
Borhani Haghighi A, Ghahramani S, Azarpira N, Pourjafar M, Nikseresht AR
Eur J Neurol. 2008
PubMed ID: 18705023
Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children.
Chan IH, Tang NL, Leung TF, Huang W, Lam YY, Li CY, Wong CK, Wong GW, Lam CW
Allergy. 2008
PubMed ID: 18691306
[Association of polymorphism of proteintyrosine phosphatase nonreceptor-22 gene with AITD.]
Yu ZY, Zhang JA, Maier HB, Wang Y, Xiao WX, Quan Y, Dong BN
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008
PubMed ID: 18687223
Investigation of CTLA-4 and CD28 gene polymorphisms in a group of Turkish patients with colorectal cancer.
Dilmec F, Ozgonul A, Uzunkoy A, Akkafa F
Int J Immunogenet. 2008
PubMed ID: 18680513
CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis.
Tang AL, Teijaro JR, Njau MN, Chandran SS, Azimzadeh A, Nadler SG, Rothstein DM, Farber DL
J Immunol. 2008
PubMed ID: 18641318
Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.
Zheng Y, Manzotti CN, Burke F, Dussably L, Qureshi O, Walker LS, Sansom DM
J Immunol. 2008
PubMed ID: 18641304
Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis.
Oble DA, Mino-Kenudson M, Goldsmith J, Hodi FS, Seliem RM, Dranoff G, Mihm M, Hasserjian R, Lauwers GY
Am J Surg Pathol. 2008
PubMed ID: 18545145
Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.
Onishi Y, Fehervari Z, Yamaguchi T, Sakaguchi S
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18635688
Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas.
Bonzheim I, Geissinger E, Chuang WY, Roth S, Ströbel P, Marx A, Reimer P, Wilhelm M, Puppe B, Rosenwald A, Müller-Hermelink HK, Rüdiger T
J Hematop. 2008
PubMed ID: 19669200
CTLA-4 gene variants are not associated with Behçet's disease or its clinical manifestations.
Touma Z, Hamdan A, Shamseddeen W, Nasr J, Makhoul N, Zalloua PA, Arayssi T
Clin Exp Rheumatol. 2008
PubMed ID: 19026137
Association of CT60 polymorphism of the CTLA4 gene with Graves' disease in Taiwanese children.
Tsai ST, Huang CY, Lo FS, Chang YT, Tanizawa T, Chen CK, Wang ZC, Liu HF, Chu CC, Lin M, Lin CH, Li HJ, Lee YJ
J Pediatr Endocrinol Metab. 2008
PubMed ID: 18780601
Primary Biliary Cirrhosis Is Associated With a Genetic Variant in the 3' Flanking Region of the CTLA4 Gene.
Juran BD, Atkinson EJ, Schlicht EM, Fridley BL, Lazaridis KN
Gastroenterology. 2008
PubMed ID: 18778710
[Effects of Tongbi Mixture 2 on expressions of CD28 and CD152 and content of tumor necrosis factor-alpha in peripheral blood in rats with collagen-induced arthritis]
Liu H, Liu QP, Chen JF, Huang YM, Xu Q, Li SG
Zhong Xi Yi Jie He Xue Bao. 2008
PubMed ID: 18601859
Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis.
Prahalad S, Bohnsack JF, Whiting A, Clifford B, Jorde LB, Guthery SL, Thompson SD, Glass DN, Bamshad MJ
Arthritis Rheum. 2008
PubMed ID: 18576317
Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity.
Stohl W, Jacob N, Quinn WJ, Cancro MP, Gao H, Putterman C, Gao X, Pricop L, Koss MN
J Immunol. 2008
PubMed ID: 18566449
Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade.
Breunis WB, Tarazona-Santos E, Chen R, Kiley M, Rosenberg SA, Chanock SJ
J Immunother. 2008
PubMed ID: 18528295
Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.
George JF, Braun A, Brusko TM, Joseph R, Bolisetty S, Wasserfall CH, Atkinson MA, Agarwal A, Kapturczak MH
Am J Pathol. 2008
PubMed ID: 18511516
Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese.
Umemura T, Ota M, Yoshizawa K, Katsuyama Y, Ichijo T, Tanaka E, Kiyosawa K
Hepatol Res. 2008
PubMed ID: 18371160
New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer.
Guzman VB, Yambartsev A, Goncalves-Primo A, Silva ID, Carvalho CR, Ribalta JC, Goulart LR, Shulzhenko N, Gerbase-Delima M, Morgun A
Hum Mol Genet. 2008
PubMed ID: 18337305
Immunological inhibition of transplanted liver allografts by adeno-associated virus vector encoding CTLA4Ig in rats.
Lu S, Yu Y, Gao Y, Li GQ, Wang XH
Hepatobiliary Pancreat Dis Int. 2008
PubMed ID: 18522879
CTLA-4 trafficking and surface expression.
Valk E, Rudd CE, Schneider H
Trends Immunol. 2008
PubMed ID: 18468488
Association of CTLA-4 and IL-13 Gene Polymorphisms with Graves' Disease and Ophthalmopathy in Chinese Children.
Chong KK, Chiang SW, Wong GW, Tam PO, Ng TK, Hu YJ, Yam GH, Lam DS, Pang CP
Invest Ophthalmol Vis Sci. 2008
PubMed ID: 18296657
CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients.
Botturi K, Lacoeuille Y, Thomas P, Boniface S, Reynaud-Gaubert M, Magnan A
Eur Respir J. 2008
PubMed ID: 18256061
CTLA-4 polymorphisms are not associated with ocular inflammatory disease.
Bye L, Modi N, Stanford MR, Kondeatis E, Vaughan R, Fortune F, Kanawati C, Ben-Chetrit E, Ghabra M, Murray PI, Wallace GR
Tissue Antigens. 2008
PubMed ID: 18498289
Graves' Disease in Brazilian Children and Adults: Lack of Genetic Association with CTLA-4 +49A>G Polymorphism.
Namo Cury A, Longui CA, Kochi C, Calliari LE, Scalissi N, Salles JE, Neves Rocha M, Barbosa de Melo M, Rezende Melo M, Monte O
Horm Res. 2008
PubMed ID: 18493148
Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking.
Costenbader KH, Chang SC, De Vivo I, Plenge R, Karlson EW
Arthritis Res Ther. 2008
PubMed ID: 18462498
CTLA-4 +49 A/G genotype and HLA-DRB1 polymorphisms in Turkish patients with Henoch-Schönlein purpura.
Soylemezoglu O, Peru H, Gonen S, Cetinyurek A, Ozkaya O, Bakkaloğlu S, Buyan N, Hasanoglu E
Pediatr Nephrol. 2008
PubMed ID: 18449568
CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population.
Wray BN, Stankovich J, Whittock L, Dwyer T, Ponsonby AL, van der Mei IA, Taylor B, Dickinson J, Foote S, McMorran BJ
J Neuroimmunol. 2008
PubMed ID: 18378005
Immunoregulatory gene polymorphisms are associated with ANCA-related vasculitis.
Slot MC, Sokolowska MG, Savelkouls KG, Janssen RG, Damoiseaux JG, Cohen Tervaert JW
Clin Immunol. 2008
PubMed ID: 18448390
Association of the CTLA-4 gene with Vogt-Koyanagi-Harada syndrome.
Du L, Yang P, Hou S, Lin X, Zhou H, Huang X, Wang L, Kijlstra A
Clin Immunol. 2008
PubMed ID: 18282809
Regulation of CD28 expression on CD8+ T cells by CTLA-4.
Berg M, Zavazava N
J Leukoc Biol. 2008
PubMed ID: 18162511
Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population.
Suwalska K, Pawlak E, Karabon L, Tomkiewicz A, Dobosz T, Urbaniak-Kujda D, Kuliczkowski K, Wolowiec D, Jedynak A, Frydecka I
Hum Immunol. 2008
PubMed ID: 18396212
Association of autoimmune pancreatitis with cytotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients.
Umemura T, Ota M, Hamano H, Katsuyama Y, Muraki T, Arakura N, Kawa S, Kiyosawa K
Am J Gastroenterol. 2008
PubMed ID: 18341485
[Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms with susceptibility to breast cancer.]
Li H, Fu ZK, Wang LH, Li DL, Wu N, Zhang J, Li DJ
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008
PubMed ID: 18328194
CTLA-4 CT60 polymorphism is not an independent genetic risk marker of rheumatoid arthritis in a Japanese population.
Tsukahara S, Iwamoto T, Ikari K, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N, Momohara S
Ann Rheum Dis. 2008
PubMed ID: 18292106
Frequency of concurrent autoimmune disorders in patients with autoimmune hepatitis: effect of age, gender, and genetic background.
Bittencourt PL, Farias AQ, Porta G, Cançado EL, Miura I, Pugliese R, Kalil J, Goldberg AC, Carrilho FJ
J Clin Gastroenterol. 2008
PubMed ID: 18223493
Increased frequency of the CTLA-4 49 A/G polymorphism in patients with acquired haemophilia A compared to healthy controls.
Pavlova A, Diaz-Lacava A, Zeitler H, Satoguina J, Niemann B, Krause M, Scharrer I, Hoerauf A, Wienker T, Oldenburg J
Haemophilia. 2008
PubMed ID: 18081831
Family-based association study of cytotoxic T-lymphocyte antigen-4 with susceptibility to Graves' disease in Han population of Taiwan.
Chen PL, Fann CS, Chang CC, Wu IL, Chiu WY, Lin CY, Yang WS, Chang TC
Genes Immun. 2008
PubMed ID: 18059468
Immunomodulatory and osteogenic differentiation effects of mesenchymal stem cells by adenovirus-mediated coexpression of CTLA4Ig and BMP2.
Zhang X, Zhang C, Tang T, Qu Z, Lou J, Dai K
J Orthop Res. 2008
PubMed ID: 17960657
Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: no association in patients from Germany, Hungary and Poland.
Greve B, Simonenko R, Illes Z, Peterfalvi A, Hamdi N, Mycko MP, Selmaj KW, Rozsa C, Rajczy K, Bauer P, Berger K, Weissert R
Mult Scler. 2008
PubMed ID: 17942509
Polymorphism of the oestrogen receptor beta gene (ESR2) is associated with susceptibility to Graves' disease.
Kisiel B, Bednarczuk T, Kostrzewa G, Kosińska J, Miśkiewicz P, Płazińska MT, Bar-Andziak E, Królicki L, Krajewski P, Płoski R
Clin Endocrinol (Oxf). 2008
PubMed ID: 17941906
Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study.
Karlson EW, Chibnik LB, Cui J, Plenge RM, Glass RJ, Maher NE, Parker A, Roubenoff R, Izmailova E, Coblyn JS, Weinblatt ME, Shadick NA
Ann Rheum Dis. 2008
PubMed ID: 17666451
Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis.
Garrido P, Almeida J, Romero JM, Cantón J, Sandberg Y, Bárcena P, Lima M, Langerak AW, Orfao A, Ruiz-Cabello F
Hum Immunol. 2008
PubMed ID: 18361934
Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T
Rheumatology (Oxford). 2008
PubMed ID: 18174230
IL-27 inhibits the development of regulatory T cells via STAT3.
Huber M, Steinwald V, Guralnik A, Brüstle A, Kleemann P, Rosenplänter C, Decker T, Lohoff M
Int Immunol. 2008
PubMed ID: 18156621
Distribution of the CTLA-4 single nucleotide polymorphisms CT60G>A and +49A>G in psoriasis vulgaris patients and control individuals from a Polish Caucasian population.
Łuszczek W, Majorczyk E, Nockowski P, Pluciński P, Jasek M, Nowak I, Wiśniewski A, Kuśnierczyk P
Int J Immunogenet. 2008
PubMed ID: 18093182
Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis.
Juran BD, Atkinson EJ, Schlicht EM, Fridley BL, Petersen GM, Lazaridis KN
Hepatology. 2008
PubMed ID: 18041714
PTPN22 Is Genetically Associated with Risk of Generalized Vitiligo, but CTLA4 Is Not.
Laberge GS, Bennett DC, Fain PR, Spritz RA
J Invest Dermatol. 2008
PubMed ID: 18200060
Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms.
Berry A, Tector M, Oaks MK
J Negat Results Biomed. 2008
PubMed ID: 19014504
Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis.
Atik B, Skwor TA, Kandel RP, Sharma B, Adhikari HK, Steiner L, Erlich H, Dean D
PLoS ONE. 2008
PubMed ID: 18974840
Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
Velez DR, Fortunato SJ, Thorsen P, Lombardi SJ, Williams SM, Menon R
PLoS ONE. 2008
PubMed ID: 18818748
Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
Skibola CF, Bracci PM, Halperin E, Nieters A, Hubbard A, Paynter RA, Skibola DR, Agana L, Becker N, Tressler P, Forrest MS, Sankararaman S, Conde L, Holly EA, Smith MT
PLoS ONE. 2008
PubMed ID: 18636124
CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization.
Schneider H, Smith X, Liu H, Bismuth G, Rudd CE
Eur J Immunol. 2008
PubMed ID: 18095376
Two SNPs in the promoter region of the CTLA-4 gene affect binding of transcription factors and are associated with human myasthenia gravis.
Wang XB, Pirskanen R, Giscombe R, Lefvert AK
J Intern Med. 2008
PubMed ID: 18088253
The 3' UTR of the human CTLA4 mRNA can regulate mRNA stability and translational efficiency.
Malquori L, Carsetti L, Ruberti G
Biochim Biophys Acta. 2008
PubMed ID: 18078835
CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women.
Jääskeläinen E, Toivonen S, Keski-Nisula L, Paattiniemi EL, Helisalmi S, Punnonen K, Heinonen S
Clin Chem Lab Med. 2008
PubMed ID: 18076363
CT60 A/G marker of the 3'-UTR of the CTLA4 gene and liver transplant.
Muro M, Rojas G, Botella C, Miras M, Campillo JA, Minguela A, Sánchez-Bueno F, Bermejo J, Ramírez P, Alvarez-López MR
Transpl Immunol. 2008
PubMed ID: 18047932
Adult T-cell leukemia/lymphoma cells from blood and skin tumors express cytotoxic T lymphocyte-associated antigen-4 and Foxp3 but lack suppressor activity toward autologous CD8+ T cells.
Shimauchi T, Kabashima K, Tokura Y
Cancer Sci. 2008
PubMed ID: 17970785
Donor CTLA-4 +49 A/G*GG genotype is associated with chronic GVHD after HLA-identical haematopoietic stem-cell transplantations.
Azarian M, Busson M, Lepage V, Charron D, Toubert A, Loiseau P, de Latour RP, Rocha V, Socié G
Blood. 2007
PubMed ID: 18056853
CTLA-4 gene promoter and exon 1 polymorphisms in Iranian patients with gastric and colorectal cancers.
Hadinia A, Hossieni SV, Erfani N, Saberi-Firozi M, Fattahi MJ, Ghaderi A
J Gastroenterol Hepatol. 2007
PubMed ID: 18031393
A new role of CTLA-4 on B cells in thymus-dependent immune responses in vivo.
Quandt D, Hoff H, Rudolph M, Fillatreau S, Brunner-Weinzierl MC
J Immunol. 2007
PubMed ID: 18025174
Susceptible alleles of the CD40 and CTLA-4 genes are not associated with the relapse after antithyroid withdrawal in Graves' disease.
Kim KW, Park YJ, Kim TY, Park do J, Park KS, Cho BY
Thyroid. 2007
PubMed ID: 17949264
Allelic variant in CTLA4 alters T cell phosphorylation patterns.
Maier LM, Anderson DE, De Jager PL, Wicker LS, Hafler DA
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18000051
Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease.
Schott E, Witt H, Pascu M, van Boemmel F, Weich V, Bergk A, Halangk J, Müller T, Puhl G, Wiedenmann B, Berg T
Eur J Gastroenterol Hepatol. 2007
PubMed ID: 18049163
Possible association of CTLA-4 gene polymorphism with cyclosporine-induced gingival overgrowth in kidney transplant recipients.
Kusztal M, Radwan-Oczko M, Kościelska-Kasprzak K, Boratyńska M, Patrzałek D, Klinger M
Transplant Proc. 2007
PubMed ID: 18021981
Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations.
Lan Q, Shen M, Garcia-Rossi D, Chanock S, Zheng T, Berndt SI, Puri V, Li G, He X, Welch R, Zahm SH, Zhang L, Zhang Y, Smith M, Wang SS, Chiu BC, Linet M, Hayes R, Rothman N, Yeager M
Immunogenetics. 2007
PubMed ID: 17938902
Genetic analysis of the exon 1 position 49 CD152 dimorphism in multiple sclerosis.
Stuart R, Lovett-Racke AE, Frohman EM, Hawker K, Racke MK
J Neuroimmunol. 2007
PubMed ID: 17920697
Recipient cytotoxic T lymphocyte antigen-4 +49 G/G genotype is associated with reduced incidence of hepatitis B virus recurrence after liver transplantation among Chinese patients.
Jiang Z, Feng X, Zhang W, Gao F, Ling Q, Zhou L, Xie H, Chen Q, Zheng S
Liver Int. 2007
PubMed ID: 17919231
Significance of CTLA-4 and CD14 genetic polymorphisms in clinical outcome after allogeneic stem cell transplantation.
Vannucchi AM, Guidi S, Guglielmelli P, Glinz S, Lombardini L, Busca A, Locatelli F, Dall'Omo AM, Bosi A
Bone Marrow Transplant. 2007
PubMed ID: 17846597
Transforming growth factor beta-producing Foxp3(+)CD8(+)CD25(+) T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions.
Sugita S, Futagami Y, Horie S, Mochizuki M
Exp Eye Res. 2007
PubMed ID: 17720157
Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25- TGF-beta 1+ adaptive regulatory T cells.
Li R, Perez N, Karumuthil-Melethil S, Prabhakar BS, Holterman MJ, Vasu C
J Immunol. 2007
PubMed ID: 17911604
Diminished myelin-specific T cell activation associated with increase in CTLA4 and Fas molecules in multiple sclerosis patients treated with IFN-beta.
Hallal-Longo DE, Mirandola SR, Oliveira EC, Farias AS, Pereira FG, Metze IL, Brandão CO, Ruocco HH, Damasceno BP, Santos LM
J Interferon Cytokine Res. 2007
PubMed ID: 17970696
CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo.
Taylor MD, Harris A, Babayan SA, Bain O, Culshaw A, Allen JE, Maizels RM
J Immunol. 2007
PubMed ID: 17878360
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.
Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A
Nat Immunol. 2007
PubMed ID: 17873878
Genetic analyses of celiac disease in a Spanish population confirm association with CELIAC3 but not with CELIAC4.
Capilla A, Donat E, Planelles D, Espinós C, Ribes-Koninckx C, Palau F
Tissue Antigens. 2007
PubMed ID: 17767555
ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia.
Joshi AD, Hegde GV, Dickinson JD, Mittal AK, Lynch JC, Eudy JD, Armitage JO, Bierman PJ, Bociek RG, Devetten MP, Vose JM, Joshi SS
Clin Cancer Res. 2007
PubMed ID: 17875758
CD45RB ligation inhibits allergic pulmonary inflammation by inducing CTLA4 transcription.
Jen KY, Campo M, He H, Makani SS, Velasco G, Rothstein DM, Perkins DL, Finn PW
J Immunol. 2007
PubMed ID: 17785861
Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter.
Gibson HM, Hedgcock CJ, Aufiero BM, Wilson AJ, Hafner MS, Tsokos GC, Wong HK
J Immunol. 2007
PubMed ID: 17785820
Molecular determinants of inverse agonist activity of biologicals targeting CTLA-4.
Teft WA, Madrenas J
J Immunol. 2007
PubMed ID: 17785798
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
J Infect Dis. 2007
PubMed ID: 17703412
[Role of CD28/CTLA-4 co-stimulators in immune pathophysiology of aplastic anemia]
He GS, Zhou L, Wu DP, Sun AN, Miao M, Wang XL, Chang WR, Zhu ZL, Jin ZM, Qiu HY, Tang XW, Fu ZZ, Han Y, Ma X, Chen SN, Wu XJ
Zhonghua Xue Ye Xue Za Zhi. 2007
PubMed ID: 18246813
T-cell regulatory gene CTLA-4 polymorphism/haplotype association with autoimmune pancreatitis.
Chang MC, Chang YT, Tien YW, Liang PC, Jan IS, Wei SC, Wong JM
Clin Chem. 2007
PubMed ID: 17712006
Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.
Tai X, Van Laethem F, Sharpe AH, Singer A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17702861
CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes.
Love VA, Grabie N, Duramad P, Stavrakis G, Sharpe A, Lichtman A
Circ Res. 2007
PubMed ID: 17569889
High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer.
Cozar JM, Romero JM, Aptsiauri N, Vazquez F, Vilchez JR, Tallada M, Garrido F, Ruiz-Cabello F
Hum Immunol. 2007
PubMed ID: 17678726
Cytotoxic T lymphocyte antigen 4 gene polymorphism associated with ST-segment elevation acute myocardial infarction.
Yip HK, Wang PW, Chang LT, Youssef AA, Sheu JJ, Lee FY, Wu CJ
Circ J. 2007
PubMed ID: 17652883
Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis.
Kavvoura FK, Akamizu T, Awata T, Ban Y, Chistiakov DA, Frydecka I, Ghaderi A, Gough SC, Hiromatsu Y, Ploski R, Wang PW, Ban Y, Bednarczuk T, Chistiakova EI, Chojm M, Heward JM, Hiratani H, Juo SH, Karabon L, Katayama S, Kurihara S, Liu RT, Miyake I, Omrani GH, Pawlak E, Taniyama M, Tozaki T, Ioannidis JP
J Clin Endocrinol Metab. 2007
PubMed ID: 17504905
Foxp3+CD25+ T regulatory cells stimulate IFN-gamma-independent CD152-mediated activation of tryptophan catabolism that provides dendritic cells with immune regulatory activity in mice unresponsive to staphylococcal enterotoxin B.
Feunou P, Vanwetswinkel S, Gaudray F, Goldman M, Matthys P, Braun MY
J Immunol. 2007
PubMed ID: 17617582
CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase.
Wei B, da Rocha Dias S, Wang H, Rudd CE
J Immunol. 2007
PubMed ID: 17579061
CTLA4 gene polymorphisms and multiple sclerosis in Northern Ireland.
Heggarty S, Suppiah V, Silversides J, O'doherty C, Droogan A, McDonnell G, Hawkins S, Graham C, Vandenbroeck K
J Neuroimmunol. 2007
PubMed ID: 17524498
Susceptibility genes in Graves' ophthalmopathy: searching for a needle in a haystack?
Bednarczuk T, Gopinath B, Ploski R, Wall JR
Clin Endocrinol (Oxf). 2007
PubMed ID: 17521325
CTLA-4 blockade in murine bone marrow chimeras induces a host-derived antileukemic effect without graft-versus-host disease.
Fevery S, Billiau AD, Sprangers B, Rutgeerts O, Lenaerts C, Goebels J, Landuyt W, Kasran A, Boon L, Sagaert X, De Wolf-Peeters C, Waer M, Vandenberghe P
Leukemia. 2007
PubMed ID: 17508005
Association of -318 C/T and +49 A/G cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms with a clinical subset of Italian patients with systemic sclerosis.
Balbi G, Ferrera F, Rizzi M, Piccioli P, Morabito A, Cardamone L, Ghio M, Palmisano GL, Carrara P, Pedemonte S, Sessarego M, De Angioletti M, Notaro R, Indiveri F, Pistillo MP
Clin Exp Immunol. 2007
PubMed ID: 17459075
Cytotoxic T lymphocyte-associated molecule-4 gene polymorphism and hyperthyroid Graves' disease relapse after antithyroid drug withdrawal: a follow-up study.
Wang PW, Chen IY, Liu RT, Hsieh CJ, Hsi E, Juo SH
J Clin Endocrinol Metab. 2007
PubMed ID: 17426089
CTLA-4 polymorphisms and clinical outcome after allogeneic stem cell transplantation from HLA-identical sibling donors.
Pérez-García A, De la Cámara R, Román-Gómez J, Jiménez-Velasco A, Encuentra M, Nieto JB, de la Rubia J, Urbano-Ispizúa A, Brunet S, Iriondo A, González M, Serrano D, Espigado I, Solano C, Ribera JM, Pujal JM, Hoyos M, Gallardo D, GVHD/Immunotherapy Committee of the Spanish Group of Hematopoietic Stem Cell Transplantation
Blood. 2007
PubMed ID: 17384200
Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice.
Walsh CM, Smith P, Fallon PG
Parasite Immunol. 2007
PubMed ID: 17518948
The CD28/CTLA-4-B7 signaling pathway is involved in both allergic sensitization and tolerance induction to orally administered peanut proteins.
van Wijk F, Nierkens S, de Jong W, Wehrens EJ, Boon L, van Kooten P, Knippels LM, Pieters R
J Immunol. 2007
PubMed ID: 17513738
Cytotoxic T-lymphocyte-associated antigen-4 single nucleotide polymorphisms and haplotypes in primary biliary cirrhosis.
Donaldson P, Veeramani S, Baragiotta A, Floreani A, Venturi C, Pearce S, Wilson V, Jones D, James O, Taylor J, Newton J, Bassendine M
Clin Gastroenterol Hepatol. 2007
PubMed ID: 17482523
Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children.
Sohn MH, Kim SH, Song TW, Kim KW, Kim ES, Park HS, Kim KE
Pediatr Pulmonol. 2007
PubMed ID: 17469155
CTLA-4 gene and susceptibility to human papillomavirus-16-associated cervical squamous cell carcinoma in Taiwanese women.
Su TH, Chang TY, Lee YJ, Chen CK, Liu HF, Chu CC, Lin M, Wang PT, Huang WC, Chen TC, Yang YC
Carcinogenesis. 2007
PubMed ID: 17341658
The CTLA-4 -1661A/G and -1772T/C dimorphisms in Japanese patients with systemic sclerosis.
Takeuchi F, Nakaue N, Kawasugi K, Mori M, Kuwata S, Tanimoto K
Rheumatol Int. 2007
PubMed ID: 17225925
Interaction of maternal atopy, CTLA-4 gene polymorphism and gender on antenatal immunoglobulin E production.
Yang KD, Ou CY, Hsu TY, Chang JC, Chuang H, Liu CA, Liang HM, Kuo HC, Chen RF, Huang EY
Clin Exp Allergy. 2007
PubMed ID: 17456215
CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets.
Jackman RP, Balamuth F, Bottomly K
J Immunol. 2007
PubMed ID: 17442936
Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.
Chikuma S, Bluestone JA
Eur J Immunol. 2007
PubMed ID: 17429849
Pivotal advance: CTLA-4+ T cells exhibit normal antiviral functions during acute viral infection.
Raué HP, Slifka MK
J Leukoc Biol. 2007
PubMed ID: 17215523
No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples.
Magyari L, Faragó B, Bene J, Horvatovich K, Lakner L, Varga M, Figler M, Gasztonyi B, Mózsik G, Melegh B
World J Gastroenterol. 2007
PubMed ID: 17465502
[The implications of nasal associated lymphoid tissue in development of respiratory allergic diseases in children].
Zakrzewska A, Kobos J, Górski P
Med Wieku Rozwoj. 2007
PubMed ID: 17625281
No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: a meta-analysis.
Bagos PG, Karnaouri AC, Nikolopoulos GK, Hamodrakas SJ
Mult Scler. 2007
PubMed ID: 17439880
Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection.
Schott E, Witt H, Hinrichsen H, Neumann K, Weich V, Bergk A, Halangk J, Müller T, Tinjala S, Puhl G, Neuhaus P, Wiedenmann B, Berg T
J Hepatol. 2007
PubMed ID: 17150279
Human immunodeficiency virus (HIV) type 1 Vpr induces differential regulation of T cell costimulatory molecules: direct effect of Vpr on T cell activation and immune function.
Venkatachari NJ, Majumder B, Ayyavoo V
Virology. 2007
PubMed ID: 17023015
High IFN-gamma production of individual CD8 T lymphocytes is controlled by CD152 (CTLA-4).
Pandiyan P, Hegel JK, Krueger M, Quandt D, Brunner-Weinzierl MC
J Immunol. 2007
PubMed ID: 17277117
Analysis of CD28 and CTLA-4 gene polymorphisms in Turkish patients with Behcet's disease.
Gunesacar R, Erken E, Bozkurt B, Ozer HT, Dinkci S, Erken EG, Ozbalkan Z
Int J Immunogenet. 2007
PubMed ID: 17284227
Polymorphisms in the CTLA-4 gene and inhibitor development in patients with severe hemophilia A.
Astermark J, Wang X, Oldenburg J, Berntorp E, Lefvert AK, MIBS Study Group
J Thromb Haemost. 2007
PubMed ID: 17269936
B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells.
May KF, Chang X, Zhang H, Lute KD, Zhou P, Kocak E, Zheng P, Liu Y
J Immunol. 2007
PubMed ID: 17237403
Targeting of CD25 and glucocorticoid-induced TNF receptor family-related gene-expressing T cells differentially modulates asthma risk in offspring of asthmatic and normal mother mice.
Hubeau C, Apostolou I, Kobzik L
J Immunol. 2007
PubMed ID: 17237396
Production and characterization of human CTLA4Ig expressed in transgenic rice cell suspension cultures.
Lee SJ, Park CI, Park MY, Jung HS, Ryu WS, Lim SM, Tan HK, Kwon TH, Yang MS, Kim DI
Protein Expr Purif. 2007
PubMed ID: 17079164
Helicobacter pylori-induced indoleamine 2,3-dioxygenase activity in vivo is regulated by TGFB1 and CTLA4 polymorphisms.
Raitala A, Karjalainen J, Oja SS, Kosunen TU, Hurme M
Mol Immunol. 2007
PubMed ID: 16620985
Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.
Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17197413
Case-control association analysis of rheumatoid arthritis with candidate genes using related cases.
Yoo YJ, Gao G, Zhang K
BMC Proc. 2007
PubMed ID: 18466531
Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.
Mei L, Li X, Yang K, Cui J, Fang B, Guo X, Rotter JI
BMC Proc. 2007
PubMed ID: 18466513
Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population.
Wang L, Li D, Fu Z, Li H, Jiang W, Li D
BMC Cancer. 2007
PubMed ID: 17825114
Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus.
Lyssuk EY, Torgashina AV, Soloviev SK, Nassonov EL, Bykovskaia SN
Adv Exp Med Biol. 2007
PubMed ID: 17712998
CTLA-4 +49A/G and CT60 gene polymorphisms in primary Sjögren syndrome.
Gottenberg JE, Loiseau P, Azarian M, Chen C, Cagnard N, Hachulla E, Puechal X, Sibilia J, Charron D, Mariette X, Miceli-Richard C
Arthritis Res Ther. 2007
PubMed ID: 17341301
A suggestive association of fuchs heterochromic cyclitis with cytotoxic T cell antigen 4 gene polymorphism.
Spriewald BM, Lefter C, Huber I, Lauer B, Wenkel H
Ophthalmic Res. 2007
PubMed ID: 17287608
CTLA-4 gene exon-1 +49 A/G polymorphism: lack of association with autoimmune disease in patients with common variable immune deficiency.
Knight AK, Serrano D, Tomer Y, Cunningham-Rundles C
J Clin Immunol. 2007
PubMed ID: 17192819
The net effect of costimulatory blockers is dependent on the subset and activation status of the autoreactive T cells.
Zhang P, Sun D, Ke Y, Kaplan HJ, Shao H
J Immunol. 2007
PubMed ID: 17182586
The predictive value of CTLA-4 and Tg polymorphisms in the recurrence of Graves' disease after antithyroid withdrawal.
Tanrikulu S, Erbil Y, Ademoglu E, Işsever H, Barbaros U, Kutlutürk F, Ozarmagan S, Tezelman S
Endocrine. 2006
PubMed ID: 17526951
Possible association of cytotoxic T lymphocyte antigen-4 genetic polymorphism with liver damage of primary biliary cirrhosis in Japan.
Kanno Y, Rai T, Monoe K, Saito H, Takahashi A, Irisawa A, Ohira H
Fukushima J Med Sci. 2006
PubMed ID: 17427759
[Susceptibility genes for the development of autoimmune thyroid disease]
Shirasawa S
Nippon Rinsho. 2006
PubMed ID: 17154080
B7+ iris pigment epithelial cells convert T cells into CTLA-4+, B7-expressing CD8+ regulatory T cells.
Sugita S, Keino H, Futagami Y, Takase H, Mochizuki M, Stein-Streilein J, Streilein JW
Invest Ophthalmol Vis Sci. 2006
PubMed ID: 17122127
CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.
Gattinoni L, Ranganathan A, Surman DR, Palmer DC, Antony PA, Theoret MR, Heimann DM, Rosenberg SA, Restifo NP
Blood. 2006
PubMed ID: 16882704
TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression.
Bulwin GC, Heinemann T, Bugge V, Winter M, Lohan A, Schlawinsky M, Schulze A, Wälter S, Sabat R, Schülein R, Wiesner B, Veh RW, Löhler J, Blumberg RS, Volk HD, Utku N
J Immunol. 2006
PubMed ID: 17082597
Risk of adverse post-transplant events after kidney allograft transplantation as predicted by CTLA-4 +49 and TNF-alpha -308 single nucleotide polymorphisms: a preliminary study.
Gendzekhadze K, Rivas-Vetencourt P, Montano RF
Transpl Immunol. 2006
PubMed ID: 17138053
Association of Graves' disease and Graves' ophthalmopathy with the polymorphisms in promoter and exon 1 of cytotoxic T lymphocyte associated antigen-4 gene.
Zhang Q, Yang YM, Lv XY
J Zhejiang Univ Sci B. 2006
PubMed ID: 17048303
Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based study.
Graham DS, Wong AK, McHugh NJ, Whittaker JC, Vyse TJ
Hum Mol Genet. 2006
PubMed ID: 17000707
Induction of IL-10 suppressors in lung transplant patients by CD4+25+ regulatory T cells through CTLA-4 signaling.
Bharat A, Fields RC, Trulock EP, Patterson GA, Mohanakumar T
J Immunol. 2006
PubMed ID: 17015751
Differential roles of the co-stimulatory molecules GITR and CTLA-4 in the immune response to Trichinella spiralis.
Furze RC, Culley FJ, Selkirk ME
Microbes Infect. 2006
PubMed ID: 17045510
Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.
Zaunders JJ, Ip S, Munier ML, Kaufmann DE, Suzuki K, Brereton C, Sasson SC, Seddiki N, Koelsch K, Landay A, Grey P, Finlayson R, Kaldor J, Rosenberg ES, Walker BD, Fazekas de St Groth B, Cooper DA, Kelleher AD
J Virol. 2006
PubMed ID: 17005693
The influence of CTLA-4 gene polymorphisms on liver transplant outcomes.
Perkins JD
Liver Transpl. 2006
PubMed ID: 17004266
Reversal of the TCR stop signal by CTLA-4.
Schneider H, Downey J, Smith A, Zinselmeyer BH, Rush C, Brewer JM, Wei B, Hogg N, Garside P, Rudd CE
Science. 2006
PubMed ID: 16931720
Ctla-4 exon 1 (+49) and promoter (-318) gene polymorphisms in kidney transplantation.
Gorgi Y, Sfar I, Abdallah TB, Abderrahim E, Ayed SJ, Aouadi H, Bardi R, Ayed K
Transplant Proc. 2006
PubMed ID: 16980072
Polymorphism of the promoter region and exon 1 of the CTLA4 gene in endemic pemphigus foliaceus (fogo selvagem).
Pavoni DP, Cerqueira LB, Roxo VM, Petzl-Erler ML
Braz J Med Biol Res. 2006
PubMed ID: 16972006
TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling.
Oida T, Xu L, Weiner HL, Kitani A, Strober W
J Immunol. 2006
PubMed ID: 16887994
CTLA4 polymorphisms and ophthalmopathy in Graves' disease patients: association study and meta-analysis.
Han S, Zhang S, Zhang W, Li R, Li Y, Wang Z, Xie Y, Mao Y
Hum Immunol. 2006
PubMed ID: 16916658
The common -318C/T polymorphism in the promoter region of CTLA4 gene is associated with reduced risk of ophthalmopathy in Chinese Graves' patients.
Han SZ, Zhang SH, Li R, Zhang WY, Li Y
Int J Immunogenet. 2006
PubMed ID: 16893393
Influence of CTLA4 haplotypes on susceptibility and some extraglandular manifestations in primary Sjögren's syndrome.
Downie-Doyle S, Bayat N, Rischmueller M, Lester S
Arthritis Rheum. 2006
PubMed ID: 16869018
Cohort- and time-specific associations of CTLA4 genotypes with HIV-1 disease progression.
Shao W, Lazaryan A, Dorak MT, Penman-Aguilar A, Wilson CM, Margolick JB, Goedert JJ, Prins M, Tang J, Kaslow RA
AIDS. 2006
PubMed ID: 16868438
Migration and function of FoxP3+ regulatory T cells in the hematolymphoid system.
Kim CH
Exp Hematol. 2006
PubMed ID: 16863909
Association of polymorphisms in CTLA-4, IL-1ra and IL-1beta genes with multiple sclerosis in Serbian population.
Dincić E, Zivković M, Stanković A, Obradović D, Alavantić D, Kostić V, Raicević R
J Neuroimmunol. 2006
PubMed ID: 16769128
Association of T-cell regulatory gene polymorphisms with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma.
Cheng TY, Lin JT, Chen LT, Shun CT, Wang HP, Lin MT, Wang TE, Cheng AL, Wu MS
J Clin Oncol. 2006
PubMed ID: 16849765
CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism.
Engelhardt JJ, Sullivan TJ, Allison JP
J Immunol. 2006
PubMed ID: 16818761
Association of CTLA-4 gene promoter polymorphisms with systemic sclerosis in Iranian population.
Almasi S, Erfani N, Mojtahedi Z, Rajaee A, Ghaderi A
Genes Immun. 2006
PubMed ID: 16775619
[Cytotoxic T lymphocyte antigen-4 promoter gene polymorphism is significantly associated with ulcerative colitis]
Zhou F, Xia B, Guo QS, Wang Q, Li L, Jiang L, Cheng H
Zhonghua Nei Ke Za Zhi. 2006
PubMed ID: 16831326
Prolongation of renal allograft survival in rats by replication-defective recombinant adenovirus-mediated coexpression of CD40L and CTLA4Ig.
Tian PX, Li ZL, Zhang YS, Xue WJ, Wu J
Transplant Proc. 2006
PubMed ID: 16797372
High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice.
Behnke JM, Iraqi FA, Mugambi JM, Clifford S, Nagda S, Wakelin D, Kemp SJ, Baker RL, Gibson JP
Mamm Genome. 2006
PubMed ID: 16783640
Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression.
Oderup C, Cederbom L, Makowska A, Cilio CM, Ivars F
Immunology. 2006
PubMed ID: 16771859
[Study on association of CTLA4 gene polymorphism with Grave's disease in Guangxi Zhuang nationality population]
Liang XH, Qin YF, Ma Y, Xie XR, Xie KQ, Luo ZJ
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006
PubMed ID: 16767670
CTLA-4 gene polymorphisms and natural soluble CTLA-4 protein in psoriasis vulgaris.
Luszczek W, Kubicka W, Jasek M, Baran E, Cisło M, Nockowski P, Luczywo-Rudy M, Wiśniewski A, Nowak I, Kuśnierczyk P
Int J Immunogenet. 2006
PubMed ID: 16712655
Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.
Manzotti CN, Liu MK, Burke F, Dussably L, Zheng Y, Sansom DM
Eur J Immunol. 2006
PubMed ID: 16708397
Polymorphisms in the T cell regulatory gene cytotoxic T lymphocyte antigen 4 influence the rate of acute rejection after liver transplantation.
Tapirdamaz O, Pravica V, Metselaar HJ, Hansen B, Moons L, van Meurs JB, Hutchinson IV, Shaw J, Agarwal K, Adams DH, Day CP, Kwekkeboom J
Gut. 2006
PubMed ID: 16299026
Exon-1 polymorphism of ctla-4 gene is not associated with systemic sclerosis in Iranian patients.
Rajaee A, Ebrahimi A, Ghiam AF, Kalantari T, Ghaderi A
Rheumatol Int. 2006
PubMed ID: 16189655
Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease: the impact of DRB1*07.
Kula D, Bednarczuk T, Jurecka-Lubieniecka B, Polanska J, Hasse-Lazar K, Jarzab M, Steinhof-Radwanska K, Hejduk B, Zebracka J, Kurylowicz A, Bar-Andziak E, Stechly T, Pawlaczek A, Gubala E, Krawczyk A, Szpak-Ulczok S, Nauman J, Jarzab B
Thyroid. 2006
PubMed ID: 16756466
Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in Chinese patients.
Jiang Y, Xia B, Jiang L, Lv M, Guo Q, Chen M, Li J, Xia HH, Wong BC
Inflamm Bowel Dis. 2006
PubMed ID: 16670525
No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis.
Wiencke K, Boberg KM, Donaldson P, Harbo H, Ling V, Schrumpf E, Spurkland A
Scand J Gastroenterol. 2006
PubMed ID: 16638702
Induction of CTLA-4-mediated anergy contributes to persistent colonization in the murine model of gastric Helicobacter pylori infection.
Anderson KM, Czinn SJ, Redline RW, Blanchard TG
J Immunol. 2006
PubMed ID: 16621997
CTLA-4 engagement and regulatory CD4+CD25+ T cells independently control CD8+-mediated responses under costimulation blockade.
Coenen JJ, Koenen HJ, van Rijssen E, Boon L, Joosten I, Hilbrands LB
J Immunol. 2006
PubMed ID: 16621989
Expression of CD28 and cytotoxic T lymphocyte antigen 4 at the maternal-fetal interface in women with unexplained pregnancy loss.
Wang X, Ma Z, Hong Y, Lu P, Lin Q
Int J Gynaecol Obstet. 2006
PubMed ID: 16564528
Reduced function of CD4+25+ regulatory T cell fraction in silicosis patients.
Wu P, Miura Y, Hyodoh F, Nishimura Y, Hatayama T, Hatada S, Sakaguchi H, Kusaka M, Katsuyama H, Tomita M, Otsuki T
Int J Immunopathol Pharmacol. 2006
PubMed ID: 16831302
Thyroid autoantibody production is influenced by exon 1 and promoter CTLA-4 polymorphisms in patients with Hashimoto's thyroiditis.
Zaletel K, Krhin B, Gaberscek S, Hojker S
Int J Immunogenet. 2006
PubMed ID: 16611252
[The research on associating the single nucleotide polymorphism of CTLA-4 gene promoter region with idiopathic dilated cardiomyopathy]
Liu W, Li WM, Gao C, Li Y, Kong YH
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006
PubMed ID: 16604497
The CTLA4+49A/G and CT60 polymorphisms and chronic inflammatory arthropathies in Northern Ireland.
Suppiah V, O'Doherty C, Heggarty S, Patterson CC, Rooney M, Vandenbroeck K
Exp Mol Pathol. 2006
PubMed ID: 16248997
TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells.
Zheng SG, Wang JH, Stohl W, Kim KS, Gray JD, Horwitz DA
J Immunol. 2006
PubMed ID: 16517699
The genetic contribution of CTLA-4 dimorphisms in promoter and exon 1 regions in Japanese patients with rheumatoid arthritis.
Takeuchi F, Kawasugi K, Mori M, Nakaue N, Kobayashi N, Kuwata S, Murayama T, Matsuta K
Scand J Rheumatol. 2006
PubMed ID: 16641053
[A/G polymorphism at position 49 in exon 1 of CTLA-4 gene in Chinese women with unexplained recurrent spontaneous abortion]
Wang XP, Lin QD, Ma ZW, Hong Y, Zhao AM, Di W, Lu PH
Zhonghua Fu Chan Ke Za Zhi. 2006
PubMed ID: 16640877
Lack of a genetic association between the CTLA-4 gene and Graves' disease in Koreans.
Cho HJ, Chung JH, Kim IS, Kim HJ, Cho SH, Ki CS, Kim JW
Thyroid. 2006
PubMed ID: 16571085
Cytotoxic T lymphocyte antigen-4 promoter variants in breast cancer.
Erfani N, Razmkhah M, Talei AR, Pezeshki AM, Doroudchi M, Monabati A, Ghaderi A
Cancer Genet Cytogenet. 2006
PubMed ID: 16527605
No association between selected candidate gene polymorphisms and severe chronic periodontitis.
Wohlfahrt JC, Wu T, Hodges JS, Hinrichs JE, Michalowicz BS
J Periodontol. 2006
PubMed ID: 16512757
CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription.
Srahna M, Van Grunsven LA, Remacle JE, Vandenberghe P
Immunology. 2006
PubMed ID: 16476059
Polymorphisms within the CTLA4 gene are associated with infant atopic dermatitis.
Jones G, Wu S, Jang N, Fulcher D, Hogan P, Stewart G
Br J Dermatol. 2006
PubMed ID: 16445777
[CD28 and CTLA-4 costimulatory molecules expression on T lymphocytes and NK cells in nonallergic bronchial asthma].
Rutkowski R, Stasiak-Barmuta A, Moniuszko T, Rutkowska-Rogacz D, Woińska M, Rutkowski K, Sidorczuk M
Pol Merkur Lekarski. 2006
PubMed ID: 16708626
[Effects and mechanism of CD4+ CD25+ T cells on the airway inflammation of asthmatic mice].
Sun K, Lin KX, Wu K, Wang CZ
Zhonghua Jie He He Hu Xi Za Zhi. 2006
PubMed ID: 16677453
Analysis of cytotoxic T lymphocyte associated antigen 4 gene polymorphisms in patients with ulcerative colitis.
Lankarani KB, Karbasi A, Kalantari T, Yarmohammadi H, Saberi-Firoozi M, Alizadeh-Naeeni M, Taghavi AR, Fattahi MR, Ghaderi A
J Gastroenterol Hepatol. 2006
PubMed ID: 16509873
CTLA-4 lacking the cytoplasmic domain costimulates IL-2 production in T-cell hybridomas.
Hueber AJ, Matzkies FG, Rahmeh M, Manger B, Kalden JR, Nagel T
Immunol Cell Biol. 2006
PubMed ID: 16405652
Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to chronic hepatitis B.
Mohammad Alizadeh AH, Hajilooi M, Ranjbar M, Fallahian F, Mousavi SM
World J Gastroenterol. 2006
PubMed ID: 16489681
[The frequency of CTLA-4 gene polymorphism at position 49 exon 1 in children with Hashimoto's thyroiditis]
Kucharska A, Wiśniewska A, Rymkiewicz-Kluczyńska B
Endokrynol Diabetol Chor Przemiany Materii Wieku R. 2006
PubMed ID: 17020648
Distribution of CTLA-4 polymorphisms in allergic asthma.
Jasek M, Łuszczek W, Obojski A, Winiarska B, Hałubek K, Nowak I, Mańczak M, Wiśniewski A, Pawlik A, Jonkisz A, Lebioda A, Majorczyk E, Dobosz T, Kuśnierczyk P
Int Arch Allergy Immunol. 2006
PubMed ID: 16926542
Effects of cytotoxic T lymphocyte antigen 4 (CTLA4) signaling and locally applied steroid on retinal dysfunction by recoverin, cancer-associated retinopathy antigen.
Maeda A, Maeda T, Liang Y, Yenerel M, Saperstein DA
Mol Vis. 2006
PubMed ID: 16917481
Three allele combinations associated with multiple sclerosis.
Favorova OO, Favorov AV, Boiko AN, Andreewski TV, Sudomoina MA, Alekseenkov AD, Kulakova OG, Gusev EI, Parmigiani G, Ochs MF
BMC Med Genet. 2006
PubMed ID: 16872485
CTLA-4 regulation of T cell function via RAP-1-mediated adhesion.
Schneider H, Valk E, Dias Sda R, Wei B, Rudd CE
Adv Exp Med Biol. 2006
PubMed ID: 16802603
A comprehensive candidate gene study on bronchial asthma and juvenile idiopathic arthritis.
Schubert K, von Bonnsdorf H, Burke M, Ahlert I, Braun S, Berner R, Deichmann KA, Heinzmann A
Dis Markers. 2006
PubMed ID: 16788246
A molecular perspective of CTLA-4 function.
Teft WA, Kirchhof MG, Madrenas J
Annu Rev Immunol. 2006
PubMed ID: 16551244
Possible association of cytotoxic T-lymphocyte antigen 4 gene promoter single nucleotide polymorphism with acute rejection of allogeneic kidney transplant.
Wiśniewski A, Kusztal M, Magott-Procelewska M, Klinger M, Jasek M, Łuszczek W, Nowak I, Kosmaczewska A, Ciszak L, Frydecka I, Górski A, Kuśnierczyk P
Transplant Proc. 2006
PubMed ID: 16504663
Increased expression of CTLA-4 in malignant T-cells from patients with mycosis fungoides -- cutaneous T cell lymphoma.
Wong HK, Wilson AJ, Gibson HM, Hafner MS, Hedgcock CJ, Berger CL, Edelson RL, Lim HW
J Invest Dermatol. 2006
PubMed ID: 16417239
Association of CTLA-4 gene polymorphism with oral squamous cell carcinoma.
Wong YK, Chang KW, Cheng CY, Liu CJ
J Oral Pathol Med. 2006
PubMed ID: 16393254
B7+ iris pigment epithelium induce CD8+ T regulatory cells; both suppress CTLA-4+ T cells.
Sugita S, Ng TF, Lucas PJ, Gress RE, Streilein JW
J Immunol. 2006
PubMed ID: 16365402
Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population.
Brophy K, Ryan AW, Thornton JM, Abuzakouk M, Fitzgerald AP, McLoughlin RM, O'morain C, Kennedy NP, Stevens FM, Feighery C, Kelleher D, McManus R
Genes Immun. 2006
PubMed ID: 16237465
Immune response gene polymorphisms in renal transplant recipients.
Dmitrienko S, Hoar DI, Balshaw R, Keown PA
Transplantation. 2005
PubMed ID: 16378074
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
Plenge RM, Padyukov L, Remmers EF, Purcell S, Lee AT, Karlson EW, Wolfe F, Kastner DL, Alfredsson L, Altshuler D, Gregersen PK, Klareskog L, Rioux JD
Am J Hum Genet. 2005
PubMed ID: 16380915
[Relationship of CTLA-4 exon 1 A49-->G polymorphism with sCTLA-4 and Th1/Th2 bias in idiopathic dilated cardiomyopathy]
Liu W, Li WM, Gao C, Wang XR, Li DM, Sun NL
Zhonghua Yi Xue Za Zhi. 2005
PubMed ID: 16405845
Blockade of CTLA-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation tolerance.
Alenmyr L, Matheu V, Uller L, Greiff L, Malm-Erjefält M, Ljunggren HG, Persson CG, Korsgren M
Scand J Immunol. 2005
PubMed ID: 16305640
A function for interleukin 2 in Foxp3-expressing regulatory T cells.
Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY
Nat Immunol. 2005
PubMed ID: 16227984
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms.
Parry RV, Chemnitz JM, Frauwirth KA, Lanfranco AR, Braunstein I, Kobayashi SV, Linsley PS, Thompson CB, Riley JL
Mol Cell Biol. 2005
PubMed ID: 16227604
Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies.
Lute KD, May KF, Lu P, Zhang H, Kocak E, Mosinger B, Wolford C, Phillips G, Caligiuri MA, Zheng P, Liu Y
Blood. 2005
PubMed ID: 16037385
Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression.
Tan PH, Yates JB, Xue SA, Chan C, Jordan WJ, Harper JE, Watson MP, Dong R, Ritter MA, Lechler RI, Lombardi G, George AJ
Blood. 2005
PubMed ID: 15994283
HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity?
Brand O, Gough S, Heward J
Expert Rev Mol Med. 2005
PubMed ID: 16229750
Variants of the CTLA4 gene that segregate with autoimmune diseases are not associated with endometriosis.
Viganó P, Lattuada D, Somigliana E, Abbiati A, Candiani M, Di Blasio AM
Mol Hum Reprod. 2005
PubMed ID: 16373368
Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease.
Kurylowicz A, Kula D, Ploski R, Skorka A, Jurecka-Lubieniecka B, Zebracka J, Steinhof-Radwanska K, Hasse-Lazar K, Hiromatsu Y, Jarzab B, Bednarczuk T
Thyroid. 2005
PubMed ID: 16279844
A CTLA4high genotype is associated with myasthenia gravis in thymoma patients.
Chuang WY, Ströbel P, Gold R, Nix W, Schalke B, Kiefer R, Opitz A, Klinker E, Müller-Hermelink HK, Marx A
Ann Neurol. 2005
PubMed ID: 16178018
Virus attachment and replication are promoted after acquisition of host CD28 and CD152 by HIV-1.
Giguere JF, Diou J, Madrenas J, Tremblay MJ
J Infect Dis. 2005
PubMed ID: 16136471
Meta-analysis of the association of CTLA-4 exon-1 +49A/G polymorphism with rheumatoid arthritis.
Han S, Li Y, Mao Y, Xie Y
Hum Genet. 2005
PubMed ID: 16133179
Differential requirement for CD28/CTLA-4-CD80/CD86 interactions in drug-induced type 1 and type 2 immune responses to trinitrophenyl-ovalbumin.
Nierkens S, Aalbers M, Bol M, Bleumink R, van Kooten P, Boon L, Pieters R
J Immunol. 2005
PubMed ID: 16148116
CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function.
Schneider H, Valk E, da Rocha Dias S, Wei B, Rudd CE
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16126897
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Cytotoxic T lymphocyte antigen 4 polymorphism 49 (A>G) and migraine.
Lulli P, Trabace S, Morellini M, Cicciarelli G, Coloprisco G, Piane M, de Filippis S, Santi PG, Avramakou O, Ferlicca E, Martelletti P
J Headache Pain. 2005
PubMed ID: 16362660
Prevention of experimental autoimmune myocarditis by hydrodynamics-based naked plasmid DNA encoding CTLA4-Ig gene delivery.
Abe S, Hanawa H, Hayashi M, Yoshida T, Komura S, Watanabe R, Lie H, Chang H, Kato K, Kodama M, Maruyama H, Nakazawa M, Miyazaki J, Aizawa Y
J Card Fail. 2005
PubMed ID: 16198253
Cytotoxic T lymphocyte-associated molecule-4 polymorphisms in Turkish Graves' disease patients and association with probability of remission after antithyroid therapy.
Sahin M, Erdogan MF, Erdogan G
Eur J Intern Med. 2005
PubMed ID: 16137550
CTLA-4 gene 49A/G polymorphism in Turkish patients with Behçet's disease.
Sallakci N, Bacanli A, Coskun M, Yavuzer U, Alpsoy E, Yegin O
Clin Exp Dermatol. 2005
PubMed ID: 16045690
Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients.
Lorentzen AR, Celius EG, Ekstrøm PO, Wiencke K, Lie BA, Myhr KM, Ling V, Thorsby E, Vartdal F, Spurkland A, Harbo HF
J Neuroimmunol. 2005
PubMed ID: 16005527
CTLA-4 expression in T cells of patients with atopic dermatitis.
Choi SY, Sohn MH, Kwon BC, Kim KE
Pediatr Allergy Immunol. 2005
PubMed ID: 16101935
Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese.
Machida H, Tsukamoto K, Wen CY, Narumi Y, Shikuwa S, Isomoto H, Takeshima F, Mizuta Y, Niikawa N, Murata I, Kohno S
World J Gastroenterol. 2005
PubMed ID: 16015687
Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation.
Darlington PJ, Kirchhof MG, Criado G, Sondhi J, Madrenas J
J Immunol. 2005
PubMed ID: 16002699
Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.
Mazón Peláez I, Vogler S, Strauss U, Wernhoff P, Pahnke J, Brockmann G, Moch H, Thiesen HJ, Rolfs A, Ibrahim SM
Hum Mol Genet. 2005
PubMed ID: 15917267
Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups.
Guzman VB, Morgun A, Shulzhenko N, Mine KL, Gonçalves-Primo A, Musatti CC, Gerbase-Delima M
Hum Immunol. 2005
PubMed ID: 16112024
CTLA-4 gene polymorphisms in Chinese patients with ulcerative colitis.
Hou W, Xia B, Yuan A, Li J, Yang Z, Mao L
Inflamm Bowel Dis. 2005
PubMed ID: 15973119
ICOS contributes to T cell expansion in CTLA-4 deficient mice.
van Berkel ME, Schrijver EH, Hofhuis FM, Sharpe AH, Coyle AJ, Broeren CP, Tesselaar K, Oosterwegel MA
J Immunol. 2005
PubMed ID: 15972646
B7-independent inhibition of T cells by CTLA-4.
Chikuma S, Abbas AK, Bluestone JA
J Immunol. 2005
PubMed ID: 15972645
Association of CTLA4 polymorphism with regulatory T cell frequency.
Atabani SF, Thio CL, Divanovic S, Trompette A, Belkaid Y, Thomas DL, Karp CL
Eur J Immunol. 2005
PubMed ID: 15940668
The CTLA4 +49 A/G*G-CT60*G haplotype is associated with susceptibility to multiple sclerosis in Flanders.
Suppiah V, Alloza I, Heggarty S, Goris A, Dubois B, Carton H, Vandenbroeck K
J Neuroimmunol. 2005
PubMed ID: 15904974
Association of the CTLA-4 gene with rheumatoid arthritis in Chinese Han population.
Lei C, Dongqing Z, Yeqing S, Oaks MK, Lishan C, Jianzhong J, Jie Q, Fang D, Ningli L, Xinghai H, Daming R
Eur J Hum Genet. 2005
PubMed ID: 15841095
CTLA4-CD80/CD86 interactions on primary mouse CD4+ T cells integrate signal-strength information to modulate activation with Concanavalin A.
Mukherjee S, Ahmed A, Nandi D
J Leukoc Biol. 2005
PubMed ID: 15788440
Genetic analysis of the 2q33 region containing CD28-CTLA4-ICOS genes: association with non-Hodgkin's lymphoma.
Piras G, Monne M, Uras A, Palmas A, Murineddu M, Arru L, Bianchi A, Calvisi A, Curreli L, Gaviano E, Lai P, Murgia A, Latte GC, Noli A, Gabbas A
Br J Haematol. 2005
PubMed ID: 15953005
Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves' disease in a Polish population: association and gene dose-dependent correlation with age of onset.
Skórka A, Bednarczuk T, Bar-Andziak E, Nauman J, Ploski R
Clin Endocrinol (Oxf). 2005
PubMed ID: 15943829
Intrinsic tolerance in autologous collagen-induced arthritis is generated by CD152-dependent CD4+ suppressor cells.
Treschow AP, Bäcklund J, Holmdahl R, Issazadeh-Navikas S
J Immunol. 2005
PubMed ID: 15905514
Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo.
Ito T, Ueno T, Clarkson MR, Yuan X, Jurewicz MM, Yagita H, Azuma M, Sharpe AH, Auchincloss H, Sayegh MH, Najafian N
J Immunol. 2005
PubMed ID: 15905503
Exon-3 polymorphism of CTLA-4 gene in Turkish patients with vitiligo.
Itirli G, Pehlivan M, Alper S, Yüksel SE, Onay H, Ozkinay F, Pehlivan S
J Dermatol Sci. 2005
PubMed ID: 15888380
Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4.
Dillon TJ, Carey KD, Wetzel SA, Parker DC, Stork PJ
Mol Cell Biol. 2005
PubMed ID: 15870282
CTLA4 engagement is required for induction of murine liver transplant spontaneous tolerance.
Li W, Zheng XX, Kuhr CS, Perkins JD
Am J Transplant. 2005
PubMed ID: 15816877
CTLA-4 is important in maintaining long-term survival of cardiac allografts.
Chandraker A, Huurman V, Hallett K, Yuan X, Tector AJ, Park CH, Lu E, Zavazava N, Oaks M
Transplantation. 2005
PubMed ID: 15849541
Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells.
Mead KI, Zheng Y, Manzotti CN, Perry LC, Liu MK, Burke F, Powner DJ, Wakelam MJ, Sansom DM
J Immunol. 2005
PubMed ID: 15814706
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
Association of Epstein-Barr virus with systemic lupus erythematosus: effect modification by race, age, and cytotoxic T lymphocyte-associated antigen 4 genotype.
Parks CG, Cooper GS, Hudson LL, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, Pandey JP
Arthritis Rheum. 2005
PubMed ID: 15818712
CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis.
Lee YH, Harley JB, Nath SK
Hum Genet. 2005
PubMed ID: 15688186
A common CTLA4 haplotype associated with coeliac disease.
Hunt KA, McGovern DP, Kumar PJ, Ghosh S, Travis SP, Walters JR, Jewell DP, Playford RJ, van Heel DA
Eur J Hum Genet. 2005
PubMed ID: 15657618
Association of a CTLA-4 3' untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population.
Ban Y, Tozaki T, Taniyama M, Tomita M, Ban Y
Autoimmunity. 2005
PubMed ID: 16040335
CTLA4 gene polymorphism in Italian patients with colorectal adenoma and cancer.
Solerio E, Tappero G, Iannace L, Matullo G, Ayoubi M, Parziale A, Cicilano M, Sansoè G, Framarin L, Vineis P, Rosina F
Dig Liver Dis. 2005
PubMed ID: 15888281
Cytotoxic T-lymphocyte antigen 4 gene polymorphisms in sarcoidosis patients.
Hattori N, Niimi T, Sato S, Achiwa H, Maeda H, Oguri T, Bessho Y, Ito H, Shimizu S, Ueda R
Sarcoidosis Vasc Diffuse Lung Dis. 2005
PubMed ID: 15881277
Soluble CTLA-4 in sera of patients with bronchial asthma.
Shi HZ, Mo XY, Zhong XN
J Asthma. 2005
PubMed ID: 15871446
The polymorphisms -318C>T in the promoter and 49A>G in exon 1 of CTLA4 and the risk of aplastic anemia in a Caucasian population.
Svahn J, Capasso M, Lanciotti M, Marrone A, Haupt R, Bacigalupo A, Pongiglione C, Boschetto L, Longoni D, Pillon M, Pistorio A, Di Michele P, Iori AP, Calvillo M, Locasciulli A, Menna G, Riccardi R, Ramenghi U, Dufour C, Iolascon A
Bone Marrow Transplant. 2005
PubMed ID: 15812539
CT60 single nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen-4 gene region is associated with Graves' disease in an Italian population.
Petrone A, Giorgi G, Galgani A, Alemanno I, Corsello SM, Signore A, Di Mario U, Nisticò L, Cascino I, Buzzetti R
Thyroid. 2005
PubMed ID: 15785242
CTLA4/CT60 polymorphism is not relevant in susceptibility to autoimmune inflammatory intestinal disorders.
Rueda B, Zhernakova A, López-Nevot MA, Gomez-Garcia M, Ortega E, Piñero A, Correro F, Brieva JA, Nieto A, Koeleman BP, Martín J
Hum Immunol. 2005
PubMed ID: 15784471
Distinct tumour necrosis factor alpha, interferon gamma, interleukin 10, and cytotoxic T cell antigen 4 gene polymorphisms in disease occurrence and end stage renal disease in Wegener's granulomatosis.
Spriewald BM, Witzke O, Wassmuth R, Wenzel RR, Arnold ML, Philipp T, Kalden JR
Ann Rheum Dis. 2005
PubMed ID: 15708894
Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4.
Probst HC, McCoy K, Okazaki T, Honjo T, van den Broek M
Nat Immunol. 2005
PubMed ID: 15685176
Association of the A/G polymorphism at position 49 in exon 1 of CTLA-4 with the susceptibility to unexplained recurrent spontaneous abortion in the Chinese population.
Wang X, Lin Q, Ma Z, Hong Y, Zhao A, Di W, Lu P
Am J Reprod Immunol. 2005
PubMed ID: 15790344
CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese.
Fukazawa T, Kikuchi S, Miyagishi R, Niino M, Yabe I, Hamada T, Sasaki H
J Neuroimmunol. 2005
PubMed ID: 15652423
CTLA4 polymorphisms are associated with vitiligo, in patients with concomitant autoimmune diseases.
Blomhoff A, Kemp EH, Gawkrodger DJ, Weetman AP, Husebye ES, Akselsen HE, Lie BA, Undlien DE
Pigment Cell Res. 2005
PubMed ID: 15649153
CTLA-4 overexpression in CD19+/CD5+ cells correlates with the level of cell cycle regulators and disease progression in B-CLL patients.
Kosmaczewska A, Ciszak L, Suwalska K, Wolowiec D, Frydecka I
Leukemia. 2005
PubMed ID: 15549146
Anti-human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies.
May KF, Roychowdhury S, Bhatt D, Kocak E, Bai XF, Liu JQ, Ferketich AK, Martin EW, Caligiuri MA, Zheng P, Liu Y
Blood. 2005
PubMed ID: 15486062
Multiple negative feedbacks on CD152 expression in allograft tolerance.
Tsai MK, Ho HN, Chien HF, Tzeng MC, Chen CH, Lee PH
Transplantation. 2005
PubMed ID: 15665765
Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer.
Demaria S, Kawashima N, Yang AM, Devitt ML, Babb JS, Allison JP, Formenti SC
Clin Cancer Res. 2005
PubMed ID: 15701862
Expression of CD28 and CTLA4 on T cells in bone morrow of immune-mediated aplastic anemia mice.
Liu Z, Sun H, Liu W, Luo X, He L, Xu H
J Huazhong Univ Sci Technolog Med Sci. 2005
PubMed ID: 16463658
CT60 single nucleotide polymorphism of the CTLA-4 gene is associated with susceptibility to Graves' disease in the Taiwanese population.
Weng YC, Wu MJ, Lin WS
Ann Clin Lab Sci. 2005
PubMed ID: 16081581
Association of HLA-DR, -DQ genotype and CTLA-4 gene polymorphism with Graves' disease in Japanese children.
Iwama S, Ikezaki A, Kikuoka N, Kim HS, Matsuoka H, Yanagawa T, Sato H, Hoshi M, Sakamaki T, Sugihara S
Horm Res. 2005
PubMed ID: 15640608
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Heterozygosity in CTLA-4 gene and severe preeclampsia.
Samsami Dehaghani A, Doroudchi M, Kalantari T, Pezeshki AM, Ghaderi A
Int J Gynaecol Obstet. 2005
PubMed ID: 15617700
CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization.
van Wijk F, Hoeks S, Nierkens S, Koppelman SJ, van Kooten P, Boon L, Knippels LM, Pieters R
J Immunol. 2005
PubMed ID: 15611239
CTLA-4 engagement acts as a brake on CD4+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance.
Inobe M, Schwartz RH
J Immunol. 2004
PubMed ID: 15585846
Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
Li D, Gál I, Vermes C, Alegre ML, Chong AS, Chen L, Shao Q, Adarichev V, Xu X, Koreny T, Mikecz K, Finnegan A, Glant TT, Zhang J
J Immunol. 2004
PubMed ID: 15585834
High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy.
Huxley P, Sutton DH, Debnam P, Matthews IR, Brewer JE, Rose J, Trickett M, Williams DD, Andersen TB, Classon BJ
Chem Biol. 2004
PubMed ID: 15610849
Gender-limited association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphism with cord blood IgE levels.
Chang JC, Liu CA, Chuang H, Ou CY, Hsu TY, Huang EY, Yang KD
Pediatr Allergy Immunol. 2004
PubMed ID: 15610363
Role of CTLA-4 in the activation of single- and double-positive thymocytes.
Kwon H, Jun HS, Khil LY, Yoon JW
J Immunol. 2004
PubMed ID: 15557155
Cytotoxic T-lymphocyte antigen-4-CT60 polymorphism in rheumatoid arthritis.
Orozco G, Torres B, Núñez-Roldán A, González-Escribano MF, Martín J
Tissue Antigens. 2004
PubMed ID: 15546339
Analysis of 6 genetic loci for disease susceptibility in psoriatic arthritis.
Alenius GM, Friberg C, Nilsson S, Wahlström J, Dahlqvist SR, Samuelsson L
J Rheumatol. 2004
PubMed ID: 15517637
Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice.
Hwang KW, Sweatt WB, Mashayekhi M, Palucki DA, Sattar H, Chuang E, Alegre ML
J Immunol. 2004
PubMed ID: 15494488
Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function.
Tang Q, Boden EK, Henriksen KJ, Bour-Jordan H, Bi M, Bluestone JA
Eur J Immunol. 2004
PubMed ID: 15468055
Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population.
Fan LY, Tu XQ, Cheng QB, Zhu Y, Feltens R, Pfeiffer T, Zhong RQ
World J Gastroenterol. 2004
PubMed ID: 15378793
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
[Association of CTLA-4 promoter -1722 polymorphism with systemic lupus erythematosus in Chinese]
Xu AP, Yin PD, Su XY
Di Yi Jun Yi Da Xue Xue Bao. 2004
PubMed ID: 15485777
[Study on the relationship of CTLA-4 -318, +49 polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in a Chinese population]
Fan LY, Zhu Y, Zhong RQ, Tu XQ, Chen QB, Zhou L, Liu HY, Kong XT
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004
PubMed ID: 15476165
Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.
Thio CL, Mosbruger TL, Kaslow RA, Karp CL, Strathdee SA, Vlahov D, O'Brien SJ, Astemborski J, Thomas DL
J Virol. 2004
PubMed ID: 15452244
No evidence of association of CTLA4 polymorphisms with Addison's disease.
Pérez de Nanclares G, Martín-Pagola A, Ramón Bilbao J, Vázquez F, Castaño L
Autoimmunity. 2004
PubMed ID: 15621571
CTLA-4 (CD152) gene polymorphism at position 49 in exon 1 in Graves' disease in a Polish population of the Lower Silesian region.
Frydecka I, Daroszewski J, Suwalska K, Zołedziowska M, Tutak A, Słowik M, Potoczek S, Dobosz T
Arch Immunol Ther Exp (Warsz). 2004
PubMed ID: 15507878
B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse.
Pentcheva-Hoang T, Egen JG, Wojnoonski K, Allison JP
Immunity. 2004
PubMed ID: 15357951
Analysis of immune regulatory genes in familial and sporadic Graves' disease.
Ban Y, Concepcion ES, Villanueva R, Greenberg DA, Davies TF, Tomer Y
J Clin Endocrinol Metab. 2004
PubMed ID: 15356063
CTLA4 +49 A/G and CT60 polymorphisms in Dutch coeliac disease patients.
van Belzen MJ, Mulder CJ, Zhernakova A, Pearson PL, Houwen RH, Wijmenga C
Eur J Hum Genet. 2004
PubMed ID: 15199380
B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus.
Zheng X, Gao JX, Chang X, Wang Y, Liu Y, Wen J, Zhang H, Zhang J, Liu Y, Zheng P
J Immunol. 2004
PubMed ID: 15294937
An analysis of CTLA-4 and proinflammatory cytokine genes in Wegener's granulomatosis.
Zhou Y, Huang D, Paris PL, Sauter CS, Prock KA, Hoffman GS
Arthritis Rheum. 2004
PubMed ID: 15334480
CTLA-4 polymorphisms in allergy and asthma and the TH1/ TH2 paradigm.
Munthe-Kaas MC, Carlsen KH, Helms PJ, Gerritsen J, Whyte M, Feijen M, Skinningsrud B, Main M, Kwong GN, Lie BA, Lødrup Carlsen KC, Undlien DE
J Allergy Clin Immunol. 2004
PubMed ID: 15316504
Overexpression of a mutant CTLA4 inhibits T-cell activation and homeostasis-driven expansion.
Mao Y, Brigham D, Chen D
Exp Hematol. 2004
PubMed ID: 15308325
Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus.
Barreto M, Santos E, Ferreira R, Fesel C, Fontes MF, Pereira C, Martins B, Andreia R, Viana JF, Crespo F, Vasconcelos C, Ferreira C, Vicente AM
Eur J Hum Genet. 2004
PubMed ID: 15138458
Association of the CT60 marker of the CTLA4 gene with systemic lupus erythematosus.
Torres B, Aguilar F, Franco E, Sánchez E, Sánchez-Román J, Jiménez Alonso J, Núñez-Roldán A, Martín J, González-Escribano MF
Arthritis Rheum. 2004
PubMed ID: 15248219
Cytotoxic T lymphocyte antigen-4 gene in breast cancer.
Ghaderi A, Yeganeh F, Kalantari T, Talei AR, Pezeshki AM, Doroudchi M, Dehaghani AS
Breast Cancer Res Treat. 2004
PubMed ID: 15218356
Cytotoxic T-lymphocyte antigen-4 A49G polymorphism is associated with susceptibility to and severity of alcoholic liver disease in Italian patients.
Valenti L, De Feo T, Fracanzani AL, Fatta E, Salvagnini M, Aricò S, Rossi G, Fiorelli G, Fargion S
Alcohol Alcohol. 2004
PubMed ID: 15208156
Progression of multiple sclerosis is associated with exon 1 CTLA-4 gene polymorphism.
Bilińska M, Frydecka I, Noga L, Dobosz T, Zołedziewska M, Suwalska K, Tutak A, Pokryszko-Dragan A
Acta Neurol Scand. 2004
PubMed ID: 15180809
MHC class II-independent and -dependent T cell expansion and B cell hyperactivity in vivo in mice deficient in CD152 (CTLA-4).
Stohl W, Xu D, Kim KS, David CS, Allison JP
Int Immunol. 2004
PubMed ID: 15136557
CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance.
Eagar TN, Turley DM, Padilla J, Karandikar NJ, Tan L, Bluestone JA, Miller SD
J Immunol. 2004
PubMed ID: 15187122
CTLA-4 gene polymorphism and its association with Graves' disease in the Lebanese population.
Nakkash-Chmaisse H, Makki RF, Abdelhamid E, Fakhoury H, Salti NN, Salti I
Eur J Immunogenet. 2004
PubMed ID: 15182328
Conversion of CTLA-4 from inhibitor to activator of T cells with a bispecific tandem single-chain Fv ligand.
Madrenas J, Chau LA, Teft WA, Wu PW, Jussif J, Kasaian M, Carreno BM, Ling V
J Immunol. 2004
PubMed ID: 15128776
Involvement of CTLA-4 in T-cell anergy induced by staphylococcal enterotoxin A in vitro.
Xu GL, Zhu XH, Guo B, Wu YZ
Mol Immunol. 2004
PubMed ID: 15140570
Cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene polymorphism and susceptibility to non-Hodgkin's lymphoma.
Monne M, Piras G, Palmas A, Arru L, Murineddu M, Latte G, Noli A, Gabbas A
Am J Hematol. 2004
PubMed ID: 15114591
CTLA-4 blockage increases resistance to infection with the intracellular protozoan Trypanosoma cruzi.
Martins GA, Tadokoro CE, Silva RB, Silva JS, Rizzo LV
J Immunol. 2004
PubMed ID: 15067068
Association of CTLA-4 gene polymorphism with oral submucous fibrosis in Taiwan.
Shin YN, Liu CJ, Chang KW, Lee YJ, Liu HF
J Oral Pathol Med. 2004
PubMed ID: 15061706
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo.
Yi LA, Hajialiasgar S, Chuang E
Int Immunol. 2004
PubMed ID: 15039384
CTLA-4+CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation.
Sugita S, Ng TF, Schwartzkopff J, Streilein JW
J Immunol. 2004
PubMed ID: 15034031
CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function.
Pandiyan P, Gärtner D, Soezeri O, Radbruch A, Schulze-Osthoff K, Brunner-Weinzierl MC
J Exp Med. 2004
PubMed ID: 15007096
[Association between the cytotoxic T lymphocyte antigen-4 gene microsatellite polymorphism and inflammatory bowel diseases in the Chinese]
Jiang Y, Xia B
Zhonghua Nei Ke Za Zhi. 2004
PubMed ID: 15059373
Structural and functional analysis of the costimulatory receptor programmed death-1.
Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC
Immunity. 2004
PubMed ID: 15030777
The role of B7 molecules in the cell contact-mediated suppression of T cell mitogenesis by immunosuppressive macrophages induced with mycobacterial infection.
Shimizu T, Sano C, Tomioka H
Clin Exp Immunol. 2004
PubMed ID: 15008968
Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients.
Teutsch SM, Booth DR, Bennetts BH, Heard RN, Stewart GJ
J Neuroimmunol. 2004
PubMed ID: 14975605
Two different forms of human CTLA-4 proteins following peripheral T cell activation.
Chun T, Choi HJ, Chung YH
Immunol Lett. 2004
PubMed ID: 15019292
Schistosoma mansoni PIII antigen modulates in vitro granuloma formation by regulating CD28, CTLA-4, and CD86 expression in humans.
Zouain CS, Falcão PL, Goes TS, Leite MF, Goes AM
Immunol Lett. 2004
PubMed ID: 15019278
Complex genetic predisposition in adult and juvenile rheumatoid arthritis.
Miterski B, Drynda S, Böschow G, Klein W, Oppermann J, Kekow J, Epplen JT
BMC Genet. 2004
PubMed ID: 15018649
No evidence for an association of the CTLA4 gene with bipolar I disorder.
Jun TY, Lee KU, Pae CU, Kweon YS, Chae JH, Bahk WM, Kim KS, Lew TY, Han H
Psychiatry Clin Neurosci. 2004
PubMed ID: 14678452
The cytotoxic potential of regulatory T cells: what has been learned from gene knockout model systems?
Marks L, Levy RB
Transplantation. 2004
PubMed ID: 14726764
The role of B7 ligands (CD80 and CD86) in CD152-mediated allograft tolerance: a crosscheck hypothesis.
Tsai MK, Ho HN, Chien HF, Ou-Yang P, Lee CJ, Lee PH
Transplantation. 2004
PubMed ID: 14724434
CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States.
Parks CG, Hudson LL, Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, Pandey JP
Lupus. 2004
PubMed ID: 15540511
Association of the T-cell regulatory gene CTLA4 with Graves' disease and autoimmune thyroid disease in the Japanese.
Furugaki K, Shirasawa S, Ishikawa N, Ito K, Ito K, Kubota S, Kuma K, Tamai H, Akamizu T, Hiratani H, Tanaka M, Sasazuki T
J Hum Genet. 2004
PubMed ID: 14986169
A CTLA-4 polymorphism associated with susceptibility to systemic lupus erythematosus.
Fernandez-Blanco L, Perez-Pampin E, Gomez-Reino JJ, Gonzalez A
Arthritis Rheum. 2004
PubMed ID: 14730632
Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases.
Yang KD, Liu CA, Chang JC, Chuang H, Ou CY, Hsu TY, Wang CL
Clin Exp Allergy. 2004
PubMed ID: 14720259
Cytotoxic T lymphocyte-associated molecule-4 polymorphism and relapse of Graves' hyperthyroidism after antithyroid withdrawal.
Wang PW, Liu RT, Juo SH, Wang ST, Hu YH, Hsieh CJ, Chen MH, Chen IY, Wu CL
J Clin Endocrinol Metab. 2004
PubMed ID: 14715845
Ethnic differences in cytotoxic T lymphocyte associated antigen 4 genotype associations with systemic sclerosis.
Hudson LL, Silver RM, Pandey JP
J Rheumatol. 2004
PubMed ID: 14705224
Interactions of HLA-DRB4 and CTLA-4 genes influence thyroid function in Hashimoto's thyroiditis in Japanese population.
Terauchi M, Yanagawa T, Ishikawa N, Ito K, Fukazawa T, Maruyama H, Saruta T
J Endocrinol Invest. 2003
PubMed ID: 15055474
CTLA-4 AT-repeat polymorphism reduces the inhibitory function of CTLA-4 in Graves' disease.
Takara M, Kouki T, DeGroot LJ
Thyroid. 2003
PubMed ID: 14751028
Recipient ctla-4 +49 G/G genotype is associated with reduced incidence of acute rejection after liver transplantation.
de Reuver P, Pravica V, Hop W, Boor P, Metselaar HJ, Hutchinson IV, Tilanus HW, Kwekkeboom J
Am J Transplant. 2003
PubMed ID: 14629291
Promoter polymorphism of IL-10 and severity of multiple sclerosis.
Luomala M, Lehtimäki T, Huhtala H, Ukkonen M, Koivula T, Hurme M, Elovaara I
Acta Neurol Scand. 2003
PubMed ID: 14616291
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4.
Liu H, Hu B, Xu D, Liew FY
J Immunol. 2003
PubMed ID: 14607897
Cytotoxic T-lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism affects lymphocyte profiles in bronchoalveolar lavage of patients with sarcoidosis.
Handa T, Nagai S, Ito I, Shigematsu M, Hamada K, Kitaichi M, Izumi T, Mishima M
Sarcoidosis Vasc Diffuse Lung Dis. 2003
PubMed ID: 14620161
CTLA4 polymorphism in Spanish patients with systemic lupus erythematosus.
Aguilar F, Torres B, Sánchez-Román J, Núñez-Roldán A, González-Escribano MF
Hum Immunol. 2003
PubMed ID: 14522090
Diversity of clonal T cell proliferation is mediated by differential expression of CD152 (CTLA-4) on the cell surface of activated individual T lymphocytes.
Maszyna F, Hoff H, Kunkel D, Radbruch A, Brunner-Weinzierl MC
J Immunol. 2003
PubMed ID: 14500641
Association of CTLA4 gene A-G polymorphism with rheumatoid arthritis in Chinese.
Lee CS, Lee YJ, Liu HF, Su CH, Chang SC, Wang BR, Chen TL, Liu TL
Clin Rheumatol. 2003
PubMed ID: 14505215
CD28/CTLA4 double deficient mice demonstrate crucial role for B7 co-stimulation in the induction of allergic lower airways disease.
Deurloo DT, van Berkel MA, van Esch BC, Hofhuis F, Nijkamp FP, Oosterwegel MA, van Oosterhout AJ
Clin Exp Allergy. 2003
PubMed ID: 12956753
Analysis of major histocompatibility complex and CTLA-4 alleles in Brazilian patients with primary biliary cirrhosis.
Bittencourt PL, Palácios SA, Farias AQ, Abrantes-Lemos CP, Cançado EL, Carrilho FJ, Laudanna AA, Kalil J, Goldberg AC
J Gastroenterol Hepatol. 2003
PubMed ID: 12911663
Exon-1 polymorphism of ctla-4 gene in Iranian patients with Graves' disease.
Kalantari T, Mostafavi H, Pezeshki AM, Farjadian S, Doroudchi M, Yeganeh F, Ghaderi A
Autoimmunity. 2003
PubMed ID: 14567561
CTLA-4 and its role in autoimmune thyroid disease.
Chistiakov DA, Turakulov RI
J Mol Endocrinol. 2003
PubMed ID: 12914522
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma.
Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, Restifo NP, Haworth LR, Seipp CA, Freezer LJ, Morton KE, Mavroukakis SA, Duray PH, Steinberg SM, Allison JP, Davis TA, Rosenberg SA
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12826605
Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4.
Sugita S, Streilein JW
J Exp Med. 2003
PubMed ID: 12835481
CTLA-4 dimorphisms in Japanese patients with systemic lupus erythematosus.
Takeuchi F, Kawasugi K, Nabeta H, Mori M, Tanimoto K
Clin Exp Rheumatol. 2003
PubMed ID: 12942714
Cytotoxic T lymphocyte antigen-4 gene polymorphisms do not confer susceptibility to autoimmune hepatitis types 1 and 2 in Brazil.
Bittencourt PL, Palácios SA, Cançado EL, Porta G, Carrilho FJ, Laudanna AA, Kalil J, Goldberg AC
Am J Gastroenterol. 2003
PubMed ID: 12873588
CTLA-4 and CD28 gene polymorphisms in susceptibility, clinical course and progression of multiple sclerosis.
van Veen T, Crusius JB, van Winsen L, Xia B, Barkhof F, Salvador Peña A, Polman CH, Uitdehaag BM
J Neuroimmunol. 2003
PubMed ID: 12864988
Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitis.
Tsuchiya N, Kobayashi S, Kawasaki A, Kyogoku C, Arimura Y, Yoshida M, Tokunaga K, Hashimoto H
J Rheumatol. 2003
PubMed ID: 12858454
Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients.
Alizadeh M, Babron MC, Birebent B, Matsuda F, Quelvennec E, Liblau R, Cournu-Rebeix I, Momigliano-Richiardi P, Sequeiros J, Yaouanq J, Genin E, Vasilescu A, Bougerie H, Trojano M, Martins Silva B, Maciel P, Clerget-Darpoux F, Clanet M, Edan G, Fontaine B, Semana G
Ann Neurol. 2003
PubMed ID: 12838528
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM
Nat Immunol. 2003
PubMed ID: 12796776
CTLA-4. FasL induces alloantigen-specific hyporesponsiveness.
Elhalel MD, Huang JH, Schmidt W, Rachmilewitz J, Tykocinski ML
J Immunol. 2003
PubMed ID: 12794109
Increased expression of soluble cytotoxic T-lymphocyte-associated antigen-4 molecule in patients with systemic lupus erythematosus.
Liu MF, Wang CR, Chen PC, Fung LL
Scand J Immunol. 2003
PubMed ID: 12791095
CTLA4 gene and Graves' disease: association of Graves' disease with the CTLA4 exon 1 and intron 1 polymorphisms, but not with the promoter polymorphism.
Vaidya B, Oakes EJ, Imrie H, Dickinson AJ, Perros P, Kendall-Taylor P, Pearce SH
Clin Endocrinol (Oxf). 2003
PubMed ID: 12780750
A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
Buhlmann JE, Elkin SK, Sharpe AH
J Immunol. 2003
PubMed ID: 12759417
Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigen.
Shirasugi N, Akiyama Y, Aramaki O, Shibutani S, Matsumoto K, Bashuda H, Yagita H, Okumura K, Ikeda Y, Niimi M
Transplantation. 2003
PubMed ID: 12777848
A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus.
Watanabe I, Tomita A, Shimizu M, Sugawara M, Yasumo H, Koishi R, Takahashi T, Miyoshi K, Nakamura K, Izumi T, Matsushita Y, Furukawa H, Haruyama H, Koga T
Clin Pharmacol Ther. 2003
PubMed ID: 12732844
Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis.
Campanelli AP, Martins GA, Souto JT, Pereira MS, Livonesi MC, Martinez R, Silva JS
J Infect Dis. 2003
PubMed ID: 12717632
c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity.
Goto E, Ishido S, Sato Y, Ohgimoto S, Ohgimoto K, Nagano-Fujii M, Hotta H
J Biol Chem. 2003
PubMed ID: 12582153
Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection.
Yee LJ, Perez KA, Tang J, van Leeuwen DJ, Kaslow RA
J Infect Dis. 2003
PubMed ID: 12696006
An essential role for Scurfin in CD4+CD25+ T regulatory cells.
Khattri R, Cox T, Yasayko SA, Ramsdell F
Nat Immunol. 2003
PubMed ID: 12612581
Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling.
Zhang X, Schwartz JC, Almo SC, Nathenson SG
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12606712
CTLA-4 engagement inhibits Th2 but not Th1 cell polarisation.
Ubaldi V, Gatta L, Pace L, Doria G, Pioli C
Clin Dev Immunol. 2003
PubMed ID: 14575153
Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination.
Butterfield RJ, Roper RJ, Rhein DM, Melvold RW, Haynes L, Ma RZ, Doerge RW, Teuscher C
Genetics. 2003
PubMed ID: 12663542
CTLA-4 in filarial infections: implications for a role in diminished T cell reactivity.
Steel C, Nutman TB
J Immunol. 2003
PubMed ID: 12574361
CTLA-4 +49 A/G dimorphism in Italian patients with celiac disease.
Mora B, Bonamico M, Indovina P, Megiorni F, Ferri M, Carbone MC, Cipolletta E, Mazzilli MC
Hum Immunol. 2003
PubMed ID: 12559633
CTLA-4 exon 1 polymorphism in patients with autoimmune blood disorders.
Pavkovic M, Georgievski B, Cevreska L, Spiroski M, Efremov DG
Am J Hematol. 2003
PubMed ID: 12555221
Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease.
Vidali M, Stewart SF, Rolla R, Daly AK, Chen Y, Mottaran E, Jones DE, Leathart JB, Day CP, Albano E
Hepatology. 2003
PubMed ID: 12540792
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA
Nat Immunol. 2003
PubMed ID: 12524538
Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.
Chikuma S, Imboden JB, Bluestone JA
J Exp Med. 2003
PubMed ID: 12515820
Population frequencies of single nucleotide polymorphisms (SNPs) in immuno-modulatory genes.
Martin AM, Athanasiadis G, Greshock JD, Fisher J, Lux MP, Calzone K, Rebbeck TR, Weber BL
Hum Hered. 2003
PubMed ID: 14566095
Lack of association between an exon 1 CTLA-4 gene polymorphism A(49)G and multiple sclerosis in a Polish population of the Lower Silesia region.
Boćko D, Bilińska M, Dobosz T, Zołedziewska M, Suwalska K, Tutak A, Gruszka E, Frydecka I
Arch Immunol Ther Exp (Warsz). 2003
PubMed ID: 12894875
Inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity modulates surface expression of CTLA-4 in stress-induced abortions.
Rüter J, Demuth HU, Arck PC, Hoffmann T, Klapp BF, Hildebrandt M
Adv Exp Med Biol. 2003
PubMed ID: 12675235
Anti-CD28 has a potent adjuvant effect on the antibody response to soluble antigens mediated through CTLA-4 by-pass.
Carlring J, Barr TA, Buckle AM, Heath AW
Eur J Immunol. 2003
PubMed ID: 12594842
Association of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene polymorphism and non-genetic factors with Graves' ophthalmopathy in European and Japanese populations.
Bednarczuk T, Hiromatsu Y, Fukutani T, Jazdzewski K, Miskiewicz P, Osikowska M, Nauman J
Eur J Endocrinol. 2003
PubMed ID: 12534352
Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA-4 to a positive signaling receptor.
Yin L, Schneider H, Rudd CE
J Leukoc Biol. 2003
PubMed ID: 12525576
CTLA4 is associated with susceptibility to multiple sclerosis.
Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, Waliszewska A, Buckle G, McMurray CT, de Andrade M, Hafler DA, Weinshenker BG
J Neuroimmunol. 2003
PubMed ID: 12507781
Established T cell-driven germinal center B cell proliferation is independent of CD28 signaling but is tightly regulated through CTLA-4.
Walker LS, Wiggett HE, Gaspal FM, Raykundalia CR, Goodall MD, Toellner KM, Lane PJ
J Immunol. 2003
PubMed ID: 12496387
CTLA-4 is not restricted to the lymphoid cell lineage and can function as a target molecule for apoptosis induction of leukemic cells.
Pistillo MP, Tazzari PL, Palmisano GL, Pierri I, Bolognesi A, Ferlito F, Capanni P, Polito L, Ratta M, Pileri S, Piccioli M, Basso G, Rissotto L, Conte R, Gobbi M, Stirpe F, Ferrara GB
Blood. 2003
PubMed ID: 12393538
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Cyclic adenosine 5'-monophosphate and calcium induce CD152 (CTLA-4) up-regulation in resting CD4+ T lymphocytes.
Vendetti S, Riccomi A, Sacchi A, Gatta L, Pioli C, De Magistris MT
J Immunol. 2002
PubMed ID: 12444128
A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele.
Anjos S, Nguyen A, Ounissi-Benkalha H, Tessier MC, Polychronakos C
J Biol Chem. 2002
PubMed ID: 12244107
Association of CTLA-4 with systemic sclerosis in Japanese patients.
Takeuchi F, Kawasugi K, Nabeta H, Mori M, Tanimoto K
Clin Exp Rheumatol. 2002
PubMed ID: 12508774
CTLA4 gene polymorphisms in Dutch and Chinese patients with inflammatory bowel disease.
Xia B, Crusius JB, Wu J, Zwiers A, van Bodegraven AA, Peña AS
Scand J Gastroenterol. 2002
PubMed ID: 12465728
Role of CD80, CD86, and CTLA4 on mouse CD4(+) T lymphocytes in enhancing cell-cycle progression and survival after activation with PMA and ionomycin.
Mukherjee S, Maiti PK, Nandi D
J Leukoc Biol. 2002
PubMed ID: 12429713
CTLA4 exon 1 dimorphism is associated with primary progressive multiple sclerosis.
Mäurer M, Ponath A, Kruse N, Rieckmann P
J Neuroimmunol. 2002
PubMed ID: 12458055
CTLA4 dimorphisms and the multiple sclerosis phenotype.
Masterman T, Ligers A, Zhang Z, Hellgren D, Salter H, Anvret M, Hillert J
J Neuroimmunol. 2002
PubMed ID: 12458054
CTLA-4 gene polymorphisms in systemic lupus erythematosus: a highly significant association with a determinant in the promoter region.
Hudson LL, Rocca K, Song YW, Pandey JP
Hum Genet. 2002
PubMed ID: 12384790
CTLA-4 expression on antigen-specific cells but not IL-10 secretion is required for oral tolerance.
Fowler S, Powrie F
Eur J Immunol. 2002
PubMed ID: 12355454
Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells.
Manzotti CN, Tipping H, Perry LC, Mead KI, Blair PJ, Zheng Y, Sansom DM
Eur J Immunol. 2002
PubMed ID: 12355442
Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size.
Sho M, Yamada A, Najafian N, Salama AD, Harada H, Sandner SE, Sanchez-Fueyo A, Zheng XX, Strom TB, Sayegh MH
J Immunol. 2002
PubMed ID: 12244168
Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice.
Schneider H, Mandelbrot DA, Greenwald RJ, Ng F, Lechler R, Sharpe AH, Rudd CE
J Immunol. 2002
PubMed ID: 12244135
B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice.
Akiyama Y, Shirasugi N, Uchida N, Matsumoto K, Kitajima M, Bashuda H, Yagita H, Okumura K, Aramaki O, Niimi M
Transplantation. 2002
PubMed ID: 12352894
Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors.
Riley JL, Mao M, Kobayashi S, Biery M, Burchard J, Cavet G, Gregson BP, June CH, Linsley PS
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12195015
Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence.
Wang XB, Kakoulidou M, Giscombe R, Qiu Q, Huang D, Pirskanen R, Lefvert AK
J Neuroimmunol. 2002
PubMed ID: 12225905
Murine malaria is exacerbated by CTLA-4 blockade.
Jacobs T, Graefe SE, Niknafs S, Gaworski I, Fleischer B
J Immunol. 2002
PubMed ID: 12193697
Re-establishing peripheral tolerance in the absence of CTLA-4: complementation by wild-type T cells points to an indirect role for CTLA-4.
Tivol EA, Gorski J
J Immunol. 2002
PubMed ID: 12165509
Cytotoxic T-lymphocyte antigen-4 gene polymorphisms and human T-cell lymphotrophic virus-1 infection: their associations with Hashimoto's thyroiditis in Japanese patients.
Tomoyose T, Komiya I, Takara M, Yabiku K, Kinjo Y, Shimajiri Y, Yogi H, Kouki T, Masuda M, Takasu N
Thyroid. 2002
PubMed ID: 12225635
Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Hwang KW, Sweatt WB, Brown IE, Blank C, Gajewski TF, Bluestone JA, Alegre ML
J Immunol. 2002
PubMed ID: 12097362
CTLA-4 upregulation during aging.
Leng Q, Bentwich Z, Borkow G
Mech Ageing Dev. 2002
PubMed ID: 12297345
[Polymorphism A/G in position +49 of CTLA4 exon 1 in multiple sclerosis in Russians]
Andreevskiĭ TV, Sudomoina MA, Gusev EI, Boĭko AN, Alekseenkov AD, Favorova OO
Mol Biol (Mosk). 2002
PubMed ID: 12173468
Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes.
Miller RE, Fayen JD, Mohammad SF, Stein K, Kadereit S, Woods KD, Sramkoski RM, Jacobberger JW, Templeton D, Shurin SB, Laughlin MJ
Exp Hematol. 2002
PubMed ID: 12135671
Association of asthma severity and bronchial hyperresponsiveness with a polymorphism in the cytotoxic T-lymphocyte antigen-4 gene.
Lee SY, Lee YH, Shin C, Shim JJ, Kang KH, Yoo SH, In KH
Chest. 2002
PubMed ID: 12114354
The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor.
Chambers CA, Kang J, Wu Y, Held W, Raulet DH, Allison JP
Blood. 2002
PubMed ID: 12036882
Cell surface expression of the HIV-1 envelope glycoproteins is directed from intracellular CTLA-4-containing regulated secretory granules.
Miranda LR, Schaefer BC, Kupfer A, Hu Z, Franzusoff A
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12060749
Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2.
Zhang X, Schwartz JC, Almo SC, Nathenson SG
Protein Expr Purif. 2002
PubMed ID: 12071705
A CTLA-4 gene polymorphism at position -318 in the promoter region affects the expression of protein.
Wang XB, Zhao X, Giscombe R, Lefvert AK
Genes Immun. 2002
PubMed ID: 12058260
Remission of Graves' hyperthyroidism and A/G polymorphism at position 49 in exon 1 of cytotoxic T lymphocyte-associated molecule-4 gene.
Kinjo Y, Takasu N, Komiya I, Tomoyose T, Takara M, Kouki T, Shimajiri Y, Yabiku K, Yoshimura H
J Clin Endocrinol Metab. 2002
PubMed ID: 12050220
Long-term therapy with recombinant human erythropoietin decreases percentage of CD152(+) lymphocytes in primary glomerulonephritis haemodialysis patients.
Trzonkowski P, Myśliwska J, Debska-Slizień A, Bryl E, Rachoń D, Myśliwski A, Rutkowski B
Nephrol Dial Transplant. 2002
PubMed ID: 12032199
Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation.
Darlington PJ, Baroja ML, Chau TA, Siu E, Ling V, Carreno BM, Madrenas J
J Exp Med. 2002
PubMed ID: 12021313
Polymorphism of CTLA-4 gene at position 49 of exon 1 may be associated with schizophrenia in the Korean population.
Jun TY, Pae CU, Chae JH, Bahk WM, Kim KS, Han H
Psychiatry Res. 2002
PubMed ID: 12007590
Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A.
Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J, Kuchroo VK
J Immunol. 2002
PubMed ID: 11994459
The influence of the exon 1 polymorphism of the cytotoxic T lymphocyte antigen 4 gene on thyroid antibody production in patients with newly diagnosed Graves' disease.
Zaletel K, Krhin B, Gaberscek S, Pirnat E, Hojker S
Thyroid. 2002
PubMed ID: 12097196
CTLA-4 gene A-G polymorphism and childhood Graves' disease.
Yung E, Cheng PS, Fok TF, Wong GW
Clin Endocrinol (Oxf). 2002
PubMed ID: 12030917
Coding sequence 1 and promoter single nucleotide polymorphisms in the CTLA-4 gene in Wegener's granulomatosis.
Giscombe R, Wang X, Huang D, Lefvert AK
J Rheumatol. 2002
PubMed ID: 12022356
Structural mechanisms of costimulation.
Schwartz JC, Zhang X, Nathenson SG, Almo SC
Nat Immunol. 2002
PubMed ID: 11976720
Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11.
Hsu HC, Mountz JD, Williams RW, Shelton BJ, Yang PA, Matsuki Y, Xu X, Dodd CH, Li L, Geiger H, Zhang HG, Van Zant G
Mech Ageing Dev. 2002
PubMed ID: 12044964
B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo.
Bai XF, Liu J, May KF, Guo Y, Zheng P, Liu Y
Blood. 2002
PubMed ID: 11929778
The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance.
Eagar TN, Karandikar NJ, Bluestone JA, Miller SD
Eur J Immunol. 2002
PubMed ID: 11920563
Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia.
LaBelle JL, Hanke CA, Blazar BR, Truitt RL
Blood. 2002
PubMed ID: 11877291
Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice.
Hurwitz AA, Sullivan TJ, Sobel RA, Allison JP
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11867713
Relation of three polymorphisms of the CTLA-4 gene in patients with Graves' disease.
Kouki T, Gardine CA, Yanagawa T, Degroot LJ
J Endocrinol Invest. 2002
PubMed ID: 11936461
CTLA-4 and autoimmune thyroid disease: lack of influence of the A49G signal peptide polymorphism on functional recombinant human CTLA-4.
Xu Y, Graves PN, Tomer Y, Davies TF
Cell Immunol. 2002
PubMed ID: 12202150
CDS1 and promoter single nucleotide polymorphisms of the CTLA-4 gene in human myasthenia gravis.
Wang XB, Kakoulidou M, Qiu Q, Giscombe R, Huang D, Pirskanen R, Lefvert AK
Genes Immun. 2002
PubMed ID: 11857062
CTLA-4 regulates cell cycle progression during a primary immune response.
Greenwald RJ, Oosterwegel MA, van der Woude D, Kubal A, Mandelbrot DA, Boussiotis VA, Sharpe AH
Eur J Immunol. 2002
PubMed ID: 11807776
No association of polymorphisms of the CTLA-4 exon 1(+49) and promoter(-318) genes with rheumatoid arthritis in the Korean population.
Lee YH, Choi SJ, Ji JD, Song GG
Scand J Rheumatol. 2002
PubMed ID: 12455815
Association of the CTLA4 3' untranslated region polymorphism with the susceptibility to rheumatoid arthritis.
Rodríguez MR, Núñez-Roldán A, Aguilar F, Valenzuela A, García A, González-Escribano MF
Hum Immunol. 2002
PubMed ID: 11916172
Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom.
Nithiyananthan R, Heward JM, Allahabadia A, Franklyn JA, Gough SC
Thyroid. 2002
PubMed ID: 11842815
CTLA-4/CD28 gene region is associated with genetic susceptibility to coeliac disease in UK families.
King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ellis HJ, Ciclitira PJ
J Med Genet. 2002
PubMed ID: 11826026
Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells.
Saverino D, Merlo A, Bruno S, Pistoia V, Grossi CE, Ciccone E
J Immunol. 2002
PubMed ID: 11751964
HLA-DQB1 CAR1/CAR2, TNFa IR2/IR4 and CTLA-4 polymorphisms in Tunisian patients with rheumatoid arthritis and Sjögren's syndrome.
Hadj Kacem H, Kaddour N, Adyel FZ, Bahloul Z, Ayadi H
Rheumatology (Oxford). 2001
PubMed ID: 11752507
Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.
Ling V, Wu PW, Finnerty HF, Agostino MJ, Graham JR, Chen S, Jussiff JM, Fisk GJ, Miller CP, Collins M
Genomics. 2001
PubMed ID: 11735222
CTLA-4 gene polymorphisms in Tunisian patients with Graves' disease.
Hadj Kacem H, Bellassoued M, Bougacha-Elleuch N, Abid M, Ayadi H
Clin Immunol. 2001
PubMed ID: 11726229
A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice.
Farmer MA, Sundberg JP, Bristol IJ, Churchill GA, Li R, Elson CO, Leiter EH
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11707574
CTLA-4 is not required for induction of CD8(+) T cell anergy in vivo.
Frauwirth KA, Alegre ML, Thompson CB
J Immunol. 2001
PubMed ID: 11673499
Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28.
Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, Rowsell S, Stacey CL, Stanway JJ, Taylor IW, Abbott WM
Biochem J. 2001
PubMed ID: 11583591
Polymorphism of CTLA-4 gene for major depression in the Korean population.
Jun TY, Pae CU, Chae JH, Bahk WM, Kim KS
Psychiatry Clin Neurosci. 2001
PubMed ID: 11555351
MHC class II region, CTLA4 gene, and ophthalmopathy in patients with Graves' disease.
Allahabadia A, Heward JM, Nithiyananthan R, Gibson SM, Reuser TT, Dodson PM, Franklyn JA, Gough SC
Lancet. 2001
PubMed ID: 11583755
B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis.
Liu Z, Geboes K, Hellings P, Maerten P, Heremans H, Vandenberghe P, Boon L, van Kooten P, Rutgeerts P, Ceuppens JL
J Immunol. 2001
PubMed ID: 11466409
Polymorphism in codon 17 of the CTLA-4 gene (+49 A/G) is not associated with susceptibility to rheumatoid arthritis in British Caucasians.
Milicic A, Brown MA, Wordsworth BP
Tissue Antigens. 2001
PubMed ID: 11580858
Association of CTLA-4 but not CD28 gene polymorphisms with systemic lupus erythematosus in the Japanese population.
Ahmed S, Ihara K, Kanemitsu S, Nakashima H, Otsuka T, Tsuzaka K, Takeuchi T, Hara T
Rheumatology (Oxford). 2001
PubMed ID: 11426024
B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.
Mandelbrot DA, Oosterwegel MA, Shimizu K, Yamada A, Freeman GJ, Mitchell RN, Sayegh MH, Sharpe AH
J Clin Invest. 2001
PubMed ID: 11285307
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.
Stamper CC, Zhang Y, Tobin JF, Erbe DV, Ikemizu S, Davis SJ, Stahl ML, Seehra J, Somers WS, Mosyak L
Nature. 2001
PubMed ID: 11279502
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
Schwartz JC, Zhang X, Fedorov AA, Nathenson SG, Almo SC
Nature. 2001
PubMed ID: 11279501
Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase.
Gajewski TF, Fallarino F, Fields PE, Rivas F, Alegre ML
J Immunol. 2001
PubMed ID: 11238634
CTLA4 in multiple sclerosis. Lack of genetic association in a European Caucasian population but evidence of interaction with HLA-DR2 among Shanghai Chinese.
Rasmussen HB, Kelly MA, Francis DA, Clausen J
J Neurol Sci. 2001
PubMed ID: 11239948
Lack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation.
Sullivan TJ, Letterio JJ, van Elsas A, Mamura M, van Amelsfort J, Sharpe S, Metzler B, Chambers CA, Allison JP
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11226283
Identification of an alternatively spliced variant of human CD86 mRNA.
Magistrelli G, Caron G, Gauchat JF, Jeannin P, Bonnefoy JY, Delneste Y
Biochem Biophys Res Commun. 2001
PubMed ID: 11162656
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Association of DRB1*04-DQB1*0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto's thyroiditis in an Italian population.
Petrone A, Giorgi G, Mesturino CA, Capizzi M, Cascino I, Nistico L, Osborn J, Di Mario U, Buzzetti R
Thyroid. 2001
PubMed ID: 11288988
CTLA-4 regulates induction of anergy in vivo.
Greenwald RJ, Boussiotis VA, Lorsbach RB, Abbas AK, Sharpe AH
Immunity. 2001
PubMed ID: 11239447
Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice.
Gozalo-Sanmillan S, McNally JM, Lin MY, Chambers CA, Berg LJ
J Immunol. 2001
PubMed ID: 11145642
Polymorphsims of CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in spondyloarthropathies.
Lee YH, Ji JD, Sohn J, Song GG
Clin Rheumatol. 2001
PubMed ID: 11771526
CTLA-4 gene polymorphism in promoter and exon-1 regions in Chinese patients with systemic lupus erythematosus.
Liu MF, Wang CR, Lin LC, Wu CR
Lupus. 2001
PubMed ID: 11678454
Polymorphisms of the CTLA-4 exon 1 and promoter gene in systemic lupus erythematosus.
Lee YH, Kim YR, Ji JD, Sohn J, Song GG
Lupus. 2001
PubMed ID: 11678447
Cytotoxic T-lymphocyte antigen-4 microsatellite polymorphism is associated with multiple myeloma.
Zheng C, Huang D, Liu L, Björkholm M, Holm G, Yi Q, Sundblad A
Br J Haematol. 2001
PubMed ID: 11167807
Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis.
Ishikawa T, Tamai Y, Zorn AM, Yoshida H, Seldin MF, Nishikawa S, Taketo MM
Development. 2001
PubMed ID: 11092808
CTLA-4 gene polymorphism in Japanese patients with rheumatoid arthritis.
Yanagawa T, Gomi K, Nakao EI, Inada S
J Rheumatol. 2000
PubMed ID: 11128657
CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease.
Kouki T, Sawai Y, Gardine CA, Fisfalen ME, Alegre ML, DeGroot LJ
J Immunol. 2000
PubMed ID: 11086105
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Structure of murine CTLA-4 and its role in modulating T cell responsiveness.
Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG
Science. 2000
PubMed ID: 11052947
Association of autoimmune thyroid disease with microsatellite markers for the thyrotropin receptor gene and CTLA-4 in Japanese patients.
Akamizu T, Sale MM, Rich SS, Hiratani H, Noh JY, Kanamoto N, Saijo M, Miyamoto Y, Saito Y, Nakao K, Bowden DW
Thyroid. 2000
PubMed ID: 11081251
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Porcine CTLA4-Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4+ T cell responses costimulated by pig but not human B7.
Vaughan AN, Malde P, Rogers NJ, Jackson IM, Lechler RI, Dorling A
J Immunol. 2000
PubMed ID: 10975832
Soluble CD86 is a costimulatory molecule for human T lymphocytes.
Jeannin P, Magistrelli G, Aubry JP, Caron G, Gauchat JF, Renno T, Herbault N, Goetsch L, Blaecke A, Dietrich PY, Bonnefoy JY, Delneste Y
Immunity. 2000
PubMed ID: 11021528
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene.
Deng Z, Morse JH, Slager SL, Cuervo N, Moore KJ, Venetos G, Kalachikov S, Cayanis E, Fischer SG, Barst RJ, Hodge SE, Knowles JA
Am J Hum Genet. 2000
PubMed ID: 10903931
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.
Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, Mak TW, Sakaguchi S
J Exp Med. 2000
PubMed ID: 10899917
Complex association analysis of graves disease using a set of polymorphic markers.
Chistyakov DA, Savost'anov KV, Turakulov RI, Petunina NA, Trukhina LV, Kudinova AV, Balabolkin MI, Nosikov VV
Mol Genet Metab. 2000
PubMed ID: 10924276
Cutting edge: a soluble form of CTLA-4 in patients with autoimmune thyroid disease.
Oaks MK, Hallett KM
J Immunol. 2000
PubMed ID: 10799854
Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.
Chikuma S, Murakami M, Tanaka K, Uede T
J Cell Biochem. 2000
PubMed ID: 10842319
A native soluble form of CTLA-4.
Oaks MK, Hallett KM, Penwell RT, Stauber EC, Warren SJ, Tector AJ
Cell Immunol. 2000
PubMed ID: 10831323
A transgenic insertional inner ear mutation on mouse chromosome 1.
Friedman RA, Adir Y, Crenshaw EB, Ryan AF, Rosenfeld MG
Laryngoscope. 2000
PubMed ID: 10763993
Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice.
Haywood ME, Hogarth MB, Slingsby JH, Rose SJ, Allen PJ, Thompson EM, Maibaum MA, Chandler P, Davies KA, Simpson E, Walport MJ, Morley BJ
Arthritis Rheum. 2000
PubMed ID: 10693874
The Nef protein of HIV-1 associates with rafts and primes T cells for activation.
Wang JK, Kiyokawa E, Verdin E, Trono D
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10618429
Cloning and sequencing of dog cDNA encoding the T-cell costimulatory molecule (CTLA-4).
Khatlani TS, Ohno K, Ma Z, Inokuma H, Onishi T
Immunogenetics. 2000
PubMed ID: 10663567
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy.
Kwon ED, Foster BA, Hurwitz AA, Madias C, Allison JP, Greenberg NM, Burg MB
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10611340
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.
Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, Nguyen LT, Ohashi PS, Lacey DL, Fish E, Boyle WJ, Penninger JM
Nature. 1999
PubMed ID: 10580503
Cloning of feline cDNA encoding the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).
Ohno K, Fujiki M, Khatlani TS, Inokuma H, Onishi T
J Vet Med Sci. 1999
PubMed ID: 10593583
A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells.
Magistrelli G, Jeannin P, Herbault N, Benoit De Coignac A, Gauchat JF, Bonnefoy JY, Delneste Y
Eur J Immunol. 1999
PubMed ID: 10556814
Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts.
Mandelbrot DA, Furukawa Y, McAdam AJ, Alexander SI, Libby P, Mitchell RN, Sharpe AH
J Immunol. 1999
PubMed ID: 10490971
Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders.
Ling V, Wu PW, Finnerty HF, Sharpe AH, Gray GS, Collins M
Genomics. 1999
PubMed ID: 10493833
Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis.
Chang TT, Jabs C, Sobel RA, Kuchroo VK, Sharpe AH
J Exp Med. 1999
PubMed ID: 10477557
The role of CTLA-4 in regulating Th2 differentiation.
Oosterwegel MA, Mandelbrot DA, Boyd SD, Lorsbach RB, Jarrett DY, Abbas AK, Sharpe AH
J Immunol. 1999
PubMed ID: 10453003
Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy.
Vaidya B, Imrie H, Perros P, Dickinson J, McCarthy MI, Kendall-Taylor P, Pearce SH
Lancet. 1999
PubMed ID: 10475192
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses.
Chambers CA, Kuhns MS, Allison JP
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10411922
The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus.
Vaidya B, Imrie H, Perros P, Young ET, Kelly WF, Carr D, Large DM, Toft AD, McCarthy MI, Kendall-Taylor P, Pearce SH
Hum Mol Genet. 1999
PubMed ID: 10369864
Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses.
Khattri R, Auger JA, Griffin MD, Sharpe AH, Bluestone JA
J Immunol. 1999
PubMed ID: 10229811
CD28/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family-based association study.
Holopainen P, Arvas M, Sistonen P, Mustalahti K, Collin P, Mäki M, Partanen J
Tissue Antigens. 1999
PubMed ID: 10372542
Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.
Chuang E, Lee KM, Robbins MD, Duerr JM, Alegre ML, Hambor JE, Neveu MJ, Bluestone JA, Thompson CB
J Immunol. 1999
PubMed ID: 9973379
B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).
Mandelbrot DA, McAdam AJ, Sharpe AH
J Exp Med. 1999
PubMed ID: 9892625
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis.
Harbo HF, Celius EG, Vartdal F, Spurkland A
Tissue Antigens. 1999
PubMed ID: 10082437
Physical and genetic linkage of glutaminase (Gls), signal transducer and activator of transcription 1 (Stat1), and xeroderma pigmentosum complementation group G (Xpg) on mouse proximal chromosome 1.
Lévy N, Boettger-Tong H, Dohmae K, Agoulnik AI, Ty TI, Nishimune Y, Bishop CE
Genomics. 1998
PubMed ID: 9828143
A structural explanation for the recognition of tyrosine-based endocytotic signals.
Owen DJ, Evans PR
Science. 1998
PubMed ID: 9812899
Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.
Schneider H, Schwartzberg PL, Rudd CE
Biochem Biophys Res Commun. 1998
PubMed ID: 9813138
Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells.
Chambers CA, Sullivan TJ, Truong T, Allison JP
Eur J Immunol. 1998
PubMed ID: 9808182
Expression and function of CTLA-4 in Th1 and Th2 cells.
Alegre ML, Shiels H, Thompson CB, Gajewski TF
J Immunol. 1998
PubMed ID: 9759851
Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).
Miyatake S, Nakaseko C, Umemori H, Yamamoto T, Saito T
Biochem Biophys Res Commun. 1998
PubMed ID: 9712716
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T, Holtmann H, Lonai P, Wallach D
Immunity. 1998
PubMed ID: 9729047
Immune cell signaling aberrations in human lupus.
Liossis SN, Sfikakis PP, Tsokos GC
Immunol Res. 1998
PubMed ID: 9724847
CTLA-4 gene polymorphism is associated with predisposition to coeliac disease.
Djilali-Saiah I, Schmitz J, Harfouch-Hammoud E, Mougenot JF, Bach JF, Caillat-Zucman S
Gut. 1998
PubMed ID: 10189842
Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice.
Gärdby E, Lane P, Lycke NY
J Immunol. 1998
PubMed ID: 9647206
B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge.
Zheng P, Wu Y, Guo Y, Lee C, Liu Y
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9600957
CTLA-4 is required for the induction of high dose oral tolerance.
Samoilova EB, Horton JL, Zhang H, Khoury SJ, Weiner HL, Chen Y
Int Immunol. 1998
PubMed ID: 9620605
Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells.
Bachmann MF, Waterhouse P, Speiser DE, McKall-Faienza K, Mak TW, Ohashi PS
J Immunol. 1998
PubMed ID: 9551960
Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells.
Chambers CA, Sullivan TJ, Allison JP
Immunity. 1997
PubMed ID: 9430233
Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease.
Donner H, Braun J, Seidl C, Rau H, Finke R, Ventz M, Walfish PG, Usadel KH, Badenhoop K
J Clin Endocrinol Metab. 1997
PubMed ID: 9398726
Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse.
Yang Z, Hanlon DW, Marszalek JR, Goldstein LS
Genomics. 1997
PubMed ID: 9339368
Thymocyte development is normal in CTLA-4-deficient mice.
Chambers CA, Cado D, Truong T, Allison JP
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9256476
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein.
Zhang Y, Allison JP
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9256472
Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice.
Waterhouse P, Bachmann MF, Penninger JM, Ohashi PS, Mak TW
Eur J Immunol. 1997
PubMed ID: 9295023
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer.
Kwon ED, Hurwitz AA, Foster BA, Madias C, Feldhaus AL, Greenberg NM, Burg MB, Allison JP
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9223321
Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28.
Metzler WJ, Bajorath J, Fenderson W, Shaw SY, Constantine KL, Naemura J, Leytze G, Peach RJ, Lavoie TB, Mueller L, Linsley PS
Nat Struct Biol. 1997
PubMed ID: 9228944
Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.
Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB
J Immunol. 1997
PubMed ID: 9200449
CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.
Tivol EA, Boyd SD, McKeon S, Borriello F, Nickerson P, Strom TB, Sharpe AH
J Immunol. 1997
PubMed ID: 9164923
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.
Shiratori T, Miyatake S, Ohno H, Nakaseko C, Isono K, Bonifacino JS, Saito T
Immunity. 1997
PubMed ID: 9175836
Mapping of unconventional myosins in mouse and human.
Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA
Genomics. 1996
PubMed ID: 8884266
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.
Marengère LE, Waterhouse P, Duncan GS, Mittrücker HW, Feng GS, Mak TW
Science. 1996
PubMed ID: 8638161
A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.
Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J
J Biol Chem. 1996
PubMed ID: 8626800
Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis.
Truneh A, Reddy M, Ryan P, Lyn SD, Eichman C, Couez D, Hurle MR, Sekaly RP, Olive D, Sweet R
Mol Immunol. 1996
PubMed ID: 8649453
Mouse chromosomal location of four Na/H exchanger isoform genes.
Pathak BG, Shull GE, Jenkins NA, Copeland NG
Genomics. 1996
PubMed ID: 8824815
Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.
Spur NK, Bashir R, Bushby K, Cox A, Cox S, Hilde Brandt F, Hill N, Kao FT, Krols L, Marzella R, Miller N, Nothwang HG, Rocchi M, Sarfarazi M, Stratakis CA, Wallgren-Petterson C, Naylor S
Cytogenet Cell Genet. 1996
PubMed ID: 8751373
Nucleotide sequence of the ACI rat CTLA-4 molecule.
Oaks MK, Penwell RT, Tector AJ
Immunogenetics. 1996
PubMed ID: 8550107
Identification and chromosomal mapping of the mouse inositol polyphosphate 1-phosphatase gene.
Okabe I, Nussbaum RL
Genomics. 1995
PubMed ID: 8586440
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4.
Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, Thompson CB, Griesser H, Mak TW
Science. 1995
PubMed ID: 7481803
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.
Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH
Immunity. 1995
PubMed ID: 7584144
Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail.
Leung HT, Bradshaw J, Cleaveland JS, Linsley PS
J Biol Chem. 1995
PubMed ID: 7559643
Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28.
Peach RJ, Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley PS
J Biol Chem. 1995
PubMed ID: 7545666
Distribution of the mammalian Stat gene family in mouse chromosomes.
Copeland NG, Gilbert DJ, Schindler C, Zhong Z, Wen Z, Darnell JE, Mui AL, Miyajima A, Quelle FW, Ihle JN
Genomics. 1995
PubMed ID: 8530075
Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4.
Fargeas CA, Truneh A, Reddy M, Hurle M, Sweet R, Sékaly RP
J Exp Med. 1995
PubMed ID: 7544393
Efficient high-resolution genetic mapping of mouse interspersed repetitive sequence PCR products, toward integrated genetic and physical mapping of the mouse genome.
McCarthy L, Hunter K, Schalkwyk L, Riba L, Anson S, Mott R, Newell W, Bruley C, Bar I, Ramu E
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7777502
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.
Schneider H, Prasad KV, Shoelson SE, Rudd CE
J Exp Med. 1995
PubMed ID: 7807015
Cloning and sequencing of the rabbit gene encoding T-cell costimulatory molecules.
Isono T, Seto A
Immunogenetics. 1995
PubMed ID: 7642234
The murine dilute suppressor gene encodes a cell autonomous suppressor.
Moore KJ, Swing DA, Copeland NG, Jenkins NA
Genetics. 1994
PubMed ID: 7828830
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.
Yamamoto K, Quelle FW, Thierfelder WE, Kreider BL, Gilbert DJ, Jenkins NA, Copeland NG, Silvennoinen O, Ihle JN
Mol Cell Biol. 1994
PubMed ID: 8007943
Soluble CTLA-4 can suppress autoantibody production and elicit long term unresponsiveness in a novel transgenic model.
Milich DR, Linsley PS, Hughes JL, Jones JE
J Immunol. 1994
PubMed ID: 7515930
In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice.
Blazar BR, Taylor PA, Linsley PS, Vallera DA
Blood. 1994
PubMed ID: 7515723
Genetic mapping of 40 cDNA clones on the mouse genome by PCR.
Ko MS, Wang X, Horton JH, Hagen MD, Takahashi N, Maezaki Y, Nadeau JH
Mamm Genome. 1994
PubMed ID: 8043949
Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11.
Kou K, James PL, Clemmons DR, Copeland NG, Gilbert DJ, Jenkins NA, Rotwein P
Genomics. 1994
PubMed ID: 7525452
Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule.
Chen C, Gault A, Shen L, Nabavi N
J Immunol. 1994
PubMed ID: 7513726
Maps from two interspecific backcross DNA panels available as a community genetic mapping resource.
Rowe LB, Nadeau JH, Turner R, Frankel WN, Letts VA, Eppig JT, Ko MS, Thurston SJ, Birkenmeier EH
Mamm Genome. 1994
PubMed ID: 8075499
Organization, expression, and chromosomal location of the mouse insulin-like growth factor binding protein 5 gene.
Kou K, Jenkins NA, Gilbert DJ, Copeland NG, Rotwein P
Genomics. 1994
PubMed ID: 7518410
Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.
Freeman GJ, Borriello F, Hodes RJ, Reiser H, Gribben JG, Ng JW, Kim J, Goldberg JM, Hathcock K, Laszlo G
J Exp Med. 1993
PubMed ID: 7504059
B70 antigen is a second ligand for CTLA-4 and CD28.
Azuma M, Ito D, Yagita H, Okumura K, Phillips JH, Lanier LL, Somoza C
Nature. 1993
PubMed ID: 7694153
Murine chromosomal location of four class III POU transcription factors.
Avraham KB, Cho BC, Gilbert D, Fujii H, Okamoto K, Shimazaki T, Ito T, Shoji H, Wakamatsu Y, Kondoh H
Genomics. 1993
PubMed ID: 8276397
Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1.
Lane P, Gerhard W, Hubele S, Lanzavecchia A, McConnell F
Immunology. 1993
PubMed ID: 8244464
Chromosomal localization of mouse bullous pemphigoid antigens. BPAG1 and BPAG2: identification of a new region of homology between mouse and human chromosomes.
Copeland NG, Gilbert DJ, Li K, Sawamura D, Giudice GJ, Chu ML, Jenkins NA, Uitto J
Genomics. 1993
PubMed ID: 8432531
CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.
Freeman GJ, Lombard DB, Gimmi CD, Brod SA, Lee K, Laning JC, Hafler DA, Dorf ME, Gray GS, Reiser H
J Immunol. 1992
PubMed ID: 1281186
The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis, and chromosomal localization.
Cole TJ, Copeland NG, Gilbert DJ, Jenkins NA, Schütz G, Ruppert S
Genomics. 1992
PubMed ID: 1387109
Quantitative polymerase chain reaction analysis of cytotoxic cell proteinase gene transcripts in T cells. Pattern of expression is dependent on the nature of the stimulus.
Prendergast JA, Helgason CD, Bleackley RC
J Biol Chem. 1992
PubMed ID: 1544892
A set of anonymous DNA clones as markers for mouse gene mapping.
Le Roy H, Simon-Chazottes D, Montagutelli X, Guénet JL
Mamm Genome. 1992
PubMed ID: 1351769
Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16.
Colombo MP, Martinotti A, Howard TA, Schneider C, D'Eustachio P, Seldin MF
Mamm Genome. 1992
PubMed ID: 1347472
Pax: a murine multigene family of paired box-containing genes.
Walther C, Guenet JL, Simon D, Deutsch U, Jostes B, Goulding MD, Plachov D, Balling R, Gruss P
Genomics. 1991
PubMed ID: 1685142
CTLA-4 is a second receptor for the B cell activation antigen B7.
Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA
J Exp Med. 1991
PubMed ID: 1714933
Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping.
Tominaga S, Jenkins NA, Gilbert DJ, Copeland NG, Tetsuka T
Biochim Biophys Acta. 1991
PubMed ID: 1832015
CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.
Harper K, Balzano C, Rouvier E, Mattéi MG, Luciani MF, Golstein P
J Immunol. 1991
PubMed ID: 1713603
Chromosomal location of murine and human IL-1 receptor genes.
Copeland NG, Silan CM, Kingsley DM, Jenkins NA, Cannizzaro LA, Croce CM, Huebner K, Sims JE
Genomics. 1991
PubMed ID: 1672292
Cd28 and Ctla-4, two related members of the Ig supergene family, are tightly linked on proximal mouse chromosome 1.
Howard TA, Rochelle JM, Seldin MF
Immunogenetics. 1991
PubMed ID: 1671668
Myogenin is in an evolutionarily conserved linkage group on human chromosome 1q31-q41 and unlinked to other mapped muscle regulatory factor genes.
Olson E, Edmondson D, Wright WE, Lin VK, Guenet JL, Simon-Chazottes D, Thompson LH, Stallings RL, Schroeder WT, Duvic M
Genomics. 1990
PubMed ID: 1962752
Molecular analysis of the murine C4b-binding protein gene. Chromosome assignment and partial gene organization.
Barnum SR, Kristensen T, Chaplin DD, Seldin MF, Tack BF
Biochemistry. 1989
PubMed ID: 2574991
A glutaminase (gis) gene maps to mouse chromosome 1, rat chromosome 9, and human chromosome 2.
Mock B, Kozak C, Seldin MF, Ruff N, D'Hoostelaere L, Szpirer C, Levan G, Seuanez H, O'Brien S, Banner C
Genomics. 1989
PubMed ID: 2571577
Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains.
Dariavach P, Mattéi MG, Golstein P, Lefranc MP
Eur J Immunol. 1988
PubMed ID: 3220103
A new member of the immunoglobulin superfamily--CTLA-4.
Brunet JF, Denizot F, Luciani MF, Roux-Dosseto M, Suzan M, Mattei MG, Golstein P
Nature. 1987
PubMed ID: 3496540

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	1493	12477	63835
EnsEMBL Gene(s)	ENSG00000163599	ENSMUSG00000026011	ENSRNOG00000010336
Unigene	Hs.247824	Mm.390	Rn.10259
Homologene	CTLA4	Ctla4	Ctla4
OMIM	123890	N/A	N/A
GeneCards	CTLA4	N/A	N/A
Beta Cell Genomics	DT.40126443 DT.91756479	DT.40181215 DT.99854682	N/A
Reactome	P16410	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	1493	12477	63835

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
CTLA4	AP2M1	HPRD, MIPS, BioGRID	empirical	9200449 9256472 11583591
CTLA4	CTLA4	HPRD	empirical	11279501
CTLA4	FYN	HPRD	empirical	9712716 9973379
CTLA4	JAK2	HPRD	empirical	10842319
CTLA4	LCK	HPRD	empirical	9712716 9973379
CTLA4	LYN	HPRD	empirical	9712716
CTLA4	PIK3R1	HPRD	empirical	7807015
CTLA4	PPP2R5A	HPRD	empirical	11994459
CTLA4	PTPN11	HPRD	empirical	8638161
CTLA4	STAT5A	HPRD	empirical	16476059
CTLA4	STAT5B	HPRD	empirical	16476059
CTLA4	TXK	HPRD	empirical	9813138
CTLA4	AP1M1	HPRD	empirical	9812899 11583591
CTLA4	CD80	HPRD, IntAct	empirical	7545666 11279502 21982860
CTLA4	CD86	HPRD, IntAct	empirical	11279501 11021528 12606712 12071705 12582153 7513726 7694153 11162656 21982860